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学科主题: 基础医学
题名:
Reduced expression of Slit2 in renal cell carcinoma
作者: Ma, Wei-Jie1; Zhou, Yu1; Lu, Dan1; Dong, Dong1; Tian, Xiao-Jun2; Wen, Jie-xi1; Zhang, Jun1
关键词: Slit2 ; Renal cell carcinoma ; Methylation ; Tumor suppressor
刊名: MEDICAL ONCOLOGY
发表日期: 2014
DOI: 10.1007/s12032-013-0768-4
卷: 31, 期:1
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: TUMOR-SUPPRESSOR GENES ; FREQUENT EPIGENETIC INACTIVATION ; PROMOTER HYPERMETHYLATION ; METHYLATION ANALYSIS ; CERVICAL-CANCER ; BREAST-CANCER ; AXON GUIDANCE ; GROWTH ; ANGIOGENESIS ; DROSOPHILA
英文摘要:

Slit2, initially identified as an important axon guidance molecule in the nervous system, was suggested to be involved in multiple cellular processes. Recently, Slit2 was reported to function as a potential tumor suppressor in diverse tumors. In this study, we systematically analyzed the expression level of Slit2 in renal cell carcinoma. Compared to paired adjacent non-malignant tissues, both Slit2 mRNA and protein expression were significantly down-regulated in renal cell carcinoma (RCC). Methylation-specific PCR showed that Slit2 promoter was methylated in two renal carcinoma cell lines. Pharmacologic demethylation dramatically induced Slit2 expression in cancer cell lines with weak expression of Slit2. Besides, bisulfite genomic sequencing confirmed that dense methylation existed in Slit2 promoter. Furthermore, in paired RCC samples, Slit2 methylation was observed in 8 out of 38 patients (21.1 %), which was well correlated with the down-regulation of Slit2 in RCC. Therefore, Slit2 may also be a potential tumor suppressor in RCC, which is down-regulated in RCC partially due to promoter methylation.

语种: 英语
所属项目编号: 7122104 ; 81072395
项目资助者: Beijing Municipal Natural Science Foundation ; National Natural Science Foundation of China
WOS记录号: WOS:000328859300005
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53241
Appears in Collections:基础医学院_免疫学系_期刊论文

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作者单位: 1.Peking Univ, Sch Basic Med Sci, Dept Immunol, Key Lab Med Immunol,Minist Hlth,Hlth Sci Ctr, Beijing 100191, Peoples R China
2.Peking Univ, Dept Urol, Hosp 3, Beijing 100191, Peoples R China

Recommended Citation:
Ma, Wei-Jie,Zhou, Yu,Lu, Dan,et al. Reduced expression of Slit2 in renal cell carcinoma[J]. MEDICAL ONCOLOGY,2014,31(1).
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