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学科主题: 临床医学
题名:
Clinical and laboratory characteristics of systemic anaplastic large cell lymphoma in Chinese patients
作者: Wang, Yan-Fang1,2; Yang, Yan-Li1,2; Gao, Zi-Fen3; Zhou, Chun-Ju4; Gregg, Xylina5; Shi, Yun-Fei3; Wang, Jing1,2; Yang, Xiao-Feng6; Ke, Xiao-Yan1,2
关键词: Systemic anaplastic large cell lymphoma ; Prognosis ; Anaplastic lymphoma kinase ; Ki-67 ; BCL-2 ; WT1
刊名: JOURNAL OF HEMATOLOGY & ONCOLOGY
发表日期: 2012-07-07
DOI: 10.1186/1756-8722-5-38
卷: 5
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology ; Hematology
研究领域[WOS]: Oncology ; Hematology
关键词[WOS]: APOPTOSIS-RELATED PROTEINS ; BCL-2 FAMILY PROTEINS ; NON-HODGKINS-LYMPHOMA ; T-CELL ; EXPRESSION LEVELS ; DIFFERENTIAL EXPRESSION ; PROGNOSTIC-SIGNIFICANCE ; ALK ; DISEASE ; ADULTS
英文摘要:

Background: Systemic anaplastic large cell lymphoma (S-ALCL) is a rare disease with a highly variable prognosis and no standard chemotherapy regimen. Anaplastic lymphoma kinase (ALK) has been reported as an important prognostic factor correlated with S-ALCL in many but not all studies. In our study, we retrospectively analyzed 92 patients with S-ALCL from the Peking University Lymphoma Center for clinical and molecular prognostic factors to make clear the role of ALK and other prognostic factors in Han Chinese S-ALCL.

Results: The majority of Chinese S-ALCL patients were young male patients (median age 26, male/female ratio 1.7) and the median age was younger than previous reports regardless of ALK expression status. The only statistically significant different clinical characteristic in S-ALCL between ALK positive (ALK(+)) and ALK negative (ALK(-)) was age, with a younger median age of 22 for ALK+ compared with 30 for ALK-. However, when pediatric patients (<= 18) were excluded, there was no age difference between ALK+ and ALK-. The groups did not differ in the proportion of males, those with clinical stage III/IV (49 vs 51%) or those with extranodal disease (53 vs 59%). Of 73 evaluable patients, the 3-year and 5-year survival rates were 60% and 47%, respectively. Univariate analysis showed that three factors: advanced stage III/IV, lack of expression of ALK, and high Ki-67 expression, were associated with treatment failure in patients with S-ALCL. However, ALK expression correlated with improved survival only in patients younger than 14 years, while not in adult patients. In multivariate analysis, only clinical stage was an independent prognostic factor for survival. Expressions of Wilms tumor 1 (WT1) and B-cell lymphoma 2 protein (BCL-2) correlated with the expression of ALK, but they did not have prognostic significance. High Ki-67 expression was also a poor prognostic factor.

Conclusions: Our results show that ALK expression alone is not sufficient to determine the outcome of ALCL and other prognostic factors must be considered. Clinical stage is an independent prognostic factor. Ki-67 expression is a promising prognostic factor.

语种: 英语
WOS记录号: WOS:000307871100001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53262
Appears in Collections:北京大学第三临床医学院_血液内科_期刊论文

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作者单位: 1.Peking Univ, Hosp 3, Dept Hematol, Beijing 100191, Peoples R China
2.Peking Univ, Hosp 3, Lymphoma Res Ctr, Beijing 100191, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Dept Pathol, Beijing 100191, Peoples R China
4.Beijing Childrens Hosp, Dept Pathol, Beijing 100045, Peoples R China
5.Utah Canc Specialists, Salt Lake City, UT 84106 USA
6.Temple Univ, Sch Med, Dept Pharmacol, Philadelphia, PA 19140 USA

Recommended Citation:
Wang, Yan-Fang,Yang, Yan-Li,Gao, Zi-Fen,et al. Clinical and laboratory characteristics of systemic anaplastic large cell lymphoma in Chinese patients[J]. JOURNAL OF HEMATOLOGY &amp; ONCOLOGY,2012,5.
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