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学科主题基础医学
Lidamycin regulates p53 expression by repressing Oct4 transcription
Zhen, Hong-Ying1; Zhou, Juan2; Wu, Hou-Nan3; Yao, Cheng2; Zhang, Ting1; Wu, Tong1; Quan, Cheng-Shi4; Li, Yu-Lin4
关键词Lidamycin Oct4 P53 Transcriptional Activation
刊名BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
2014-05-02
DOI10.1016/j.bbrc.2014.03.082
447期:2页:224-230
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Biophysics
资助者National Science and Technology Major Project Focusing on Drug Innovation from the Ministry of Science and Technology of China ; Beijing Natural Science Foundation ; National Science and Technology Major Project Focusing on Drug Innovation from the Ministry of Science and Technology of China ; Beijing Natural Science Foundation
研究领域[WOS]Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]EMBRYONIC STEM-CELLS ; DNA-DAMAGE ; GENE-EXPRESSION ; FUSION PROTEIN ; HUMAN TUMORS ; DIFFERENTIATION ; DEDIFFERENTIATION ; ADENOCARCINOMA ; RECEPTOR ; POTENT
英文摘要

Antitumor antibiotic lidamycin (LDM) is widely used in the treatment of a variety of cancers. Here we demonstrated that LDM up-regulates the expression of the tumor suppressor p53 gene by repressing Oct4 transcription. We showed that low dose LDM-induced increase of p53 expression and decrease of Oct4 expression in P19 and HCT116-p53(+/+) cells. Knockdown of Oct4 expression by siRNA led to activation of p53 in both cell lines, whereas ectopical expression of Oct4 significantly inhibited p53 expression in P19 cells. LDM-induced p53 activation was blocked by ectopical expression of Oct4. (C) 2014 Elsevier Inc. All rights reserved.

语种英语
所属项目编号2009ZX0930-010 ; 2009ZX09102-240 ; 7122098
资助者National Science and Technology Major Project Focusing on Drug Innovation from the Ministry of Science and Technology of China ; Beijing Natural Science Foundation ; National Science and Technology Major Project Focusing on Drug Innovation from the Ministry of Science and Technology of China ; Beijing Natural Science Foundation
WOS记录号WOS:000336510900002
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53236
专题基础医学院_细胞生物学系
作者单位1.Jinlin Univ, Hosp 1, Dept Oncol, Changchun, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, Dept Cell Biol, Beijing 100191, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Med Anal Ctr, Beijing 100191, Peoples R China
4.Jilin Univ, Bethune Med Coll, Minist Educ, Key Lab Pathobiol, Changchun 310021, Jilin, Peoples R China
推荐引用方式
GB/T 7714
Zhen, Hong-Ying,Zhou, Juan,Wu, Hou-Nan,et al. Lidamycin regulates p53 expression by repressing Oct4 transcription[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2014,447(2):224-230.
APA Zhen, Hong-Ying.,Zhou, Juan.,Wu, Hou-Nan.,Yao, Cheng.,Zhang, Ting.,...&Li, Yu-Lin.(2014).Lidamycin regulates p53 expression by repressing Oct4 transcription.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,447(2),224-230.
MLA Zhen, Hong-Ying,et al."Lidamycin regulates p53 expression by repressing Oct4 transcription".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 447.2(2014):224-230.
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