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学科主题: 临床医学
题名:
Expression and clinical significance of RCDG1 in renal cell carcinoma: A novel renal cancer-associated gene
作者: Yu, Zuhu1,2,3; Ni, Liangchao1; Chen, Duqun1,3; Su, Zhengming1,4; Yu, Wenshui1,4; Zhang, Qiang1; Wang, Yadong1; Li, Cailing2; Gui, Yaoting1,2; Lai, Yongqing1,2
关键词: RCDG1 ; renal cell carcinoma ; western blot ; immunohistochemistry
刊名: MOLECULAR MEDICINE REPORTS
发表日期: 2014-09-01
DOI: 10.3892/mmr.2014.2388
卷: 10, 期:3, 页:1583-1589
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology ; Medicine, Research & Experimental
研究领域[WOS]: Oncology ; Research & Experimental Medicine
关键词[WOS]: CARBONIC-ANHYDRASE-IX ; PROGNOSIS ; THERAPY ; VHL ; IDENTIFICATION ; FEATURES ; ADULTS
英文摘要:

Recently identified molecular tumor markers have numerous potential applications in the diagnosis, therapy and prognostic prediction of renal cell carcinoma (RCC). Through bioinformatics-based screening approaches together with validation of western blot and immunohistochemical data, the present study identified a novel renal cancer-associated gene, preliminarily named Renal Cancer Differentiation Gene 1 (RCDG1), originally known as chromosome 4 open reading frame 46 (C4orf46). RCDG1 expression was evaluated by western blot analysis of RCC and adjacent normal tissues, renal cancer cell lines and normal kidney HEK293T cells. Additionally, RCDG1 expression was assessed in 124 RCC paraffin sections, including 92 paired adjacent normal tissues, by immunohistochemistry. The results showed that RCDG1 was significantly downregulated in RCC tissues as compared with normal adjacent tissues (P<0.001), and the expression of RCDG1 in clear cell (cc) RCC tissues was significantly lower as compared with that of non-ccRCC tissues (P=0.005). Furthermore, statistical analysis revealed RCDG1 expression was negatively correlated with the Fuhrman grade in ccRCC (P=0.008). A reduction in RCDG1 expression may be associated with the oncogenesis of RCC and the differentiation of ccRCC. Further studies may provide more information about the function of RCDG1 gene in RCC.

语种: 英语
所属项目编号: 81101922 ; A2012584 ; A2013606 ; JCYJ20130402114702124
项目资助者: National Natural Science Foundation of China ; Medical Scientific Research Foundation of Guangdong Province of China ; Science and Technology Development Fund Project of Shenzhen
WOS记录号: WOS:000340854500061
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53249
Appears in Collections:北京大学深圳医院_泌尿外科_期刊论文

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作者单位: 1.Anhui Med Univ, Hefei 230032, Anhui, Peoples R China
2.Peking Univ, Shenzhen Hosp, Dept Urol, Shenzhen 518036, Guangdong, Peoples R China
3.Peking Univ, Shenzhen PKU HKUST Med Ctr, Guangdong & Shenzhen Key Lab Male Reprod Med & Ge, Key Lab Stem Cell Biol,Inst Urol,Shenzhen Hosp, Shenzhen 518036, Guangdong, Peoples R China
4.Shantou Univ, Coll Med, Shantou 515041, Guangdong, Peoples R China

Recommended Citation:
Yu, Zuhu,Ni, Liangchao,Chen, Duqun,et al. Expression and clinical significance of RCDG1 in renal cell carcinoma: A novel renal cancer-associated gene[J]. MOLECULAR MEDICINE REPORTS,2014,10(3):1583-1589.
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