北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第一临床医学院  > 老年病内科  > 期刊论文
学科主题: 临床医学
题名:
Association Between High-density Lipoprotein Cholesterol and Renal Function in Elderly Hypertension A Cross-sectional Study in Chinese Population
作者: Zhang, Ya-Ping1; Lu, Ming-Gen3; Duan, Dayue Darrel4; Liu, Ying-Long1; Liu, Meilin5; Li, Ying6; Kuang, Ze-Min2; Lu, Yao6; Liu, Xing6; Li, Xiao-Hui7; Yuan, Hong6
刊名: MEDICINE
发表日期: 2015-04-01
DOI: 10.1097/MD.0000000000000651
卷: 94, 期:14
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: CHRONIC KIDNEY-DISEASE ; GLOMERULAR-FILTRATION-RATE ; IMPAIRED FASTING GLUCOSE ; TOTAL SERUM-CHOLESTEROL ; CARDIOVASCULAR OUTCOMES ; LIPID-METABOLISM ; BLOOD-PRESSURE ; HYPERFILTRATION ; RISK ; MECHANISMS
英文摘要:

Few studies have yet investigated the possible association between high-density lipoprotein cholesterol (HDL-C) and kidney function in elderly patients with primary hypertension. Accordingly, the aim of the present study was to evaluate the relationship between HDL-C and kidney function in elderly hypertension.

A total of 14,644 elderly hypertensive subjects were enrolled in our cross-sectional study. The patients were categorized based on serum HDL-C level and glomerular filtration rate (GFR) value, respectively. One-way analysis of variance was used to compare the parameters among different groups. Bonferroni correction was performed for multiple comparisons. Analysis of covariance was used to control for confounding factors. The significance of difference between 3 groups and more was determined by chi-square test for categorical variables.

Serum creatinine and uric acid were negatively related to HDL-C level, whereas GFR was positively related to HDL-C level in elderly hypertensive patients according to tertiles of HDL-C and tertiles of HDLC/total cholesterol ratio (all P for trends < 0.05). The male elderly hypertensive patients showed stronger relationship between HDL-C and renal function than the female elderly hypertensive subjects. Low HDL-C was associated with renal insufficiency and proteinuria in the hypertensive elderly (P< 0.05). The elderly "renal-hyperfiltrator′′ appeared to have lower HDL-C level, compared with the `` normal renal-filtrator′′ (P< 0.05). There was an inverse "V′′ shape between HDL-C and GFR by GFR strata.

Our results point out that there is an association of low HDL-C level with impaired kidney function in elderly hypertensive patients. Glomerular hyperfiltration may also affect HDL-C level and sex might be an influential factor for the association of HDL-C with kidney function in elderly hypertension.

语种: 英语
所属项目编号: 81273594 ; 81470535 ; 81371443 ; 2012ZX09303014001 ; 2012BAI37B05 ; 7152045
项目资助者: National Natural Science Foundation of China ; National Science and Technology Major Projects for "Major New Drugs Innovation and Development" ; National Key Technology RD Program ; Beijing Natural Science Foundation
WOS记录号: WOS:000352789400009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53281
Appears in Collections:北京大学第一临床医学院_老年病内科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Capital Med Univ, Beijing Anzhen Hosp, Pediat Heart Ctr, Beijing, Peoples R China
2.Capital Med Univ, Beijing Anzhen Hosp, Dept Hypertens, Beijing, Peoples R China
3.Univ Nevada, Sch Med, Sch Community & Hlth Sci, Reno, NV 89557 USA
4.Univ Nevada, Sch Med, Lab Cardiovasc Phen, Dept Pharmacol, Reno, NV 89557 USA
5.Peking Univ, Hosp 1, Dept Geriatr, Beijing 100871, Peoples R China
6.Cent S Univ, Xiang Ya Hosp 3, Ctr Clin Pharmacol, Changsha 410013, Hunan, Peoples R China
7.Cent S Univ, Dept Pharmacol, Sch Pharmaceut Sci, Changsha 410013, Hunan, Peoples R China

Recommended Citation:
Zhang, Ya-Ping,Lu, Ming-Gen,Duan, Dayue Darrel,et al. Association Between High-density Lipoprotein Cholesterol and Renal Function in Elderly Hypertension A Cross-sectional Study in Chinese Population[J]. MEDICINE,2015,94(14).
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Zhang, Ya-Ping]'s Articles
[Lu, Ming-Gen]'s Articles
[Duan, Dayue Darrel]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Zhang, Ya-Ping]‘s Articles
[Lu, Ming-Gen]‘s Articles
[Duan, Dayue Darrel]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace