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Toll-like receptor 9 is correlated to disease activity in Chinese systemic lupus erythematosus population
Mu Rong1; Sun Xiao-yun2; Lim, Lik Thai3; Xu Chuan-hui1; Dai Chen-xian1; Su Yin1; Jia Ru-lin1; Li Zhan-guo1
关键词Toll-like Receptor 9 Interferon Regulatory Factor 5 Interferon Alpha Systemic Lupus Erythematosus
刊名CHINESE MEDICAL JOURNAL
2012-08-20
DOI10.3760/cma.j.issn.0366-6999.2012.16.014
125期:16页:2873-2877
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal
资助者Major State Basic Research Development Program of China (973 Program) ; Research and Development Funding of People&prime ; s Hospital, Peking University ; Major State Basic Research Development Program of China (973 Program) ; Research and Development Funding of People&prime ; s Hospital, Peking University
研究领域[WOS]General & Internal Medicine
关键词[WOS]BLOOD MONONUCLEAR-CELLS ; B-CELLS ; AUTOANTIBODY PRODUCTION ; I INTERFERON ; EXPRESSION ; INNATE ; INDUCTION ; TLR9 ; SLE ; SPECIFICITY
英文摘要

Background Toll like receptor (TLR) 9 has been shown to play a crucial role in the pathogenesis of systemic lupus erythematosus (SLE) in animal models. Its pathogenic role in human SLE, however, was poorly elucidated. This study was performed to investigate the role of TLR9 involved in the aberrant signaling pathway and its correlation with disease activity in SLE.

Methods mRNA level of TLR9 and interferon (IFN) regulatory factor 5 (IRF5) in peripheral blood mononuclear cells (PBMCs) were determined by real-time polymerase chain reaction (PCR). IFN-alpha expression was measured in the serum of the SLE patients by enzyme-linked immunosorbent assay (ELISA).

Results TLR9 expression was significantly higher in SLE patients than that in health controls (P=0.011).,SLE patients with positive anti-dsDNA antibody had significantly higher expression of TLR9 than that with negative anti-dsDNA antibody (P=0.001). TLR9 expression was positively correlated with fever (P=0.017), alopecia (P=0.046), safety of estrogens in lupus erythematosus national assessment SLE disease activity index (SELENA-SLEDAI) scare (r(s)=0.385, P=0.003), and the level of IRF5 (r(s)=0.35, P=0.027) and IFN-a (r(s)=0.627, P=0.001) in SLE patients.

Conclusion TLR9 is associated with SLE disease activity and might be involved in the IFN-alpha pathway of SLE. Chin Med J 2012;125(16):2873-2877

语种英语
所属项目编号2012CB517702 ; RDB 2008-23
资助者Major State Basic Research Development Program of China (973 Program) ; Research and Development Funding of People&prime ; s Hospital, Peking University ; Major State Basic Research Development Program of China (973 Program) ; Research and Development Funding of People&prime ; s Hospital, Peking University
WOS记录号WOS:000309378000014
引用统计
被引频次:10[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53268
专题北京大学第三临床医学院_风湿免疫科
作者单位1.Pfizer Investment Co Ltd, Beijing 100010, Peoples R China
2.Gartnavel Royal Hosp, Dept Ophthol, Glasgow, Lanark, Scotland
3.Peking Univ Peoples Hosp, Dept Rheumatol, Beijing 100044, Peoples R China
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GB/T 7714
Mu Rong,Sun Xiao-yun,Lim, Lik Thai,et al. Toll-like receptor 9 is correlated to disease activity in Chinese systemic lupus erythematosus population[J]. CHINESE MEDICAL JOURNAL,2012,125(16):2873-2877.
APA Mu Rong.,Sun Xiao-yun.,Lim, Lik Thai.,Xu Chuan-hui.,Dai Chen-xian.,...&Li Zhan-guo.(2012).Toll-like receptor 9 is correlated to disease activity in Chinese systemic lupus erythematosus population.CHINESE MEDICAL JOURNAL,125(16),2873-2877.
MLA Mu Rong,et al."Toll-like receptor 9 is correlated to disease activity in Chinese systemic lupus erythematosus population".CHINESE MEDICAL JOURNAL 125.16(2012):2873-2877.
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