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Enhanced therapeutic effects on the multi-drug resistant human leukemia cells in vitro and xenograft in mice using the stealthy liposomal vincristine plus quinacrine
Liang, Gong-Wen1,2; Lu, Wan-Liang1,2; Wu, Jin-Wei1,2; Zhao, Ji-Hui1,2; Hong, Hai-Yan3; Long, Chuan3; Li, Ting1,2; Zhang, Yu-Teng1,2; Zhang, Hua1,2; Wang, Jian-Cheng1,2; Zhang, Xuan1,2; Zhang, Qiang1,2
关键词Anti-resistant Tumor Effects Caspases Leukemia Stealthy Liposomal Vincristine Plus Quinacrine
刊名FUNDAMENTAL & CLINICAL PHARMACOLOGY
2008-08-01
DOI10.1111/j.1472-8206.2008.00613.x
22期:4页:429-437
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pharmacology & Pharmacy
研究领域[WOS]Pharmacology & Pharmacy
关键词[WOS]PEGYLATED LIPOSOMES ; ANTITUMOR-ACTIVITY ; BEARING MICE ; LUNG-CANCER ; APOPTOSIS ; PATHWAYS ; LYMPHOMA ; GROWTH ; GENE ; PHARMACOKINETICS
英文摘要

The multi-drug resistance (MDR) could be caused by the over-expression of adenosine triphosphate binding cassette transporters such as p-glycoprotein, thereby resulting in the efflux of anti-cancer drugs from the cells. An anti-resistant stealthy liposomal vincristine plus quinacrine was defined in this study. Human chronic myelogenous leukemia K562 and MDR K562 cells were included for comparisons. Anti-tumor activity studies were performed on female BALB/c nude mice with MDR K562 cell xenografts. Results showed that quinacrine was effective in reversing the resistance in the MDR K562 cells, and enhanced the anti-tumor effect of vincristine in K562 cells. The caspase-9 and -3 activities in the MDR K562 and K562 cells were increased with the dose rise of quinacrine. In the MDR K562 cell xenografts in mice, the anti-resistant tumor effect of the stealthy liposomal vincristine plus quinacrine was evidently observed. The enhanced anti-tumor effects of vincristine by quinacrine in the resistant/non-resistant K562 cells could be because of the direct injury and the potentiating apoptotic effect of vincristine via activating the initiator caspase-9 and subsequently the effector caspase-3, and the long circulatory effect of stealthy liposomes. The stealthy liposomal encapsulation of vincristine plus quinacrine could be a potential therapeutic approach for resistant human leukemia.

语种英语
WOS记录号WOS:000257712800009
Citation statistics
Cited Times:25[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53225
Collection北京大学药学院
作者单位1.Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, Beijing 100083, Peoples R China
3.Peking Univ, Ctr Human Dis Genom, Beijing 100083, Peoples R China
Recommended Citation
GB/T 7714
Liang, Gong-Wen,Lu, Wan-Liang,Wu, Jin-Wei,et al. Enhanced therapeutic effects on the multi-drug resistant human leukemia cells in vitro and xenograft in mice using the stealthy liposomal vincristine plus quinacrine[J]. FUNDAMENTAL & CLINICAL PHARMACOLOGY,2008,22(4):429-437.
APA Liang, Gong-Wen.,Lu, Wan-Liang.,Wu, Jin-Wei.,Zhao, Ji-Hui.,Hong, Hai-Yan.,...&Zhang, Qiang.(2008).Enhanced therapeutic effects on the multi-drug resistant human leukemia cells in vitro and xenograft in mice using the stealthy liposomal vincristine plus quinacrine.FUNDAMENTAL & CLINICAL PHARMACOLOGY,22(4),429-437.
MLA Liang, Gong-Wen,et al."Enhanced therapeutic effects on the multi-drug resistant human leukemia cells in vitro and xenograft in mice using the stealthy liposomal vincristine plus quinacrine".FUNDAMENTAL & CLINICAL PHARMACOLOGY 22.4(2008):429-437.
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