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学科主题: 临床医学
题名:
Ketamine-Associated Urinary Tract Dysfunction: An Underrecognized Clinical Entity
作者: Lai, Yongqing1,2; Wua, Song1,2; Ni, Liangchao1,2; Chen, Zebo1,2; Li, Xianxin1,2; Yang, Shangqi1,2; Gui, Yaoting2; Guan, Zhichen1; Cai, Zhiming1,2; Ye, Jiongxian1,2
关键词: Adult ; Bladder dysfunction ; Urinary bladder ; Urodynamic study ; Voiding dysfunction ; Ketamine ; Bladder dysfunction
刊名: UROLOGIA INTERNATIONALIS
发表日期: 2012
DOI: 10.1159/000338098
卷: 89, 期:1, 页:93-96
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Urology & Nephrology
研究领域[WOS]: Urology & Nephrology
关键词[WOS]: BLADDER DYSFUNCTION ; CYSTITIS
英文摘要:

Introduction: The use of ketamine as a recreational drug is on the increase among young adults attending clubs and parties. Recreational ketamine users have anecdotally reported increased lower urinary tract symptoms while using the substance. Methods: We describe the severe lower urinary tract symptoms experienced in 6 patients with chronic recreational ketannine use. We obtained a detailed history and physical examination along with further investigation to identify a relationship between recreational ketamine use and these symptoms. Results:The urine cultures were sterile in all cases. Intravenous urography was performed in 3 patients and demonstrated bilateral upper ureteric narrow, mild bilateral hydronephrosis and contracted bladder urodynamic studies showed detrusor instability with urinary leakage when the bladder was filled to a capacity of 30-50 ml. Cystoscopy revealed a small capacity bladder with erythematous lesions throughout the bladder. Bladder biopsies were performed in 3 patients and showed up as chronic cystitis. Ketamine cessation along with intravesical sodium hyaluronate solution appeared to provide some symptomatic relief. Conclusion: Ketamine-associated urinary tract dysfunction appears to be a relatively new clinical phenomenon. The pathological mechanism of ketamine-associated urinary tract dysfunction is unknown and current management strategies are ketamine cessation along with intravesical sodium hyaluronate solution. Copyright (C) 2012 S. Karger AG, Basel

语种: 英语
所属项目编号: 81101922
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000306888100016
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53252
Appears in Collections:北京大学深圳医院_泌尿外科_期刊论文

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作者单位: 1.Peking Univ, Shenzhen Hosp, Dept Urol, Shenzhen PKU HKUST Med Ctr,Inst Urol, Shenzhen 518036, Peoples R China
2.Peking Univ, Shenzhen Hosp, Key Lab Stem Cell Biol,Guangdon & Shenzhen Key La, Shenzhen PKU HKUST Med Ctr,Inst Urol, Shenzhen 518036, Peoples R China

Recommended Citation:
Lai, Yongqing,Wua, Song,Ni, Liangchao,et al. Ketamine-Associated Urinary Tract Dysfunction: An Underrecognized Clinical Entity[J]. UROLOGIA INTERNATIONALIS,2012,89(1):93-96.
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