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学科主题临床医学
Influence of Lymphocyte Recovery on Outcome of Haploidentical Transplantation for Hematologic Malignancies
Chang, Ying-Jun1,2; Zhao, Xiang-Yu1; Huo, Ming-Rui1; Xu, Lan-Ping1; Liu, Dai-Hong1; Liu, Kai-Yan1; Huang, Xiao-Jun1
刊名MEDICINE
2009-11-01
DOI10.1097/MD.0b013e3181c167e2
88期:6页:322-330
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal
资助者National Outstanding Young Scientist&prime ; s Foundation of China ; Hi-Tech Research and Development Program of China ; Program for Innovative Research Team in University ; National Outstanding Young Scientist&prime ; s Foundation of China ; Hi-Tech Research and Development Program of China ; Program for Innovative Research Team in University
研究领域[WOS]General & Internal Medicine
关键词[WOS]STEM-CELL TRANSPLANTATION ; BONE-MARROW-TRANSPLANTATION ; VERSUS-HOST-DISEASE ; PREDICTS SUPERIOR SURVIVAL ; NON-HODGKINS-LYMPHOMA ; ACUTE LYMPHOBLASTIC-LEUKEMIA ; MULTIPLE-MYELOMA ; IMMUNE RECONSTITUTION ; CHRONIC GRAFT ; T-CELLS
英文摘要

Unmanipulated human leukocyte antigen (HLA)-mismatched/haploidentical blood and marrow transplantation is an established treatment for patients without HLA-matched related or unrelated donors. However, the prognostic significance of early lymphocyte recovery in this transplant setting is not defined. In this study, we investigated the association of day 30 absolute lymphocyte count (ALC-30) with outcome after unmanipulated HLA-mismatched/haploidentical transplantation. We prospectively analyzed the relationship between ALC-30 and transplant outcomes in 206 patients with hematologic malignancies receiving T-cell-replete transplantation from HLA-mismatched/haploidentical related donors. Multivariate analysis showed that ALC-30 above the cutoff value of 300 cells/mu L was associated with improved overall survival (hazard ratio [HR], 0.258; 95% confidence interval [CI], 0.141-0.472; p < 0.0001); improved cancer-free survival (HR, 0.289i 95% CL 0.166-0.501; p < 0.0001); reduced relapse (HR, 0.370; 95% CL 0.161-0.853; p = 0.020); and decreased transplant-related mortality (HR, 0.211; 95% CI, 0.097-0.457; p < 0.0001). Our results suggest that the recovery of ALC-30 might have an influence on transplant outcomes following unmanipulated HLA-mismatched/haploidentical transplantation.

语种英语
所属项目编号30725038 ; 2006AA02Z4A0 ; IRT0702
资助者National Outstanding Young Scientist&prime ; s Foundation of China ; Hi-Tech Research and Development Program of China ; Program for Innovative Research Team in University ; National Outstanding Young Scientist&prime ; s Foundation of China ; Hi-Tech Research and Development Program of China ; Program for Innovative Research Team in University
WOS记录号WOS:000272021300002
引用统计
被引频次:15[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53259
专题北京大学第二临床医学院_血液科
作者单位1.Peking Univ, Peking Univ Peoples Hosp, Inst Hematol, Beijing 100044, Peoples R China
2.Hebei Med Univ, Affiliated Hosp 3, Dept Hematol, Shijiazhuang, Peoples R China
推荐引用方式
GB/T 7714
Chang, Ying-Jun,Zhao, Xiang-Yu,Huo, Ming-Rui,et al. Influence of Lymphocyte Recovery on Outcome of Haploidentical Transplantation for Hematologic Malignancies[J]. MEDICINE,2009,88(6):322-330.
APA Chang, Ying-Jun.,Zhao, Xiang-Yu.,Huo, Ming-Rui.,Xu, Lan-Ping.,Liu, Dai-Hong.,...&Huang, Xiao-Jun.(2009).Influence of Lymphocyte Recovery on Outcome of Haploidentical Transplantation for Hematologic Malignancies.MEDICINE,88(6),322-330.
MLA Chang, Ying-Jun,et al."Influence of Lymphocyte Recovery on Outcome of Haploidentical Transplantation for Hematologic Malignancies".MEDICINE 88.6(2009):322-330.
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