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学科主题: 基础医学
题名:
Electroacupuncture Treatment Normalized Sleep Disturbance in Morphine Withdrawal Rats
作者: Li, Yi-Jing1; Zhong, Fei1; Yu, Peng1; Han, Ji-Sheng1; Cui, Cai-Lian1; Wu, Liu-Zhen1
刊名: EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
发表日期: 2011
DOI: 10.1093/ecam/nep133
期: 5, 页:1-8
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Integrative & Complementary Medicine
研究领域[WOS]: Integrative & Complementary Medicine
关键词[WOS]: VENTROLATERAL PREOPTIC NUCLEUS ; LOCUS-COERULEUS NEURONS ; ACUTE HEROIN ABSTINENCE ; IN-VIVO MICRODIALYSIS ; OPIATE WITHDRAWAL ; DIFFERENT FREQUENCIES ; OPIOID RECEPTOR ; MESSENGER-RNA ; ADDICTS ; EXPRESSION
英文摘要:

Sleep disturbance is considered as an important symptom of acute and protracted opiate withdrawal. Current results suggest that sleep disturbance may be taken as a predictor of relapse. Appropriate sleep enhancement therapy will be in favor of the retention in treatment for opiate addicts. Our previous studies have shown that electroacupuncture (EA) is effective in suppressing morphine withdrawal syndrome. The aim of the present study is to investigate the effect of 2 and 100 Hz EA on the sleep disturbance during morphine withdrawal. Rats were made dependent on morphine by repeated morphine injections (escalating doses of 5-80 mgkg(-1), subcutaneously, twice a day) for 5 days. EA of 2 or 100 Hz was given twice a day for 3 days, starting at 48 h after the last morphine injection. Electroencephalogram and electromyogram were monitored at the end of the first and the last EA treatments, respectively. Results showed that non-rapid eye movement (NREM) sleep, REM sleep and total sleep time decreased dramatically, while the sleep latency prolonged significantly during acute morphine withdrawal. Both 2 and 100 Hz EA produced a significant increase in NREM sleep, REM sleep and total sleep time. It was suggested that EA could be a potential treatment for sleep disturbance during morphine withdrawal.

语种: 英语
所属项目编号: 2009CB522003 ; 30770690
项目资助者: National Basic Research Program ; National Natural Science Foundation of China
WOS记录号: WOS:000293415400001
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53260
Appears in Collections:基础医学院_神经生物学系_期刊论文

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作者单位: 1.Minist Publ Hlth, Key Lab Neurosci, Beijing 100191, Peoples R China
2.Peking Univ, Neurosci Res Inst, Sch Basic Med Sci, Key Lab Neurosci,Dept Neurobiol,Minist Educ, Beijing 100191, Peoples R China

Recommended Citation:
Li, Yi-Jing,Zhong, Fei,Yu, Peng,et al. Electroacupuncture Treatment Normalized Sleep Disturbance in Morphine Withdrawal Rats[J]. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,2011(5):1-8.
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