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学科主题: 临床医学
题名:
Effect of L-carnitine and/or L-acetyl-carnitine in nutrition treatment for male infertility: a systematic review
作者: Zhou, Xin1; Liu, Fang1; Zhai, Suodi1
关键词: food aid ; expert system ; disaster relief ; monitoring ; evaluation male infertility ; carnitine ; pregnancy rate ; sperm motility ; systematic review
刊名: ASIA PACIFIC JOURNAL OF CLINICAL NUTRITION
发表日期: 2007
卷: suppl.1, 页:383-390
收录类别: ISTP ; SCI
文章类型: Proceedings Paper
WOS标题词: Science & Technology
类目[WOS]: Nutrition & Dietetics
研究领域[WOS]: Nutrition & Dietetics
关键词[WOS]: BLIND RANDOMIZED-TRIAL ; QUALITY ; MEN ; ASTHENOZOOSPERMIA ; SPERMATOZOA ; METABOLISM
英文摘要:

The aim of this systematic review was to quantify the efficacy of L-carnitine (LC) and/or L-acetyl-carnitine (LAC) in nutrition treatment for male infertility according to present clinical evidence. Biomedical databases were searched to collect related clinical trials and nine relevant randomized controlled trials (RCTs) were included. The quality of the RCTs was assessed based on their performance in randomization, blinding, and allocation concealment. The meta-analysis compared LC and /or LAC therapy to placebo treatment found significant improvement in pregnancy rate (OR = 4.10, 95% CI (2.08, 8.08), p < 0.0001), total sperm motility (WMD = 7.43, 95% Cl (1.72, 13.14), p = 0.04, forward sperm motility (WMD = 11.83, 95% Cl (0.49, 23.16), p = 0.04) and atypical sperm cell (WMD = -5.72, 95% Cl (-7.89, -3.56), p < 0.00001). However, no significant difference was found in the sperm concentration (WMD = 5.69, 95% CI (4.47, 15.84), p = 0.27) and semen volume (WMD = 0.28, 95% Cl (-0.02, 0.58), p = 0.07). In conclusion, the administration of LC and/or LAC may be effective in improving pregnancy rate and sperm kinetic features in patients affected by male infertility. However, the exact efficacy of carnitines on male infertility needs to be confirmed by further investigations.

语种: 英语
WOS记录号: WOS:000245926500070
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53279
Appears in Collections:北京大学第三临床医学院_药剂科_期刊论文

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作者单位: 1.Peking Univ, Hosp 3, Dept Pharm, Beijing 100083, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, Dept Pharm Adm & Clin Pharm, Beijing 100083, Peoples R China

Recommended Citation:
Zhou, Xin,Liu, Fang,Zhai, Suodi. Effect of L-carnitine and/or L-acetyl-carnitine in nutrition treatment for male infertility: a systematic review[J]. ASIA PACIFIC JOURNAL OF CLINICAL NUTRITION,2007,suppl.1:383-390.
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