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学科主题: 药学
题名:
Synthesis and preliminary biological evaluation of the derivatives of O-6-benzylguanine as inactivators of O-6-alkylguanine-DNA alkyltransferase
作者: Zhang, Lei2,3; Jia, Bing1; Hu, Chang Feng2; Wang, Fan1; Cui, Yu Xin2,3
关键词: O-6-BG derivatives ; AGT inactivator
刊名: CHINESE CHEMICAL LETTERS
发表日期: 2008-07-01
DOI: 10.1016/j.cclet.2008.04.046
卷: 19, 期:7, 页:801-804
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Multidisciplinary
研究领域[WOS]: Chemistry
关键词[WOS]: MELANOMA XENOGRAFT MODEL ; O-6-(4-BROMOTHENYL)GUANINE ; PROTEIN ; AGENTS
英文摘要:

A series of new O-6-BG derivatives (14-21,23-30) were synthesized as inactivators of O-6-Alkylguanine-DNA alkyltransferase (AGT), and their ability to inhibit AGT was preliminary evaluated by MTT with O-6-BG as the control. The result suggested compound 30 displayed a higher activity than O-6-BG. (C) 2008 Yu Xin Cui. Published by Elsevier B. V. on behalf of Chinese Chemical Society. All rights reserved.

语种: 英语
WOS记录号: WOS:000263668700012
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53283
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, Med Isotope Res Ctr, Beijing 100083, Peoples R China
2.Peking Univ, State Key Lab Nat & Biomimet Drugs, Sch Pharmaceut Sci, Beijing 100083, Peoples R China
3.Peking Univ, Med & Healthy Anal Ctr, Beijing 100083, Peoples R China

Recommended Citation:
Zhang, Lei,Jia, Bing,Hu, Chang Feng,et al. Synthesis and preliminary biological evaluation of the derivatives of O-6-benzylguanine as inactivators of O-6-alkylguanine-DNA alkyltransferase[J]. CHINESE CHEMICAL LETTERS,2008,19(7):801-804.
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