北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 基础医学院  > 神经生物学系  > 期刊论文
学科主题: 基础医学
题名:
Triptolide, a Chinese herbal extract, protects dopaminergic neurons from inflammation-mediated damage through inhibition of microglial activation
作者: Li, FQ; Lu, XZ; Liang, XB; Zhou, HF; Xue, B; Liu, XY; Niu, DB; Han, JS; Wang, XM
关键词: triptolide ; Tripterygium wilfordii Hook F ; inflammation ; microglia ; Parkinson&prime ; s disease ; neurodegeneration
刊名: JOURNAL OF NEUROIMMUNOLOGY
发表日期: 2004-03-01
DOI: 10.1016/j.jneuroim.2003.10.054
卷: 148, 期:1-2, 页:24-31
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Immunology ; Neurosciences
研究领域[WOS]: Immunology ; Neurosciences & Neurology
关键词[WOS]: NF-KAPPA-B ; NECROSIS-FACTOR-ALPHA ; NITRIC-OXIDE SYNTHASE ; WILFORDII HOOK-F ; TRIPTERYGIUM-WILFORDII ; PARKINSONS-DISEASE ; NEURODEGENERATIVE DISORDERS ; SUBSTANTIA-NIGRA ; GLIAL-CELLS ; TNF-ALPHA
英文摘要:

Mounting lines of evidence have suggested that brain inflammation participates in the pathogenesis of Parkinson′s disease. Triptolide is one of the major active components of Chinese herb Tripterygium wilfordii Hook F, which possesses potent anti-inflammatory and immunosuppressive properties. We found that triptolide concentration-dependently attenuated the lipopolysaccharide (LPS)-induced decrease in [H-3]dopamine uptake and loss of tyrosine hydroxylase-immunoreactive neurons in primary mesencephalic neuron/glia mixed culture. Triptolide also blocked LPS-induced activation of microglia and excessive production of TNFalpha and NO. Our data suggests that triptolide may protect dopaminergic neurons from LPS-induced injury and its efficiency in inhibiting microglia activation may underlie the mechanism. (C) 2003 Elsevier B.V. All rights reserved.

语种: 英语
WOS记录号: WOS:000189218600003
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53231
Appears in Collections:基础医学院_神经生物学系_期刊论文

Files in This Item: Download All
File Name/ File Size Content Type Version Access License
Triptolide, a Chinese herbal extract, protects dopaminergic neurons from inflammation-mediated damage through inhibition of microglial activation.pdf(587KB)期刊论文出版稿限制开放View Download

作者单位: Peking Univ, Neurosci Res Inst, Beijing 100083, Peoples R China

Recommended Citation:
Li, FQ,Lu, XZ,Liang, XB,et al. Triptolide, a Chinese herbal extract, protects dopaminergic neurons from inflammation-mediated damage through inhibition of microglial activation[J]. JOURNAL OF NEUROIMMUNOLOGY,2004,148(1-2):24-31.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Li, FQ]'s Articles
[Lu, XZ]'s Articles
[Liang, XB]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Li, FQ]‘s Articles
[Lu, XZ]‘s Articles
[Liang, XB]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
文件名:  !E inese herbal extract, protects dopaminergic neurons from inflammation-mediated damage through inhibition of microglial activation.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace