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学科主题口腔医学
Microbiome interaction with sugar plays an important role in relapse of childhood caries
Tian, Jing1; Qin, Man1; Ma, Wenli1; Xia, Bin1; Xu, He1; Zhang, Qian2; Chen, Feng2
关键词Caries Recurrence High-throughput Nucleotide Sequencing Microbiota Forecasting Diet Cariogenic
刊名BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
2015-12-04
DOI10.1016/j.bbrc.2015.10.110
468期:1-2页:294-299
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]DENTAL-CARIES ; PYROSEQUENCING ANALYSIS ; ORAL MICROBIOTA ; CHILDREN ; DIET
英文摘要

Childhood caries have a high relapse rate after full mouth therapy. This study aimed to elucidate the relationship between the microbiome, sugar, and the relapse of childhood caries after therapy. A total of 24 children aged 2-4 years who underwent one caries treatment session participated in this study. Supragingival plaque was collected before therapy and 1 and 7 months after therapy, then sequenced using the 16S rRNA high-throughput approach. We found 11 phyla, 140 genera, and 444 species in 72 samples. The children were divided into relapse-free (n = 13) and relapse (n = 11) groups according to whether they relapsed 7 months after therapy. The bacterial community richness, diversity, structure, and relative abundance of bacterial taxa were significantly different between the two groups 7 months after therapy. The two groups also differed in the relative abundance of bacterial taxa, both before and 1 month after therapy. Bacterial community richness and diversity were lower in the relapse-free group 1 month after therapy. Using different operational taxonomic units between the relapse-free and relapse groups 1 month after therapy, a relapse-risk assessment model was built with 75% accuracy, 0.1905 out-of-bag error, and 66.67% validation accuracy. Patients in the relapse group had higher sugar intake frequencies than those in the relapse-free group during follow-up. Interactions between the microbiome and sugar intake frequency were found through co-occurrence networks. We conclude that the microbiome is significantly different between the relapse-free and relapse groups at the time of relapse. Supragingival plaque collected immediately after therapy can be used to predict the risk of relapse. Furthermore, the correlation between sugar intake frequency and microbiome is associated with the relapse. (C) 2015 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000366240800047
项目编号Z121107001012028 ; Z141107002514058
资助机构Capital Clinical Characteristics Applied Research Projects - Beijing Municipal Science &amp ; Technology Commission ; Construction Project of the National Key Discipline of Pediatric Dentistry - Ministry of Health P.R. China
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53250
专题北京大学口腔医学院_儿童口腔科
作者单位1.Peking Univ, Sch & Hosp Stomatol, Dept Pediat Dent, Beijing 100081, Peoples R China
2.Peking Univ, Sch & Hosp Stomatol, Cent Lab, Beijing 100081, Peoples R China
推荐引用方式
GB/T 7714
Tian, Jing,Qin, Man,Ma, Wenli,et al. Microbiome interaction with sugar plays an important role in relapse of childhood caries[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2015,468(1-2):294-299.
APA Tian, Jing.,Qin, Man.,Ma, Wenli.,Xia, Bin.,Xu, He.,...&Chen, Feng.(2015).Microbiome interaction with sugar plays an important role in relapse of childhood caries.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,468(1-2),294-299.
MLA Tian, Jing,et al."Microbiome interaction with sugar plays an important role in relapse of childhood caries".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 468.1-2(2015):294-299.
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