IR@PKUHSC  > 北京大学基础医学院  > 神经生物学系
学科主题基础医学
Electroacupuncture Treatment Normalized Sleep Disturbance in Morphine Withdrawal Rats
Li, Yi-Jing1; Zhong, Fei1; Yu, Peng1; Han, Ji-Sheng1; Cui, Cai-Lian1; Wu, Liu-Zhen1
刊名EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
2011
DOI10.1093/ecam/nep133
5页:1-8
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Integrative & Complementary Medicine
资助者National Basic Research Program ; National Natural Science Foundation of China ; National Basic Research Program ; National Natural Science Foundation of China
研究领域[WOS]Integrative & Complementary Medicine
关键词[WOS]VENTROLATERAL PREOPTIC NUCLEUS ; LOCUS-COERULEUS NEURONS ; ACUTE HEROIN ABSTINENCE ; IN-VIVO MICRODIALYSIS ; OPIATE WITHDRAWAL ; DIFFERENT FREQUENCIES ; OPIOID RECEPTOR ; MESSENGER-RNA ; ADDICTS ; EXPRESSION
英文摘要

Sleep disturbance is considered as an important symptom of acute and protracted opiate withdrawal. Current results suggest that sleep disturbance may be taken as a predictor of relapse. Appropriate sleep enhancement therapy will be in favor of the retention in treatment for opiate addicts. Our previous studies have shown that electroacupuncture (EA) is effective in suppressing morphine withdrawal syndrome. The aim of the present study is to investigate the effect of 2 and 100 Hz EA on the sleep disturbance during morphine withdrawal. Rats were made dependent on morphine by repeated morphine injections (escalating doses of 5-80 mgkg(-1), subcutaneously, twice a day) for 5 days. EA of 2 or 100 Hz was given twice a day for 3 days, starting at 48 h after the last morphine injection. Electroencephalogram and electromyogram were monitored at the end of the first and the last EA treatments, respectively. Results showed that non-rapid eye movement (NREM) sleep, REM sleep and total sleep time decreased dramatically, while the sleep latency prolonged significantly during acute morphine withdrawal. Both 2 and 100 Hz EA produced a significant increase in NREM sleep, REM sleep and total sleep time. It was suggested that EA could be a potential treatment for sleep disturbance during morphine withdrawal.

语种英语
所属项目编号2009CB522003 ; 30770690
资助者National Basic Research Program ; National Natural Science Foundation of China ; National Basic Research Program ; National Natural Science Foundation of China
WOS记录号WOS:000293415400001
Citation statistics
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53260
Collection北京大学基础医学院_神经生物学系
作者单位1.Minist Publ Hlth, Key Lab Neurosci, Beijing 100191, Peoples R China
2.Peking Univ, Neurosci Res Inst, Sch Basic Med Sci, Key Lab Neurosci,Dept Neurobiol,Minist Educ, Beijing 100191, Peoples R China
Recommended Citation
GB/T 7714
Li, Yi-Jing,Zhong, Fei,Yu, Peng,et al. Electroacupuncture Treatment Normalized Sleep Disturbance in Morphine Withdrawal Rats[J]. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,2011(5):1-8.
APA Li, Yi-Jing,Zhong, Fei,Yu, Peng,Han, Ji-Sheng,Cui, Cai-Lian,&Wu, Liu-Zhen.(2011).Electroacupuncture Treatment Normalized Sleep Disturbance in Morphine Withdrawal Rats.EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE(5),1-8.
MLA Li, Yi-Jing,et al."Electroacupuncture Treatment Normalized Sleep Disturbance in Morphine Withdrawal Rats".EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE .5(2011):1-8.
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