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Molecular recognition in a reconstituted tumor cell membrane
Hu, X1; Wang, SH1; Zhang, YF1; Lu, XD1; Hou, XP1; Ottova, A1; Tien, HT1
关键词Molecular Recognition Immunoliposomes Sb-blm Electrical Properties Anticancer Drugs Adriamycin Planar Lipid Bilayer Bilayer Lipid Membrane
刊名JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
2001-09-01
26期:2页:219-224
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Analytical ; Pharmacology & Pharmacy
研究领域[WOS]Chemistry ; Pharmacology & Pharmacy
关键词[WOS]IMMUNOLIPOSOMES ; LIPOSOMES
英文摘要

The design of an immunoliposome system for molecular recognition using reconstituted, hydrogel-supported bilayer lipid membranes (sb-BLMs) is described. By monitoring the electrical properties. two kinds of recognition are feasible: (i) the human bladder tumor cells, Ej and its antibody BDI-1, the lifetime of the reconstituted membrane is 42 min, and (ii) the human rectum tumor cells, LOVO, the life of the reconstructed membrane is more than 40 min, the same as conventional BLM. Further, the anticancer drug, Adriamycin (Anticancer Res., 20 (2000) 1391), was shown to be effective in such reconstituted systems, the life of which is less than 5 min. In these experiments, the active ingredients of the Ej and LOVO cells were determined on reconstituted sb-BLMs. The key point is that the component part being recognized on the BLM must be kept in its native state. (C) 2001 Elsevier Science B.V. All rights reserved.

语种英语
WOS记录号WOS:000170562600006
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53227
专题北京大学药学院
北京大学药学院_药剂学系
作者单位1.Beijing Univ, Sch Pharmaceut Sci, Dept Phys Pharm, Beijing 100083, Peoples R China
2.Michigan State Univ, Dept Physiol, E Lansing, MI 48824 USA
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GB/T 7714
Hu, X,Wang, SH,Zhang, YF,et al. Molecular recognition in a reconstituted tumor cell membrane[J]. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,2001,26(2):219-224.
APA Hu, X.,Wang, SH.,Zhang, YF.,Lu, XD.,Hou, XP.,...&Tien, HT.(2001).Molecular recognition in a reconstituted tumor cell membrane.JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,26(2),219-224.
MLA Hu, X,et al."Molecular recognition in a reconstituted tumor cell membrane".JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 26.2(2001):219-224.
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