IR@PKUHSC  > 北京大学深圳医院  > 泌尿外科
学科主题临床医学
Expression and clinical significance of RCDG1 in renal cell carcinoma: A novel renal cancer-associated gene
Yu, Zuhu1,2,3; Ni, Liangchao1; Chen, Duqun1,3; Su, Zhengming1,4; Yu, Wenshui1,4; Zhang, Qiang1; Wang, Yadong1; Li, Cailing2; Gui, Yaoting1,2; Lai, Yongqing1,2
关键词Rcdg1 Renal Cell Carcinoma Western Blot Immunohistochemistry
刊名MOLECULAR MEDICINE REPORTS
2014-09-01
DOI10.3892/mmr.2014.2388
10期:3页:1583-1589
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology ; Medicine, Research & Experimental
研究领域[WOS]Oncology ; Research & Experimental Medicine
关键词[WOS]CARBONIC-ANHYDRASE-IX ; PROGNOSIS ; THERAPY ; VHL ; IDENTIFICATION ; FEATURES ; ADULTS
英文摘要

Recently identified molecular tumor markers have numerous potential applications in the diagnosis, therapy and prognostic prediction of renal cell carcinoma (RCC). Through bioinformatics-based screening approaches together with validation of western blot and immunohistochemical data, the present study identified a novel renal cancer-associated gene, preliminarily named Renal Cancer Differentiation Gene 1 (RCDG1), originally known as chromosome 4 open reading frame 46 (C4orf46). RCDG1 expression was evaluated by western blot analysis of RCC and adjacent normal tissues, renal cancer cell lines and normal kidney HEK293T cells. Additionally, RCDG1 expression was assessed in 124 RCC paraffin sections, including 92 paired adjacent normal tissues, by immunohistochemistry. The results showed that RCDG1 was significantly downregulated in RCC tissues as compared with normal adjacent tissues (P<0.001), and the expression of RCDG1 in clear cell (cc) RCC tissues was significantly lower as compared with that of non-ccRCC tissues (P=0.005). Furthermore, statistical analysis revealed RCDG1 expression was negatively correlated with the Fuhrman grade in ccRCC (P=0.008). A reduction in RCDG1 expression may be associated with the oncogenesis of RCC and the differentiation of ccRCC. Further studies may provide more information about the function of RCDG1 gene in RCC.

语种英语
WOS记录号WOS:000340854500061
项目编号81101922 ; A2012584 ; A2013606 ; JCYJ20130402114702124
资助机构National Natural Science Foundation of China ; Medical Scientific Research Foundation of Guangdong Province of China ; Science and Technology Development Fund Project of Shenzhen
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53249
专题北京大学深圳医院_泌尿外科
作者单位1.Anhui Med Univ, Hefei 230032, Anhui, Peoples R China
2.Peking Univ, Shenzhen Hosp, Dept Urol, Shenzhen 518036, Guangdong, Peoples R China
3.Peking Univ, Shenzhen PKU HKUST Med Ctr, Guangdong & Shenzhen Key Lab Male Reprod Med & Ge, Key Lab Stem Cell Biol,Inst Urol,Shenzhen Hosp, Shenzhen 518036, Guangdong, Peoples R China
4.Shantou Univ, Coll Med, Shantou 515041, Guangdong, Peoples R China
推荐引用方式
GB/T 7714
Yu, Zuhu,Ni, Liangchao,Chen, Duqun,et al. Expression and clinical significance of RCDG1 in renal cell carcinoma: A novel renal cancer-associated gene[J]. MOLECULAR MEDICINE REPORTS,2014,10(3):1583-1589.
APA Yu, Zuhu.,Ni, Liangchao.,Chen, Duqun.,Su, Zhengming.,Yu, Wenshui.,...&Lai, Yongqing.(2014).Expression and clinical significance of RCDG1 in renal cell carcinoma: A novel renal cancer-associated gene.MOLECULAR MEDICINE REPORTS,10(3),1583-1589.
MLA Yu, Zuhu,et al."Expression and clinical significance of RCDG1 in renal cell carcinoma: A novel renal cancer-associated gene".MOLECULAR MEDICINE REPORTS 10.3(2014):1583-1589.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Yu, Zuhu]的文章
[Ni, Liangchao]的文章
[Chen, Duqun]的文章
百度学术
百度学术中相似的文章
[Yu, Zuhu]的文章
[Ni, Liangchao]的文章
[Chen, Duqun]的文章
必应学术
必应学术中相似的文章
[Yu, Zuhu]的文章
[Ni, Liangchao]的文章
[Chen, Duqun]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。