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Myricetin attenuates hyperinsulinemia-induced insulin resistance in skeletal muscle cells
Ding, Ye; Dai, Xiao-qian; Zhang, Zhao-feng; Li, Yong
关键词Myricetin Hyperinsulinemia Insulin Resistance Amp-activated Protein Kinase Protein Kinase b
刊名EUROPEAN FOOD RESEARCH AND TECHNOLOGY
2012-05-01
DOI10.1007/s00217-012-1701-3
234期:5页:873-881
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Food Science & Technology
资助者Ministry of Science and Technology of PR China ; Ministry of Science and Technology of PR China
研究领域[WOS]Food Science & Technology
关键词[WOS]ACTIVATED PROTEIN-KINASE ; GLUCOSE-TRANSPORT ; ABELMOSCHUS-MOSCHATUS ; C2C12 MYOTUBES ; DIABETIC-RATS ; HEPG2 CELLS ; CONTRACTION ; HOMEOSTASIS ; METABOLISM ; PATHWAYS
英文摘要

Previous studies have shown that hyperinsulinemia is not only a marker of insulin resistance, but also the causative factor of peripheral tissue insulin resistance. It also has been suggested that prolonged high-dose insulin treatment can mimic the effects of hyperinsulinemia and exacerbate insulin resistance in skeletal muscle cells. However, how to prevent or reverse insulin resistance induced by hyperinsulinemia remains largely unclear. In the past few decades, the use of myricetin as an anti-diabetic agent has gained much attention, but little information is available regarding the effects of myricetin on glucose uptake and hyperinsulinemia-induced insulin resistance in skeletal muscle cells. The present study focuses on the effect of myricetin on insulin signaling in skeletal muscle cell line C2C12 myotubes. Initially, the effect of myricetin under normal condition was determined. We found that myricetin′s enhancement in glucose uptake coincided with both protein kinase B (Akt) and AMP-activated protein kinase (AMPK) activities. After that, the role of hyperinsulinemia was investigated. It was showed that prolonged high-dose insulin treatment inhibited both Akt and AMPK activities. As the results, the low-dose insulin stimulation of glucose uptake was inhibited by hyperinsulinemia. However, the treatment of myricetin improved low-dose insulin-stimulated glucose uptake in the hyperinsulinemic state, and this effect essentially depended on the AMPK signal pathway. Together, our data suggest a putative link between hyperinsulinemia and insulin resistance in C2C12 myotubes, and the myricetin treatment stimulates glucose uptake and attenuates insulin resistance.

语种英语
所属项目编号2006BAD27B01
资助者Ministry of Science and Technology of PR China ; Ministry of Science and Technology of PR China
WOS记录号WOS:000302801600015
Citation statistics
Cited Times:7[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53269
Collection北京大学公共卫生学院
作者单位Peking Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, Beijing 100191, Peoples R China
Recommended Citation
GB/T 7714
Ding, Ye,Dai, Xiao-qian,Zhang, Zhao-feng,et al. Myricetin attenuates hyperinsulinemia-induced insulin resistance in skeletal muscle cells[J]. EUROPEAN FOOD RESEARCH AND TECHNOLOGY,2012,234(5):873-881.
APA Ding, Ye,Dai, Xiao-qian,Zhang, Zhao-feng,&Li, Yong.(2012).Myricetin attenuates hyperinsulinemia-induced insulin resistance in skeletal muscle cells.EUROPEAN FOOD RESEARCH AND TECHNOLOGY,234(5),873-881.
MLA Ding, Ye,et al."Myricetin attenuates hyperinsulinemia-induced insulin resistance in skeletal muscle cells".EUROPEAN FOOD RESEARCH AND TECHNOLOGY 234.5(2012):873-881.
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