IR@PKUHSC  > 北京大学第三临床医学院  > 眼科
学科主题临床医学
Autologous Transplantation of Retinal Pigment Epithelium-Bruch′s Membrane Complex for Hemorrhagic Age-Related Macular Degeneration
Ma, Zhizhong1; Han, Liang1; Wang, Changguan1; Dou, Hongliang1; Hu, Yuntao1; Feng, Xuefeng1; Xu, Yimin1; Wang, Zhiqiang2; Yin, Zhengqin3; Liu, Yuling1
刊名INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
2009-06-01
DOI10.1167/iovs.08-2573
50期:6页:2975-2981
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Ophthalmology
资助者National Basic Research Program of China ; Peking University Third Hospital ; National Basic Research Program of China ; Peking University Third Hospital
研究领域[WOS]Ophthalmology
关键词[WOS]SUBFOVEAL CHOROIDAL NEOVASCULARIZATION ; RANDOMIZED CLINICAL-TRIAL ; BEAVER DAM EYE ; SUBRETINAL HEMORRHAGE ; PHOTODYNAMIC THERAPY ; OPHTHALMIC FINDINGS ; SUBMACULAR SURGERY ; NATURAL-HISTORY ; FOLLOW-UP ; TRANSLOCATION
英文摘要

PURPOSE. To evaluate a surgical procedure for patients with hemorrhagic age-related macular degeneration (AMD).

METHODS. This procedure consisted of excision of the choroidal neovascular membrane and transplantation of autologous retinal pigment epithelium (RPE)-Bruch′s membrane complex. The RPE-Bruch′s membrane complex for transplantation was surgically developed by dissecting Bruch′s membrane with the choriocapillaris from the medium size choroidal vessel layer at the midperipheral region of the choroid. Twenty-one eyes of 21 patients had this surgical procedure. Visual function tests included best corrected visual acuity (BCVA), multifocal (mf) ERG, and microperimetry. Optical coherence tomography (OCT), fluorescein angiography, and autofluorescence examinations were performed to study the status of the transplanted graft.

RESULTS. Among the 21 eyes, 17 with complete clinical data and qualified follow-up durations, which were 20.35 +/- 10.31 months on average, were analyzed in this series. On the last follow-up visit, the mean for the ETDRS scores increased from 28.65 +/- 23.99 before surgery to 47.76 +/- 17.22 after surgery. Microperimetry showed that after surgery, seven eyes gained central fixation at the 12-month follow-up examination. However, two eyes lost their central fixation on the last follow-up visit. Fourteen (82.35%) of the transplanted patches preserved normal color without depigmentation. Among the 21 eyes, proliferative vitreoretinopathy (PVR) occurred in 3 (14.29%), and a recurrent neovascular membrane was observed in one eye (4.76%).

CONCLUSIONS. The transplantation of the autologous RPE-Bruch′s membrane complex can increase the visual acuity of patients with hemorrhagic AMD. The surviving transplanted graft with functional overlying retina was observed after surgery. (Invest Ophthalmol Vis Sci. 2009; 50: 2975-2981) DOI: 10.1167/iovs.08-2573

语种英语
所属项目编号2007CB512203
资助者National Basic Research Program of China ; Peking University Third Hospital ; National Basic Research Program of China ; Peking University Third Hospital
WOS记录号WOS:000266403800060
Citation statistics
Cited Times:31[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53263
Collection北京大学第三临床医学院_眼科
作者单位1.Peking Univ, Hosp 3, Ctr Eye, Beijing 100083, Peoples R China
2.PLA 254th Hosp, Tianjin, Peoples R China
3.Third Mil Med Univ, SW Eye Hosp, Chongqing, Peoples R China
Recommended Citation
GB/T 7714
Ma, Zhizhong,Han, Liang,Wang, Changguan,et al. Autologous Transplantation of Retinal Pigment Epithelium-Bruch′s Membrane Complex for Hemorrhagic Age-Related Macular Degeneration[J]. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE,2009,50(6):2975-2981.
APA Ma, Zhizhong.,Han, Liang.,Wang, Changguan.,Dou, Hongliang.,Hu, Yuntao.,...&Liu, Yuling.(2009).Autologous Transplantation of Retinal Pigment Epithelium-Bruch′s Membrane Complex for Hemorrhagic Age-Related Macular Degeneration.INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE,50(6),2975-2981.
MLA Ma, Zhizhong,et al."Autologous Transplantation of Retinal Pigment Epithelium-Bruch′s Membrane Complex for Hemorrhagic Age-Related Macular Degeneration".INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 50.6(2009):2975-2981.
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