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Relationship of Serum Interleukin-10 and Its Genetic Variations with Ischemic Stroke in a Chinese General Population
Xie, Gaoqiang1; Myint, Phyo Kyaw2,3,4,5; Zaman, M. Justin S.3,6; Li, Ying7,8,9; Zhao, Liancheng7,8,9; Shi, Ping10; Ren, Fuxiu10; Wu, Yangfeng1,11,12
刊名PLOS ONE
2013-09-11
DOI10.1371/journal.pone.0074126
8期:9
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]DISEASE ; POLYMORPHISMS ; CORONARY ; EVENTS ; RISK ; ATHEROSCLEROSIS ; ASSOCIATION ; COMBINATION ; SHESIS ; IL-10
英文摘要

Background and Purpose: Anti-inflammatory cytokine and its genetic variations may play an important role in the process of atherosclerosis. We assessed whether serum interleukin-10 (IL-10) and its genetic variations are associated with ischemic stroke in a Chinese general population.

Methods: An epidemiological survey on cardiovascular diseases and their risk factors was carried in a general population in Beijing in 2005. Serum IL-10, IL-6, p-selectin, soluble intercellular adhesion molecule-1 and C-reactive protein were analyzed using ELISA kits, while three IL-10 Single Nucleotide Polymorphisms (SNP) (rs1800872, rs1554286 and rs3021094) were genotyped in 1475 participants.

Results: A high serum IL-10 (top tertile) was significantly associated with ischemic stroke (multivariable adjusted odds ratio (OR) =0.50; 95% CI 0.31-0.81). Rs1800872 (AA vs. AC+CC genotype, OR=1.60; 1.06-2.39), rs1554286(TT vs. CT+CC genotype, OR=1.59; 1.06-2.39), and rs3021094 (CC/CA vs. AA genotype, OR=1.64; 1.04-2.60) were all significantly associated with ischemic stroke even after controlling for age, sex, smoking, systolic blood pressure, total cholesterol, glucose, body mass index and serum IL-10. The SNP score (a summary index of these SNPs) and IL-10 (top tertile) together significantly improved the discriminative power in predicting ischemic stroke by 3.3% (95% CI: 0.2-6.4, p=0.0398) compared to predictions based on conventional risk factors alone.

Conclusions: The lower serum IL-10 concentration and its selected genetic variations were significantly associated with an increased likelihood of ischemic stroke in this cross-sectional study. Our results suggest that more prospective studies should be conducted to provide stronger evidence justifying the use of IL-10 and its SNPs as new biomarkers to identify a predisposition towards ischemic stroke.

语种英语
WOS记录号WOS:000326734500073
项目编号2006-yq-006 ; 30471494 ; 30872168 ; 2001BA703B01
资助机构Young Researchers Foundation of Fuwai Hospital ; National Natural Science Foundation of China ; People&prime ; s Republic of China National 10th Five-Year Plan Science and Technology Key Projects
引用统计
被引频次:20[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53245
专题北京大学临床研究所
北京大学医学部管理机构_医学部
作者单位1.Peking Univ, Clin Res Inst, Beijing 100871, Peoples R China
2.Univ Aberdeen, Sch Med & Dent, Inst Appl Hlth Sci, Aberdeen, Scotland
3.Univ E Anglia, Norwich Res Pk Cardiovasc Res Grp, Norwich Med Sch, Norwich NR4 7TJ, Norfolk, England
4.Univ Cambridge, Dept Publ Hlth & Primary Care, Clin Gerontol Unit, Cambridge, England
5.Norfolk & Norwich Univ Hosp, Stroke Res Grp, Norwich, Norfolk, England
6.James Paget Univ Hosp, Dept Cardiol, Great Yarmouth, England
7.Chinese Acad Med Sci, Cardiovasc Inst, Beijing, Peoples R China
8.Chinese Acad Med Sci, Fuwai Hosp, Beijing, Peoples R China
9.Peking Union Med Coll, Beijing, Peoples R China
10.Shijingshan Ctr Dis Control & Prevent, Beijing, Peoples R China
11.Peking Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Beijing 100871, Peoples R China
12.George Inst, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Xie, Gaoqiang,Myint, Phyo Kyaw,Zaman, M. Justin S.,et al. Relationship of Serum Interleukin-10 and Its Genetic Variations with Ischemic Stroke in a Chinese General Population[J]. PLOS ONE,2013,8(9).
APA Xie, Gaoqiang.,Myint, Phyo Kyaw.,Zaman, M. Justin S..,Li, Ying.,Zhao, Liancheng.,...&Wu, Yangfeng.(2013).Relationship of Serum Interleukin-10 and Its Genetic Variations with Ischemic Stroke in a Chinese General Population.PLOS ONE,8(9).
MLA Xie, Gaoqiang,et al."Relationship of Serum Interleukin-10 and Its Genetic Variations with Ischemic Stroke in a Chinese General Population".PLOS ONE 8.9(2013).
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