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学科主题: 临床医学
题名:
Intermedin1-53 activates L-arginine/nitric oxide synthase/nitric oxide pathway in rat aortas
作者: Yang, JHU1; Pan, CS1; Jia, YX1; Zhang, J1; Zhao, J1; Pang, YZ1; Yang, J1; Tang, CS1; Qi, YF1
关键词: intermedin ; adrenomedullin ; nitric oxide ; L-Arginine
刊名: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
发表日期: 2006-03-10
DOI: 10.1016/j.bbrc.2006.01.010
卷: 341, 期:2, 页:567-572
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]: Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]: SMOOTH-MUSCLE-CELLS ; PHOSPHATIDYLINOSITOL 3-KINASE/AKT-DEPENDENT PATHWAY ; NITRIC-OXIDE ; AMINO-ACID ; GENE-EXPRESSION ; ISCHEMIA/REPERFUSION INJURY ; ADRENOMEDULLIN GENE ; HEART-FAILURE ; TRANSPORTER ; CAT-1
英文摘要:

Intermedin (IMD), a novel member of the calcitonin/calcitonin gene-related peptide (CGRP) family, has similar or more potent vasodilatory and hypotensive actions than adrenomedulin (ADM) and CGRP. The present study was designed to observe the effects of synthetic rat IMD1-53 on L-arginine (L-Arg) cellular transport, nitric oxide synthase (NOS) activity, and nitric oxide (NO) production in the isolated rat aortic ring to illustrate its direct effect oil the L-Arg/NOS/NO pathway in vasculature. IMD1-53 significantly increased NO production and cNOS activity in rat aortas and was more potent than equivalent ADM. But the peptides of both IMD and ADM had no effect oil inducible NOS expression and activity. Otherwise, IMD1-53 induced a concentration-dependent increase ill [3 H]L-Arg transport and its effect was more potent than that of all equivalent concentration of ADM. Semiquantitative RT-PCR revealed that IMD1-53 significantly increased cationic amino acid transport (CAT)-1 and CAT-2B mRNA expression, and its effect was similar to that of ADM. All these results suggest that IMD1-53 might regulate vessel function homeostasis Via upregulating the L-Arg/NOS/ NO pathway. (c) 2006 Elsevier Inc. All rights reserved.

语种: 英语
WOS记录号: WOS:000235414400041
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53280
Appears in Collections:北京大学第一临床医学院_心血管内科_期刊论文

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作者单位: 1.Minist Educ, Key Lab Mol Cardiovasc Sci, Beijing 100083, Peoples R China
2.Phoenix Pharmaceut Inc, Belmont, CA 94002 USA
3.Peking Univ, Hosp 1, Cardiovasc Res Inst, Beijing 100034, Peoples R China
4.Peking Univ, Hlth Sci Ctr, Dept Physiol & Pathophysiol, Beijing 100083, Peoples R China

Recommended Citation:
Yang, JHU,Pan, CS,Jia, YX,et al. Intermedin1-53 activates L-arginine/nitric oxide synthase/nitric oxide pathway in rat aortas[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2006,341(2):567-572.
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