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学科主题: 口腔医学
题名:
Microbiome interaction with sugar plays an important role in relapse of childhood caries
作者: Tian, Jing1; Qin, Man1; Ma, Wenli1; Xia, Bin1; Xu, He1; Zhang, Qian2; Chen, Feng2
关键词: Caries ; Recurrence ; High-throughput nucleotide sequencing ; Microbiota ; Forecasting ; Diet ; Cariogenic
刊名: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
发表日期: 2015-12-04
DOI: 10.1016/j.bbrc.2015.10.110
卷: 468, 期:1-2, 页:294-299
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]: Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]: DENTAL-CARIES ; PYROSEQUENCING ANALYSIS ; ORAL MICROBIOTA ; CHILDREN ; DIET
英文摘要:

Childhood caries have a high relapse rate after full mouth therapy. This study aimed to elucidate the relationship between the microbiome, sugar, and the relapse of childhood caries after therapy. A total of 24 children aged 2-4 years who underwent one caries treatment session participated in this study. Supragingival plaque was collected before therapy and 1 and 7 months after therapy, then sequenced using the 16S rRNA high-throughput approach. We found 11 phyla, 140 genera, and 444 species in 72 samples. The children were divided into relapse-free (n = 13) and relapse (n = 11) groups according to whether they relapsed 7 months after therapy. The bacterial community richness, diversity, structure, and relative abundance of bacterial taxa were significantly different between the two groups 7 months after therapy. The two groups also differed in the relative abundance of bacterial taxa, both before and 1 month after therapy. Bacterial community richness and diversity were lower in the relapse-free group 1 month after therapy. Using different operational taxonomic units between the relapse-free and relapse groups 1 month after therapy, a relapse-risk assessment model was built with 75% accuracy, 0.1905 out-of-bag error, and 66.67% validation accuracy. Patients in the relapse group had higher sugar intake frequencies than those in the relapse-free group during follow-up. Interactions between the microbiome and sugar intake frequency were found through co-occurrence networks. We conclude that the microbiome is significantly different between the relapse-free and relapse groups at the time of relapse. Supragingival plaque collected immediately after therapy can be used to predict the risk of relapse. Furthermore, the correlation between sugar intake frequency and microbiome is associated with the relapse. (C) 2015 Elsevier Inc. All rights reserved.

语种: 英语
所属项目编号: Z121107001012028 ; Z141107002514058
项目资助者: Capital Clinical Characteristics Applied Research Projects - Beijing Municipal Science &amp ; Technology Commission ; Construction Project of the National Key Discipline of Pediatric Dentistry - Ministry of Health P.R. China
WOS记录号: WOS:000366240800047
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53250
Appears in Collections:北京大学口腔医学院_儿童口腔科_期刊论文

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作者单位: 1.Peking Univ, Sch & Hosp Stomatol, Dept Pediat Dent, Beijing 100081, Peoples R China
2.Peking Univ, Sch & Hosp Stomatol, Cent Lab, Beijing 100081, Peoples R China

Recommended Citation:
Tian, Jing,Qin, Man,Ma, Wenli,et al. Microbiome interaction with sugar plays an important role in relapse of childhood caries[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2015,468(1-2):294-299.
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