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Quinolone alkaloids with antibacterial and cytotoxic activities from the fruits of Evodia rutaecarpa
Wang, Xiao-Xia1,2; Zan, Ke2; Shi, She-Po3; Zeng, Ke-Wu2; Jiang, Yong2; Guan, Yan4,5; Xiao, Chun-Ling4,5; Gao, Hui-Yuan1; Wu, Li-Jun1; Tu, Peng-Fei1,2,3
关键词Evodia Rutaecarpa Quinolone Alkaloids Antibacterial Activity Cytotoxic Activity
刊名FITOTERAPIA
2013-09-01
DOI10.1016/j.fitote.2013.04.007
89页:1-7
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]Pharmacology & Pharmacy
英文摘要

Five new quinolone alkaloids, euocarpines A-E (16-20), four new natural products (1, 4, 12, and 14), and eleven known natural products were isolated from the fruits of Evodia rutaecarpa (Juss.) Benth. The structures of the new compounds were elucidated based on spectroscopic evidence. All compounds were evaluated for their antibacterial activity against three strains and for their cytotoxic activity against four human tumor cell lines. The results revealed that 5, 7-11, 13, 14, and 16-20 exhibited moderate antibacterial activities (MIC values: 4-128 mu g/mL), and 9, 11, 14, and 17 exhibited moderate cytotoxic activities against HepG-2, Hela, BEL7402, and BEL7403 (IC50 values: 15.85-56.36 mu M). Crown Copyright (c) 2013 Published by Elsevier B.V. All rights reserved.

语种英语
WOS记录号WOS:000323856500001
项目编号2011ZX09201-201-9 ; 2012ZX09301002-002-002 ; 2012ZX09304-005
资助机构National Key Technology R &amp ; D Program "New Drug Innovation" of China
引用统计
被引频次:15[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53285
专题北京大学药学院
北京大学药学院_天然药物学系
作者单位1.Shenyang Pharmaceut Univ, Sch Tradit Chinese Mat Med, Shenyang 110016, Peoples R China
2.Peking Univ, Hlth Sci Ctr, State Key Lab Nat & Biomimet Drugs, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
3.Beijing Univ Chinese Med, Modern Res Ctr Tradit Chinese Med, Beijing 100029, Peoples R China
4.Acad Med Sci, Inst Med Biotechnol, Beijing 100050, Peoples R China
5.Peking Union Med Coll, Beijing 100050, Peoples R China
推荐引用方式
GB/T 7714
Wang, Xiao-Xia,Zan, Ke,Shi, She-Po,et al. Quinolone alkaloids with antibacterial and cytotoxic activities from the fruits of Evodia rutaecarpa[J]. FITOTERAPIA,2013,89:1-7.
APA Wang, Xiao-Xia.,Zan, Ke.,Shi, She-Po.,Zeng, Ke-Wu.,Jiang, Yong.,...&Tu, Peng-Fei.(2013).Quinolone alkaloids with antibacterial and cytotoxic activities from the fruits of Evodia rutaecarpa.FITOTERAPIA,89,1-7.
MLA Wang, Xiao-Xia,et al."Quinolone alkaloids with antibacterial and cytotoxic activities from the fruits of Evodia rutaecarpa".FITOTERAPIA 89(2013):1-7.
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