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beta(2) adrenergic receptor gene Arg16Gly polymorphism is associated with therapeutic efficacy of benazepril on essential hypertension in Chinese
Huang, G1; Xing, HX1; Hao, K1; Peng, SJ1; Wu, D1; Guang, WW1; Huang, AQ1; Hong, XM1; Wang, YP1; Feng, Y1; Zhang, Y1; Li, JP1; Chen, CZ1; Wang, GY1; Huo, Y1; Chen, DF1; Hou, YT1; Wang, XB1; Xu, X1; Niu, TH1; Xu, XP1
关键词Adrb2 Gene Gene Polymorphism Benazepril Blood Pressure Pharmacogenetics
刊名CLINICAL AND EXPERIMENTAL HYPERTENSION
2004-08-01
DOI10.1081/CEH-200031839
26期:6页:581-592
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pharmacology & Pharmacy ; Peripheral Vascular Disease
研究领域[WOS]Pharmacology & Pharmacy ; Cardiovascular System & Cardiology
关键词[WOS]CONVERTING-ENZYME-INHIBITOR ; BETA-2-ADRENERGIC RECEPTOR ; BLOOD-PRESSURE ; UNIFIED APPROACH ; DRUG-THERAPY ; POPULATION ; VASODILATION ; HEALTH ; GENOME ; ASTHMA
英文摘要

Background: There is considerable variability in individual response to antihypertensive agents. The reason for this is not known, but may be related to individual genetic variability. This study examined whether the therapeutic efficacy of benazepril on essential hypertension is modified by beta(2) adrenergic receptor gene (ADRB2) Arg16Gly (R16G) polymorphism. Methods and Results: We conducted a family-based study of 321 and 610 hypertensive subjects from Yuexi and Huoqiu Counties of Anhui, China, respectively. Both systolic and diastolic blood pressures (SBP and DBP) before and after a 15-day benazepril treatment were measured. ADRB2 R16G genotypes were determined for all subjects. ADRB2 G16 allele frequency was found to be 41.0% and. 47.4% in Huoqiu and Yuexi, respectively. In Yuexi family-based association test (FBAT) revealed that the G16 allele was associated with a greater DBP decrease in response to a 15-day benazepril treatment (Z = 2.12, P = 0.03), and the data were consistent with a dominant inheritance model. A similar trend was observed in Huoqiu Chinese, but the magnitudes of effects were smaller and did not reach statistical significance. The FBAT results were further confirmed by using a generalized estimating equation model. Conclusion: Our family-based study provided the first evidence that ADRB2 R16G polymorphism may play an important role in DBP response to benazepril treatment, although the magnitude of the effect appears to be modified by other risk factors such as plasma lipid and glucose profiles.

语种英语
WOS记录号WOS:000224975200012
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53235
专题北京大学第一临床医学院_心血管内科
作者单位1.Anhui Med Univ, Inst Biomed, Hefei, Peoples R China
2.Boston Univ, Sch Med, Dept Pediat, Boston, MA 02118 USA
3.Boston Med Ctr, Boston, MA USA
4.Harvard Univ, Sch Publ Hlth, Program Populat Genet, Boston, MA 02115 USA
5.Univ Sci & Technol China, Sch Life Sci, Hefei 230026, Peoples R China
6.Peking Univ, Sch Med, Dept Genet & Cell Biol, Ctr Ecogenet & Reprod Hlth, Beijing, Peoples R China
7.Peking Univ, Affiliated Hosp 1, Dept Cardiovasc Dis, Beijing 100871, Peoples R China
8.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 200031, Peoples R China
9.Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Med,Div Prevent Med, Boston, MA 02115 USA
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Huang, G,Xing, HX,Hao, K,et al. beta(2) adrenergic receptor gene Arg16Gly polymorphism is associated with therapeutic efficacy of benazepril on essential hypertension in Chinese[J]. CLINICAL AND EXPERIMENTAL HYPERTENSION,2004,26(6):581-592.
APA Huang, G.,Xing, HX.,Hao, K.,Peng, SJ.,Wu, D.,...&Xu, XP.(2004).beta(2) adrenergic receptor gene Arg16Gly polymorphism is associated with therapeutic efficacy of benazepril on essential hypertension in Chinese.CLINICAL AND EXPERIMENTAL HYPERTENSION,26(6),581-592.
MLA Huang, G,et al."beta(2) adrenergic receptor gene Arg16Gly polymorphism is associated with therapeutic efficacy of benazepril on essential hypertension in Chinese".CLINICAL AND EXPERIMENTAL HYPERTENSION 26.6(2004):581-592.
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