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学科主题临床医学
Immunohistochemical Profile and Fluorescence In Situ Hybridization Analysis of Diffuse Large B-Cell Lymphoma in Northern China
Li, Ting3; Medeiros, L. Jeffrey1; Lin, Pei1; Yin, Hongfang3; Littlejohn, Martin2; Im, Whan2; Lennon, P. Alan2; Hu, Peter2; Jorgensen, Jeffrey L.1; Liang, Mei1; Guo, Hua3; Yin, C. Cameron1
刊名ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE
2010-05-01
134期:5页:759-765
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medical Laboratory Technology ; Medicine, Research & Experimental ; Pathology
资助者Chinese Scholarship Council ; Chinese Scholarship Council
研究领域[WOS]Medical Laboratory Technology ; Research & Experimental Medicine ; Pathology
关键词[WOS]GERMINAL CENTER PHENOTYPE ; NON-HODGKINS-LYMPHOMAS ; MOLECULAR PATHOGENESIS ; RISK STRATIFICATION ; MALIGNANT-LYMPHOMAS ; DISTINCT SUBGROUPS ; EXPRESSION ; GENE ; BCL-6 ; P63
英文摘要

Context.-Gene expression profiling of diffuse large B-cell lymphoma using complementary DNA microarrays has revealed 2 major prognostic groups in Western countries: germinal center B-cell-like and nongerminal center B-cell-like lymphomas. Immunohistochemical analysis using antibodies specific for CD10, BCL6, and MUM1 has been proposed as a surrogate for gene expression profiling.

Objective.-To study the immunohistochemical features of diffuse large B-cell lymphoma cases from northern China because geographic differences for this disease are known to exist.

Design.-Morphologic, immunohistochemical, and fluorescence in situ hybridization analyses of 63 cases of diffuse large B-cell lymphoma from northern China.

Results.-There were 38 men and 25 women with a median age of 57 years (range, 12-87 years). CD10 was positive in 19 cases (30%), BCL6 was positive in 22 cases (35%), and MUM1 was positive in 32 cases (51%). Twenty-one (33%) cases were germinal center B-cell-like lymphoma, and 42 (67%) were nongerminal center B-cell-like lymphoma. BCL2 was expressed more often in nongerminal center B-cell-like disease versus germinal center B-cell-like disease (60% versus 24%, P = .01) and in nodal versus extranodal (64% versus 30%, P = .01) cases. Fluorescence in situ hybridization analysis showed BCL6, MYC, and BCL2 rearrangements in 11 of 32 (34%), 8 of 27 (30%), and 11 of 50 (22%) cases, respectively.

Conclusions.-These results add to what is known about the geographic variation of diffuse large B-cell lymphomas. In northern China, the frequency of the germinal center B-cell- like type and BCL6 expression and/or BCL6 rearrangement is less and the frequency of MYC rearrangement is greater than have been reported in Western countries. (Arch Pathol Lab Med. 2010;134:759-765)

语种英语
资助者Chinese Scholarship Council ; Chinese Scholarship Council
WOS记录号WOS:000277320200013
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53278
专题北京大学第一临床医学院_病理科
作者单位1.Univ Texas MD Anderson Canc Ctr, Dept Hematopathol, Unit 72, Houston, TX 77030 USA
2.Univ Texas MD Anderson Canc Ctr, Mol Genet Technol Program, Houston, TX 77030 USA
3.Peking Univ, Hosp 1, Dept Pathol, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Li, Ting,Medeiros, L. Jeffrey,Lin, Pei,et al. Immunohistochemical Profile and Fluorescence In Situ Hybridization Analysis of Diffuse Large B-Cell Lymphoma in Northern China[J]. ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE,2010,134(5):759-765.
APA Li, Ting.,Medeiros, L. Jeffrey.,Lin, Pei.,Yin, Hongfang.,Littlejohn, Martin.,...&Yin, C. Cameron.(2010).Immunohistochemical Profile and Fluorescence In Situ Hybridization Analysis of Diffuse Large B-Cell Lymphoma in Northern China.ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE,134(5),759-765.
MLA Li, Ting,et al."Immunohistochemical Profile and Fluorescence In Situ Hybridization Analysis of Diffuse Large B-Cell Lymphoma in Northern China".ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE 134.5(2010):759-765.
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