北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第一临床医学院  > 心血管内科  > 期刊论文
学科主题: 临床医学
题名:
beta(2) adrenergic receptor gene Arg16Gly polymorphism is associated with therapeutic efficacy of benazepril on essential hypertension in Chinese
作者: Huang, G1; Xing, HX1; Hao, K1; Peng, SJ1; Wu, D1; Guang, WW1; Huang, AQ1; Hong, XM1; Wang, YP1; Feng, Y1; Zhang, Y1; Li, JP1; Chen, CZ1; Wang, GY1; Huo, Y1; Chen, DF1; Hou, YT1; Wang, XB1; Xu, X1; Niu, TH1; Xu, XP1
关键词: ADRB2 gene ; gene polymorphism ; benazepril ; blood pressure ; pharmacogenetics
刊名: CLINICAL AND EXPERIMENTAL HYPERTENSION
发表日期: 2004-08-01
DOI: 10.1081/CEH-200031839
卷: 26, 期:6, 页:581-592
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy ; Peripheral Vascular Disease
研究领域[WOS]: Pharmacology & Pharmacy ; Cardiovascular System & Cardiology
关键词[WOS]: CONVERTING-ENZYME-INHIBITOR ; BETA-2-ADRENERGIC RECEPTOR ; BLOOD-PRESSURE ; UNIFIED APPROACH ; DRUG-THERAPY ; POPULATION ; VASODILATION ; HEALTH ; GENOME ; ASTHMA
英文摘要:

Background: There is considerable variability in individual response to antihypertensive agents. The reason for this is not known, but may be related to individual genetic variability. This study examined whether the therapeutic efficacy of benazepril on essential hypertension is modified by beta(2) adrenergic receptor gene (ADRB2) Arg16Gly (R16G) polymorphism. Methods and Results: We conducted a family-based study of 321 and 610 hypertensive subjects from Yuexi and Huoqiu Counties of Anhui, China, respectively. Both systolic and diastolic blood pressures (SBP and DBP) before and after a 15-day benazepril treatment were measured. ADRB2 R16G genotypes were determined for all subjects. ADRB2 G16 allele frequency was found to be 41.0% and. 47.4% in Huoqiu and Yuexi, respectively. In Yuexi family-based association test (FBAT) revealed that the G16 allele was associated with a greater DBP decrease in response to a 15-day benazepril treatment (Z = 2.12, P = 0.03), and the data were consistent with a dominant inheritance model. A similar trend was observed in Huoqiu Chinese, but the magnitudes of effects were smaller and did not reach statistical significance. The FBAT results were further confirmed by using a generalized estimating equation model. Conclusion: Our family-based study provided the first evidence that ADRB2 R16G polymorphism may play an important role in DBP response to benazepril treatment, although the magnitude of the effect appears to be modified by other risk factors such as plasma lipid and glucose profiles.

语种: 英语
WOS记录号: WOS:000224975200012
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53235
Appears in Collections:北京大学第一临床医学院_心血管内科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Anhui Med Univ, Inst Biomed, Hefei, Peoples R China
2.Boston Univ, Sch Med, Dept Pediat, Boston, MA 02118 USA
3.Boston Med Ctr, Boston, MA USA
4.Harvard Univ, Sch Publ Hlth, Program Populat Genet, Boston, MA 02115 USA
5.Univ Sci & Technol China, Sch Life Sci, Hefei 230026, Peoples R China
6.Peking Univ, Sch Med, Dept Genet & Cell Biol, Ctr Ecogenet & Reprod Hlth, Beijing, Peoples R China
7.Peking Univ, Affiliated Hosp 1, Dept Cardiovasc Dis, Beijing 100871, Peoples R China
8.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 200031, Peoples R China
9.Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Med,Div Prevent Med, Boston, MA 02115 USA

Recommended Citation:
Huang, G,Xing, HX,Hao, K,et al. beta(2) adrenergic receptor gene Arg16Gly polymorphism is associated with therapeutic efficacy of benazepril on essential hypertension in Chinese[J]. CLINICAL AND EXPERIMENTAL HYPERTENSION,2004,26(6):581-592.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Huang, G]'s Articles
[Xing, HX]'s Articles
[Hao, K]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Huang, G]‘s Articles
[Xing, HX]‘s Articles
[Hao, K]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace