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学科主题临床医学
Effect of L-carnitine and/or L-acetyl-carnitine in nutrition treatment for male infertility: a systematic review
Zhou, Xin()1; Liu, Fang()1; Zhai, Suodi()1
关键词Food Aid Expert System Disaster Relief Monitoring Evaluation Male Infertility Carnitine Pregnancy Rate Sperm Motility Systematic Review
刊名ASIA PACIFIC JOURNAL OF CLINICAL NUTRITION
2007
suppl.1页:383-390
收录类别ISTP ; SCI
文章类型Proceedings Paper
WOS标题词Science & Technology
类目[WOS]Nutrition & Dietetics
研究领域[WOS]Nutrition & Dietetics
关键词[WOS]BLIND RANDOMIZED-TRIAL ; QUALITY ; MEN ; ASTHENOZOOSPERMIA ; SPERMATOZOA ; METABOLISM
英文摘要

The aim of this systematic review was to quantify the efficacy of L-carnitine (LC) and/or L-acetyl-carnitine (LAC) in nutrition treatment for male infertility according to present clinical evidence. Biomedical databases were searched to collect related clinical trials and nine relevant randomized controlled trials (RCTs) were included. The quality of the RCTs was assessed based on their performance in randomization, blinding, and allocation concealment. The meta-analysis compared LC and /or LAC therapy to placebo treatment found significant improvement in pregnancy rate (OR = 4.10, 95% CI (2.08, 8.08), p < 0.0001), total sperm motility (WMD = 7.43, 95% Cl (1.72, 13.14), p = 0.04, forward sperm motility (WMD = 11.83, 95% Cl (0.49, 23.16), p = 0.04) and atypical sperm cell (WMD = -5.72, 95% Cl (-7.89, -3.56), p < 0.00001). However, no significant difference was found in the sperm concentration (WMD = 5.69, 95% CI (4.47, 15.84), p = 0.27) and semen volume (WMD = 0.28, 95% Cl (-0.02, 0.58), p = 0.07). In conclusion, the administration of LC and/or LAC may be effective in improving pregnancy rate and sperm kinetic features in patients affected by male infertility. However, the exact efficacy of carnitines on male infertility needs to be confirmed by further investigations.

语种英语
WOS记录号WOS:000245926500070
引用统计
被引频次:47[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53279
专题北京大学第三临床医学院_药剂科
北京大学第三临床医学院_口腔科
作者单位1.Peking Univ, Hosp 3, Dept Pharm, Beijing 100083, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, Dept Pharm Adm & Clin Pharm, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Zhou, Xin,Liu, Fang,Zhai, Suodi. Effect of L-carnitine and/or L-acetyl-carnitine in nutrition treatment for male infertility: a systematic review[J]. ASIA PACIFIC JOURNAL OF CLINICAL NUTRITION,2007,suppl.1:383-390.
APA Zhou, Xin,Liu, Fang,&Zhai, Suodi.(2007).Effect of L-carnitine and/or L-acetyl-carnitine in nutrition treatment for male infertility: a systematic review.ASIA PACIFIC JOURNAL OF CLINICAL NUTRITION,suppl.1,383-390.
MLA Zhou, Xin,et al."Effect of L-carnitine and/or L-acetyl-carnitine in nutrition treatment for male infertility: a systematic review".ASIA PACIFIC JOURNAL OF CLINICAL NUTRITION suppl.1(2007):383-390.
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