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学科主题: 基础医学
题名:
Lidamycin regulates p53 expression by repressing Oct4 transcription
作者: Zhen, Hong-Ying1; Zhou, Juan2; Wu, Hou-Nan3; Yao, Cheng2; Zhang, Ting1; Wu, Tong1; Quan, Cheng-Shi4; Li, Yu-Lin4
关键词: Lidamycin ; Oct4 ; p53 ; Transcriptional activation
刊名: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
发表日期: 2014-05-02
DOI: 10.1016/j.bbrc.2014.03.082
卷: 447, 期:2, 页:224-230
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]: Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]: EMBRYONIC STEM-CELLS ; DNA-DAMAGE ; GENE-EXPRESSION ; FUSION PROTEIN ; HUMAN TUMORS ; DIFFERENTIATION ; DEDIFFERENTIATION ; ADENOCARCINOMA ; RECEPTOR ; POTENT
英文摘要:

Antitumor antibiotic lidamycin (LDM) is widely used in the treatment of a variety of cancers. Here we demonstrated that LDM up-regulates the expression of the tumor suppressor p53 gene by repressing Oct4 transcription. We showed that low dose LDM-induced increase of p53 expression and decrease of Oct4 expression in P19 and HCT116-p53(+/+) cells. Knockdown of Oct4 expression by siRNA led to activation of p53 in both cell lines, whereas ectopical expression of Oct4 significantly inhibited p53 expression in P19 cells. LDM-induced p53 activation was blocked by ectopical expression of Oct4. (C) 2014 Elsevier Inc. All rights reserved.

语种: 英语
所属项目编号: 2009ZX0930-010 ; 2009ZX09102-240 ; 7122098
项目资助者: National Science and Technology Major Project Focusing on Drug Innovation from the Ministry of Science and Technology of China ; Beijing Natural Science Foundation
WOS记录号: WOS:000336510900002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53236
Appears in Collections:基础医学院_细胞生物学系_期刊论文

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作者单位: 1.Jinlin Univ, Hosp 1, Dept Oncol, Changchun, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, Dept Cell Biol, Beijing 100191, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Med Anal Ctr, Beijing 100191, Peoples R China
4.Jilin Univ, Bethune Med Coll, Minist Educ, Key Lab Pathobiol, Changchun 310021, Jilin, Peoples R China

Recommended Citation:
Zhen, Hong-Ying,Zhou, Juan,Wu, Hou-Nan,et al. Lidamycin regulates p53 expression by repressing Oct4 transcription[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2014,447(2):224-230.
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