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学科主题临床医学
Altered Fecal Microbiota Composition Associated with Food Allergy in Infants
Ling, Zongxin1,2; Li, Zailing3; Liu, Xia2,4; Cheng, Yiwen1,2; Luo, Yueqiu1,2; Tong, Xiaojuan1,2; Yuan, Li1,2; Wang, Yuezhu5; Sun, Jinbo3; Li, Lanjuan1,2; Xiang, Charlie1,2,6
刊名APPLIED AND ENVIRONMENTAL MICROBIOLOGY
2014-04-01
DOI10.1128/AEM.00003-14
80期:8页:2546-2554
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biotechnology & Applied Microbiology ; Microbiology
研究领域[WOS]Biotechnology & Applied Microbiology ; Microbiology
关键词[WOS]GUT MICROBIOTA ; IMMUNE-SYSTEM ; ATOPIC ECZEMA ; INTESTINAL MICROBIOTA ; REDUCED DIVERSITY ; YOUNG-PEOPLE ; INDUCTION ; COMMUNITY ; CHILDREN ; DIAGNOSIS
英文摘要

Increasing evidence suggests that perturbations in the intestinal microbiota composition of infants are implicated in the pathogenesis of food allergy (FA), while the actual structure and composition of the intestinal microbiota in human beings with FA remain unclear. Microbial diversity and composition were analyzed with parallel barcoded 454 pyrosequencing targeting the 16S rRNA gene hypervariable V1-V3 regions in the feces of 34 infants with FA (17 IgE mediated and 17 non-IgE mediated) and 45 healthy controls. Here, we showed that several key FA-associated bacterial phylotypes, but not the overall microbiota diversity, significantly changed in infancy fecal microbiota with FA and were associated with the development of FA. The proportion of abundant Bacteroidetes, Proteobacteria, and Actinobacteria phyla were significantly reduced, while the Firmicutes phylum was highly enriched in the FA group (P<0.05). Abundant Clostridiaceae 1 organisms were prevalent in infants with FA at the family level (P = 0.016). FA-enriched phylotypes negatively correlated with interleukin-10, for example, the genera Enterococcus and Staphylococcus. Despite profound interindividual variability, levels of 20 predominant genera were significantly different between the FA and healthy control groups (P<0.05). Infants with IgE-mediated FA had increased levels of Clostridium sensu stricto and Anaerobacter and decreased levels of Bacteroides and Clostridium XVIII (P<0.05). A positive correlation was observed between Clostridium sensu stricto and serum-specific IgE (R = 0.655, P < 0.001). The specific microbiota signature could distinguish infants with IgE-mediated FA from non-IgE-mediated ones. Detailed microbiota analysis of a well-characterized cohort of infants with FA showed that dysbiosis of fecal microbiota with several FA-associated key phylotypes may play a pathogenic role in FA.

语种英语
WOS记录号WOS:000333531600024
项目编号2013CB531404
资助机构National Basic Research Program of China (973 Program)
引用统计
被引频次:82[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53282
专题北京大学第三临床医学院_儿科
作者单位1.Zhejiang Univ, Sch Med, Affiliated Hosp 1, State Key Lab Diag & Treatment Infect Dis, Hangzhou 310003, Zhejiang, Peoples R China
2.Collaborat Innovat Ctr Diag & Treatment Infect Di, Hangzhou, Zhejiang, Peoples R China
3.Peking Univ, Hosp 3, Dept Pediat, Beijing 100871, Peoples R China
4.Zhejiang Univ, Sch Med, Affiliated Hosp 1, Dept Intens Care Unit, Hangzhou 310003, Zhejiang, Peoples R China
5.Chinese Natl Human Genome Ctr Shanghai, Shanghai, Peoples R China
6.J Craig Venter Inst, Rockville, MD USA
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GB/T 7714
Ling, Zongxin,Li, Zailing,Liu, Xia,et al. Altered Fecal Microbiota Composition Associated with Food Allergy in Infants[J]. APPLIED AND ENVIRONMENTAL MICROBIOLOGY,2014,80(8):2546-2554.
APA Ling, Zongxin.,Li, Zailing.,Liu, Xia.,Cheng, Yiwen.,Luo, Yueqiu.,...&Xiang, Charlie.(2014).Altered Fecal Microbiota Composition Associated with Food Allergy in Infants.APPLIED AND ENVIRONMENTAL MICROBIOLOGY,80(8),2546-2554.
MLA Ling, Zongxin,et al."Altered Fecal Microbiota Composition Associated with Food Allergy in Infants".APPLIED AND ENVIRONMENTAL MICROBIOLOGY 80.8(2014):2546-2554.
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