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学科主题: 临床医学
题名:
Changes of histology and capsular collagen in a rat shoulder immobilization model
作者: Liu Yu-lei; Ao Ying-fang; Cui Guo-qing; Zhu Jing-xian
关键词: immobilization ; glenohumeral joint ; subscapular bursa ; frozen shoulder
刊名: CHINESE MEDICAL JOURNAL
发表日期: 2011-12-05
DOI: 10.3760/cma.j.issn.0366-6999.2011.23.019
卷: 124, 期:23, 页:3939-3944
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: JOINT CAPSULE ; ADHESIVE CAPSULITIS ; MATRIX TURNOVER ; RABBIT MODEL ; CONTRACTURE ; TENDON
英文摘要:

Background Shoulder immobilization can induce adhesion of the joint, capsular contracture or lead to the condition of frozen shoulder. However, little is known about the histological effects of immobilization on the shoulder joint. This study aimed to explore the effect of immobility on the subscapular bursa (SSB) and the joint capsular content, including the distribution of types I and III collagen, within an immobilized rat shoulder.

Methods Forty-six Sprague-Dawley rats were randomly divided into one control group (n=6) and four immobilization groups (n=10 in each group), in which the left shoulders were immobilized with plaster for 1, 2, 3 and 4 weeks. At the end of each time point, 2 rats from each group were euthanized and shoulders prepared for serial histological observations of the glenohumeral joints, as well as picrosirius red and immunohistochemical observation of type III collagen. Histological sections of the remaining rat shoulders were used for the immunohistochemical detection of the capsular content of types I and III collagen.

Results The hyperplastic synovium of the anterior capsule obstructed the communication between the SSB and the glenohumeral joint cavity at 2 and 3 weeks. The adhesion of the SSB appeared at 3 and 4 weeks. The quantitative and qualitative results showed that the capsular contents of types I and III collagen progressively increased at 2, 3 and 4 weeks, and that type III collagen was distributed extensively within the joint capsule at 2 and 3 weeks.

Conclusion Immobilization of the rat shoulder induced synovial hyperplasia of the joint capsule, adhesion of the SSB and an increase of the capsular content of types I and III collagen. Chin Med J 2011;124(23):3939-3944

语种: 英语
WOS记录号: WOS:000299061300019
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53238
Appears in Collections:北京大学第三临床医学院_期刊论文

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作者单位: Peking Univ, Hosp 3, Inst Sport Med, Beijing 100191, Peoples R China

Recommended Citation:
Liu Yu-lei,Ao Ying-fang,Cui Guo-qing,et al. Changes of histology and capsular collagen in a rat shoulder immobilization model[J]. CHINESE MEDICAL JOURNAL,2011,124(23):3939-3944.
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