IR@PKUHSC  > 北京大学第三临床医学院  > 血液内科
学科主题临床医学
Clinical and laboratory characteristics of systemic anaplastic large cell lymphoma in Chinese patients
Wang, Yan-Fang1,2; Yang, Yan-Li1,2; Gao, Zi-Fen3; Zhou, Chun-Ju4; Gregg, Xylina5; Shi, Yun-Fei3; Wang, Jing1,2; Yang, Xiao-Feng6; Ke, Xiao-Yan1,2
关键词Systemic Anaplastic Large Cell Lymphoma Prognosis Anaplastic Lymphoma Kinase Ki-67 Bcl-2 Wt1
刊名JOURNAL OF HEMATOLOGY & ONCOLOGY
2012-07-07
DOI10.1186/1756-8722-5-38
5
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology ; Hematology
研究领域[WOS]Oncology ; Hematology
关键词[WOS]APOPTOSIS-RELATED PROTEINS ; BCL-2 FAMILY PROTEINS ; NON-HODGKINS-LYMPHOMA ; T-CELL ; EXPRESSION LEVELS ; DIFFERENTIAL EXPRESSION ; PROGNOSTIC-SIGNIFICANCE ; ALK ; DISEASE ; ADULTS
英文摘要

Background: Systemic anaplastic large cell lymphoma (S-ALCL) is a rare disease with a highly variable prognosis and no standard chemotherapy regimen. Anaplastic lymphoma kinase (ALK) has been reported as an important prognostic factor correlated with S-ALCL in many but not all studies. In our study, we retrospectively analyzed 92 patients with S-ALCL from the Peking University Lymphoma Center for clinical and molecular prognostic factors to make clear the role of ALK and other prognostic factors in Han Chinese S-ALCL.

Results: The majority of Chinese S-ALCL patients were young male patients (median age 26, male/female ratio 1.7) and the median age was younger than previous reports regardless of ALK expression status. The only statistically significant different clinical characteristic in S-ALCL between ALK positive (ALK(+)) and ALK negative (ALK(-)) was age, with a younger median age of 22 for ALK+ compared with 30 for ALK-. However, when pediatric patients (<= 18) were excluded, there was no age difference between ALK+ and ALK-. The groups did not differ in the proportion of males, those with clinical stage III/IV (49 vs 51%) or those with extranodal disease (53 vs 59%). Of 73 evaluable patients, the 3-year and 5-year survival rates were 60% and 47%, respectively. Univariate analysis showed that three factors: advanced stage III/IV, lack of expression of ALK, and high Ki-67 expression, were associated with treatment failure in patients with S-ALCL. However, ALK expression correlated with improved survival only in patients younger than 14 years, while not in adult patients. In multivariate analysis, only clinical stage was an independent prognostic factor for survival. Expressions of Wilms tumor 1 (WT1) and B-cell lymphoma 2 protein (BCL-2) correlated with the expression of ALK, but they did not have prognostic significance. High Ki-67 expression was also a poor prognostic factor.

Conclusions: Our results show that ALK expression alone is not sufficient to determine the outcome of ALCL and other prognostic factors must be considered. Clinical stage is an independent prognostic factor. Ki-67 expression is a promising prognostic factor.

语种英语
WOS记录号WOS:000307871100001
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53262
专题北京大学第三临床医学院_血液内科
北京大学基础医学院
北京大学第二临床医学院_血液科
北京大学临床肿瘤学院_病理科
作者单位1.Peking Univ, Hosp 3, Dept Hematol, Beijing 100191, Peoples R China
2.Peking Univ, Hosp 3, Lymphoma Res Ctr, Beijing 100191, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Dept Pathol, Beijing 100191, Peoples R China
4.Beijing Childrens Hosp, Dept Pathol, Beijing 100045, Peoples R China
5.Utah Canc Specialists, Salt Lake City, UT 84106 USA
6.Temple Univ, Sch Med, Dept Pharmacol, Philadelphia, PA 19140 USA
推荐引用方式
GB/T 7714
Wang, Yan-Fang,Yang, Yan-Li,Gao, Zi-Fen,et al. Clinical and laboratory characteristics of systemic anaplastic large cell lymphoma in Chinese patients[J]. JOURNAL OF HEMATOLOGY &amp; ONCOLOGY,2012,5.
APA Wang, Yan-Fang.,Yang, Yan-Li.,Gao, Zi-Fen.,Zhou, Chun-Ju.,Gregg, Xylina.,...&Ke, Xiao-Yan.(2012).Clinical and laboratory characteristics of systemic anaplastic large cell lymphoma in Chinese patients.JOURNAL OF HEMATOLOGY & ONCOLOGY,5.
MLA Wang, Yan-Fang,et al."Clinical and laboratory characteristics of systemic anaplastic large cell lymphoma in Chinese patients".JOURNAL OF HEMATOLOGY & ONCOLOGY 5(2012).
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