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Synthesis and preliminary biological evaluation of the derivatives of O-6-benzylguanine as inactivators of O-6-alkylguanine-DNA alkyltransferase
Zhang, Lei2,3; Jia, Bing1; Hu, Chang Feng2; Wang, Fan1; Cui, Yu Xin2,3
关键词O-6-bg Derivatives Agt Inactivator
刊名CHINESE CHEMICAL LETTERS
2008-07-01
DOI10.1016/j.cclet.2008.04.046
19期:7页:801-804
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Multidisciplinary
研究领域[WOS]Chemistry
关键词[WOS]MELANOMA XENOGRAFT MODEL ; O-6-(4-BROMOTHENYL)GUANINE ; PROTEIN ; AGENTS
英文摘要

A series of new O-6-BG derivatives (14-21,23-30) were synthesized as inactivators of O-6-Alkylguanine-DNA alkyltransferase (AGT), and their ability to inhibit AGT was preliminary evaluated by MTT with O-6-BG as the control. The result suggested compound 30 displayed a higher activity than O-6-BG. (C) 2008 Yu Xin Cui. Published by Elsevier B. V. on behalf of Chinese Chemical Society. All rights reserved.

语种英语
WOS记录号WOS:000263668700012
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53283
专题北京大学药学院
北京大学基础医学院
作者单位1.Peking Univ, Med Isotope Res Ctr, Beijing 100083, Peoples R China
2.Peking Univ, State Key Lab Nat & Biomimet Drugs, Sch Pharmaceut Sci, Beijing 100083, Peoples R China
3.Peking Univ, Med & Healthy Anal Ctr, Beijing 100083, Peoples R China
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Zhang, Lei,Jia, Bing,Hu, Chang Feng,et al. Synthesis and preliminary biological evaluation of the derivatives of O-6-benzylguanine as inactivators of O-6-alkylguanine-DNA alkyltransferase[J]. CHINESE CHEMICAL LETTERS,2008,19(7):801-804.
APA Zhang, Lei,Jia, Bing,Hu, Chang Feng,Wang, Fan,&Cui, Yu Xin.(2008).Synthesis and preliminary biological evaluation of the derivatives of O-6-benzylguanine as inactivators of O-6-alkylguanine-DNA alkyltransferase.CHINESE CHEMICAL LETTERS,19(7),801-804.
MLA Zhang, Lei,et al."Synthesis and preliminary biological evaluation of the derivatives of O-6-benzylguanine as inactivators of O-6-alkylguanine-DNA alkyltransferase".CHINESE CHEMICAL LETTERS 19.7(2008):801-804.
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