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学科主题: 药学
题名:
Evidence of gastro-intestinal system as an active and toxic target of sasanqua saponins extract
作者: Shen, Jia1; Cao, Cunai1; Su, Hui1; Yang, Xiuwei2; Wei, Zuohan1; Du, Lijun1
关键词: sasanqua saponins extract ; toxicity ; gastro-intestinal system
刊名: EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY
发表日期: 2008-06-01
DOI: 10.1016/j.etp.2007.11.016
卷: 60, 期:1, 页:43-49
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pathology ; Toxicology
研究领域[WOS]: Pathology ; Toxicology
关键词[WOS]: L RYOKUCHA-SAPONIN ; TEA-LEAF SAPONIN ; CAMELLIA-SINENSIS ; ROOT EXTRACT ; BIOACTIVE SAPONINS ; SEED SAPONINS ; PLANT ; RATS ; ASSAMSAPONINS ; GLYCOSIDES
英文摘要:

Sasanqua saponins extract (SSE) was prepared from the remainder of seeds of Camellia sasanqua after oil extract using ethanol as solvent. We have now evaluated the acute and subchronic toxicity of SSE by oral route in mice. A single oral administration of SSE (125-2000mg/kg) produced a dose-dependent increase in adverse effects and the mortality rate of mice; the LD50 of acute oral dose was determined as 1143.7mg/kg for both sexes, with 95% confidence limit of 608.2-2150.6mg/kg. In the subchronic toxicological study, SSE was administered orally at daily doses of 100, 200 and 400 mg/kg for 6 weeks. Mice of the 100 and 200 mg/kg SSE groups did not show obvious changes in the body weight, organ index and biochemical parameters, with the exception of a slight rise in serum GOT level and a decrease in triglyceride level. But mice of the 400 mg/kg SSE group died during the treated period and showed severe gastro-intestinal tract distension and submucosal changes in the small intestine. We studied further the effects of SSE on the gastric and intestinal tract function at the doses of 100 and 200 mg/kg, and found that, in mice after oral or intraperitoneal administration or SSE, the gastric empty and the small intestinal motility significantly decreased. The excretion time of feces was significantly prolonged by the oral SSE treatment. These results indicate that SSE is a kind of extract of a narrow active window and the its active and toxic target could be gastro-intestinal system. (c) 2008 Elsevier GmbH. All rights reserved.

语种: 英语
WOS记录号: WOS:000257260200005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53229
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, Sch Pharm, Beijing 100871, Peoples R China
2.Tsinghua Univ, Lab Pharmaceut Sci, Dept Biol Sci & Biotechnol, Beijing 100084, Peoples R China

Recommended Citation:
Shen, Jia,Cao, Cunai,Su, Hui,et al. Evidence of gastro-intestinal system as an active and toxic target of sasanqua saponins extract[J]. EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY,2008,60(1):43-49.
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