IR@PKUHSC  > 北京大学深圳医院  > 泌尿外科
学科主题临床医学
Expression and clinical significance of RCDG1 in renal cell carcinoma: A novel renal cancer-associated gene
Yu, Zuhu1,2,3; Ni, Liangchao1; Chen, Duqun1,3; Su, Zhengming1,4; Yu, Wenshui1,4; Zhang, Qiang1; Wang, Yadong1; Li, Cailing2; Gui, Yaoting1,2; Lai, Yongqing1,2
关键词Rcdg1 Renal Cell Carcinoma Western Blot Immunohistochemistry
刊名MOLECULAR MEDICINE REPORTS
2014-09-01
DOI10.3892/mmr.2014.2388
10期:3页:1583-1589
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology ; Medicine, Research & Experimental
资助者National Natural Science Foundation of China ; Medical Scientific Research Foundation of Guangdong Province of China ; Science and Technology Development Fund Project of Shenzhen ; National Natural Science Foundation of China ; Medical Scientific Research Foundation of Guangdong Province of China ; Science and Technology Development Fund Project of Shenzhen
研究领域[WOS]Oncology ; Research & Experimental Medicine
关键词[WOS]CARBONIC-ANHYDRASE-IX ; PROGNOSIS ; THERAPY ; VHL ; IDENTIFICATION ; FEATURES ; ADULTS
英文摘要

Recently identified molecular tumor markers have numerous potential applications in the diagnosis, therapy and prognostic prediction of renal cell carcinoma (RCC). Through bioinformatics-based screening approaches together with validation of western blot and immunohistochemical data, the present study identified a novel renal cancer-associated gene, preliminarily named Renal Cancer Differentiation Gene 1 (RCDG1), originally known as chromosome 4 open reading frame 46 (C4orf46). RCDG1 expression was evaluated by western blot analysis of RCC and adjacent normal tissues, renal cancer cell lines and normal kidney HEK293T cells. Additionally, RCDG1 expression was assessed in 124 RCC paraffin sections, including 92 paired adjacent normal tissues, by immunohistochemistry. The results showed that RCDG1 was significantly downregulated in RCC tissues as compared with normal adjacent tissues (P<0.001), and the expression of RCDG1 in clear cell (cc) RCC tissues was significantly lower as compared with that of non-ccRCC tissues (P=0.005). Furthermore, statistical analysis revealed RCDG1 expression was negatively correlated with the Fuhrman grade in ccRCC (P=0.008). A reduction in RCDG1 expression may be associated with the oncogenesis of RCC and the differentiation of ccRCC. Further studies may provide more information about the function of RCDG1 gene in RCC.

语种英语
所属项目编号81101922 ; A2012584 ; A2013606 ; JCYJ20130402114702124
资助者National Natural Science Foundation of China ; Medical Scientific Research Foundation of Guangdong Province of China ; Science and Technology Development Fund Project of Shenzhen ; National Natural Science Foundation of China ; Medical Scientific Research Foundation of Guangdong Province of China ; Science and Technology Development Fund Project of Shenzhen
WOS记录号WOS:000340854500061
Citation statistics
Cited Times:4[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53249
Collection北京大学深圳医院_泌尿外科
作者单位1.Anhui Med Univ, Hefei 230032, Anhui, Peoples R China
2.Peking Univ, Shenzhen Hosp, Dept Urol, Shenzhen 518036, Guangdong, Peoples R China
3.Peking Univ, Shenzhen PKU HKUST Med Ctr, Guangdong & Shenzhen Key Lab Male Reprod Med & Ge, Key Lab Stem Cell Biol,Inst Urol,Shenzhen Hosp, Shenzhen 518036, Guangdong, Peoples R China
4.Shantou Univ, Coll Med, Shantou 515041, Guangdong, Peoples R China
Recommended Citation
GB/T 7714
Yu, Zuhu,Ni, Liangchao,Chen, Duqun,et al. Expression and clinical significance of RCDG1 in renal cell carcinoma: A novel renal cancer-associated gene[J]. MOLECULAR MEDICINE REPORTS,2014,10(3):1583-1589.
APA Yu, Zuhu.,Ni, Liangchao.,Chen, Duqun.,Su, Zhengming.,Yu, Wenshui.,...&Lai, Yongqing.(2014).Expression and clinical significance of RCDG1 in renal cell carcinoma: A novel renal cancer-associated gene.MOLECULAR MEDICINE REPORTS,10(3),1583-1589.
MLA Yu, Zuhu,et al."Expression and clinical significance of RCDG1 in renal cell carcinoma: A novel renal cancer-associated gene".MOLECULAR MEDICINE REPORTS 10.3(2014):1583-1589.
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