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学科主题: 药学
题名:
Quinolone alkaloids with antibacterial and cytotoxic activities from the fruits of Evodia rutaecarpa
作者: Wang, Xiao-Xia1,2; Zan, Ke2; Shi, She-Po3; Zeng, Ke-Wu2; Jiang, Yong2; Guan, Yan4,5; Xiao, Chun-Ling4,5; Gao, Hui-Yuan1; Wu, Li-Jun1; Tu, Peng-Fei1,2,3
关键词: Evodia rutaecarpa ; Quinolone alkaloids ; Antibacterial activity ; Cytotoxic activity
刊名: FITOTERAPIA
发表日期: 2013-09-01
DOI: 10.1016/j.fitote.2013.04.007
卷: 89, 页:1-7
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
英文摘要:

Five new quinolone alkaloids, euocarpines A-E (16-20), four new natural products (1, 4, 12, and 14), and eleven known natural products were isolated from the fruits of Evodia rutaecarpa (Juss.) Benth. The structures of the new compounds were elucidated based on spectroscopic evidence. All compounds were evaluated for their antibacterial activity against three strains and for their cytotoxic activity against four human tumor cell lines. The results revealed that 5, 7-11, 13, 14, and 16-20 exhibited moderate antibacterial activities (MIC values: 4-128 mu g/mL), and 9, 11, 14, and 17 exhibited moderate cytotoxic activities against HepG-2, Hela, BEL7402, and BEL7403 (IC50 values: 15.85-56.36 mu M). Crown Copyright (c) 2013 Published by Elsevier B.V. All rights reserved.

语种: 英语
所属项目编号: 2011ZX09201-201-9 ; 2012ZX09301002-002-002 ; 2012ZX09304-005
项目资助者: National Key Technology R &amp ; D Program "New Drug Innovation" of China
WOS记录号: WOS:000323856500001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53285
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Shenyang Pharmaceut Univ, Sch Tradit Chinese Mat Med, Shenyang 110016, Peoples R China
2.Peking Univ, Hlth Sci Ctr, State Key Lab Nat & Biomimet Drugs, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
3.Beijing Univ Chinese Med, Modern Res Ctr Tradit Chinese Med, Beijing 100029, Peoples R China
4.Acad Med Sci, Inst Med Biotechnol, Beijing 100050, Peoples R China
5.Peking Union Med Coll, Beijing 100050, Peoples R China

Recommended Citation:
Wang, Xiao-Xia,Zan, Ke,Shi, She-Po,et al. Quinolone alkaloids with antibacterial and cytotoxic activities from the fruits of Evodia rutaecarpa[J]. FITOTERAPIA,2013,89:1-7.
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