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学科主题: 基础医学
题名:
Preterm birth-associated neurodevelopmental impairment estimates at regional and global levels for 2010
作者: Blencowe, Hannah1; Lee, Anne C. C.2,3; Cousens, Simon1; Bahalim, Adil4; Narwal, Rajesh1,5; Zhong, Nanbert6,7; Chous, Doris8; Say, Lale8; Modi, Neena9; Katz, Joanne2; Vos, Theo10,11; Marlow, Neil12; Lawn, Joy E.13,14
刊名: PEDIATRIC RESEARCH
发表日期: 2013-12-01
DOI: 10.1038/pr.2013.204
卷: suppl.1, 期:0, 页:17-34
收录类别: SCI ; SSCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pediatrics
研究领域[WOS]: Pediatrics
关键词[WOS]: MIDDLE-INCOME COUNTRIES ; FOR-GESTATIONAL-AGE ; WEIGHT CHILDREN ; FOLLOW-UP ; SYSTEMATIC ANALYSIS ; PSYCHIATRIC-DISORDERS ; DEVELOPMENTAL DELAY ; NEONATAL SURVIVAL ; BEHAVIOR PROBLEMS ; HEALTH OUTCOMES
英文摘要:

BACKGROUND: In 2010, there were an estimated 15 million preterm births worldwide (<37 wk gestation). Survivors are at risk of adverse outcomes, and burden estimation at global and regional levels is critical for priority setting.

METHODS: Systematic reviews and meta-analyses were undertaken to estimate the risk of long-term neurodevelopmental impairment for surviving preterm babies according to the level of care. A compartmental model was used to estimate the number of impaired postneonatal survivors following preterm birth in 2010. A separate model (DisMod-MR) was used to estimate years lived with disability (YLDs) for the global burden of disease 2010 study. Disability adjusted life years (DALYs) were calculated as the sum of YLDs and years of life lost (YLLs).

RESULTS: In 2010, there were an estimated 13 million preterm births who survived beyond the first month. Of these, 345,000 (2.7%, uncertainty range: 269,000-420,000) were estimated to have moderate or severe neurodevelopmental impairment, and a further 567,000 (4.4%, (445,000-732,000)) were estimated to have mild neurodevelopmental impairment. Many more have specific learning or behavioral impairments or reduced physical or mental health. Fewest data are available where the burden is heaviest. Preterm birth was responsible for 77 million DALYs, 3.1% of the global total, of which only 3 million were YLDs.

CONCLUSION: Most preterm births (>90%) survive without neurodevelopmental impairment. Developing effective means of prevention of preterm birth should be a longer term priority, but major burden reduction could be made immediately with improved coverage and quality of care. Improved newborn care would reduce mortality, especially in low-income countries and is likely to reduce impairment in survivors, particularly in middle-income settings.

语种: 英语
项目资助者: Bill and Melinda Gates Foundation through US Fund for UNICEF ; Bill and Melinda Gates Foundation through the Child Health Epidemiology Reference Group ; Bill and Melinda Gates Foundation through Save the Children&prime ; s Saving Newborn Lives program ; Bill and Melinda Gates Foundation ; Department of Reproductive Health and Research, WHO, through the Special Program of Research, Development, and Research Training in Human Reproduction ; USAID ; National Institutes of Health (NIH) ; March of Dimes Global Program ; Westminster Medical School Research Trust, Bliss, UK Department of Health ; Medical Research Cotncil ; National Institute for Health Research ; Westminster Medical School Research Trust ; Bliss, UK Department of Health ; Medical Research Council
WOS记录号: WOS:000331157400003
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53266
Appears in Collections:基础医学院_北京大学医学遗传中心_期刊论文

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作者单位: 1.Inst Hlth Metr & Evaluat, Seattle, WA USA
2.Univ Queensland, Sch Populat Hlth, Herston, Qld, Australia
3.UCL, EGA Inst Womens Hlth, London, England
4.Saving Newborn Lives Save Children, Washington, DC USA
5.WHO, CH-1211 Geneva, Switzerland
6.London Sch Hyg & Trop Med, Fac Epidemiol & Populat Hlth, London WC1, England
7.Brigham & Womens Hosp, Dept Newborn Med, Boston, MA 02115 USA
8.Global Fund Fight AIDS TB & Malaria, Geneva, Switzerland
9.Natl Hlth Syst Resource Ctr, Publ Hlth Planning Div, New Delhi, India
10.Peking Univ, Ctr Med Genet, Beijing 100871, Peoples R China
11.Johns Hopkins Bloomberg Sch Publ Hlth, Dept Int Hlth, Baltimore, MD USA
12.New York State Inst Basic Res Dev Disabil, Staten Isl, NY 10314 USA
13.Univ London Imperial Coll Sci Technol & Med, Sect Neonatal Med, Div Med, London, England
14.London Sch Hyg & Trop Med, Ctr Maternal Reprod & Child Hlth, London WC1, England

Recommended Citation:
Blencowe, Hannah,Lee, Anne C. C.,Cousens, Simon,et al. Preterm birth-associated neurodevelopmental impairment estimates at regional and global levels for 2010[J]. PEDIATRIC RESEARCH,2013,suppl.1(0):17-34.
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