IR@PKUHSC  > 北京大学公共卫生学院
学科主题公共卫生
Isoflavone and its metabolite equol inhibit the development of 7,12-dimethylbenz(a)anthracene (DMBA)-induced mammary tumours in ovariectomised rats
Ma, Defu1; Zhang, Yumei2; Xue, Yong2; Wang, Peiyu1; Yang, Titi2; Shao, Xianglong2
关键词Isoflavones Mammary Tumours Equol Oestrogen Receptor Dmba
刊名JOURNAL OF FUNCTIONAL FOODS
2014-03-01
DOI10.1016/j.jff.2013.12.027
7页:580-589
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Food Science & Technology
研究领域[WOS]Food Science & Technology
关键词[WOS]BREAST-CANCER RISK ; CELLS IN-VITRO ; SOY INTAKE ; PHYSIOLOGICAL CONCENTRATIONS ; ENDOTHELIAL-CELLS ; RECEPTOR-BETA ; GROWTH ; PHYTOESTROGENS ; ANTIOXIDANT ; GENISTEIN
英文摘要

Studies have yet to determine whether or not equol can explain the chemopreventive effect of soy. In the present study, a single oral dose of 5 mg 7,12-dimethylbenz(a)anthracene (DMBA) was administered to 120 rats. After ovariectomy, these rats were divided into eight different treatment groups: control group (CG); high isoflavone (HI); middle isoflavone (MI); low isoflavone (Li); high equol (HE); middle equol (ME); low equol (LE); and oestrogen group (EG). At week 24 after DMBA was administered, tumour incidences were 60% (9/15) in CG, 13.3% (2/15) in the MI group, 13.3% (2/15) in the Li group, 6.7% (1/15) in the LE group, and 73.3% (11/15) in EG. Isoflavone/equol groups exhibited significantly lower incidences of tumour and longer mean latent period compared with CG and EG. Thiobarbituric acid reactive substances were significantly decreased in the plasma of the rats in HI and MI groups as well as in equol treatment groups compared with CG. Moreover, RT-PCR and western blotting show that the mRNA and protein expression levels of ER alpha and ER beta were significantly higher in isoflavone/equol treatment groups than in CG. In conclusion, isoflavone/equol intake can significantly inhibit the development of post-menopausal mammary tumours by antioxidant activities and oestrogenic activities. (C) 2014 Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000335203500059
项目编号81172653 ; 30872115 ; 30872114 ; 81202193 ; 7122103
资助机构National Natural Science Foundation of China ; Beijing Natural Science Foundation
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53293
专题北京大学公共卫生学院
北京大学药学院_药剂学系
北京大学公共卫生学院_营养与食品卫生学系
北京大学公共卫生学院_公共卫生学院
作者单位1.Peking Univ, Hlth Sci Ctr, Sch Publ Hlth, Dept Social Med & Hlth Educ, Beijing 100191, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Sch Publ Hlth, Dept Nutr & Food Hyg, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Ma, Defu,Zhang, Yumei,Xue, Yong,et al. Isoflavone and its metabolite equol inhibit the development of 7,12-dimethylbenz(a)anthracene (DMBA)-induced mammary tumours in ovariectomised rats[J]. JOURNAL OF FUNCTIONAL FOODS,2014,7:580-589.
APA Ma, Defu,Zhang, Yumei,Xue, Yong,Wang, Peiyu,Yang, Titi,&Shao, Xianglong.(2014).Isoflavone and its metabolite equol inhibit the development of 7,12-dimethylbenz(a)anthracene (DMBA)-induced mammary tumours in ovariectomised rats.JOURNAL OF FUNCTIONAL FOODS,7,580-589.
MLA Ma, Defu,et al."Isoflavone and its metabolite equol inhibit the development of 7,12-dimethylbenz(a)anthracene (DMBA)-induced mammary tumours in ovariectomised rats".JOURNAL OF FUNCTIONAL FOODS 7(2014):580-589.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Ma, Defu]的文章
[Zhang, Yumei]的文章
[Xue, Yong]的文章
百度学术
百度学术中相似的文章
[Ma, Defu]的文章
[Zhang, Yumei]的文章
[Xue, Yong]的文章
必应学术
必应学术中相似的文章
[Ma, Defu]的文章
[Zhang, Yumei]的文章
[Xue, Yong]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。