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学科主题: 公共卫生
题名:
Isoflavone and its metabolite equol inhibit the development of 7,12-dimethylbenz(a)anthracene (DMBA)-induced mammary tumours in ovariectomised rats
作者: Ma, Defu1; Zhang, Yumei2; Xue, Yong2; Wang, Peiyu1; Yang, Titi2; Shao, Xianglong2
关键词: Isoflavones ; Mammary tumours ; Equol ; Oestrogen receptor ; DMBA
刊名: JOURNAL OF FUNCTIONAL FOODS
发表日期: 2014-03-01
DOI: 10.1016/j.jff.2013.12.027
卷: 7, 页:580-589
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Food Science & Technology
研究领域[WOS]: Food Science & Technology
关键词[WOS]: BREAST-CANCER RISK ; CELLS IN-VITRO ; SOY INTAKE ; PHYSIOLOGICAL CONCENTRATIONS ; ENDOTHELIAL-CELLS ; RECEPTOR-BETA ; GROWTH ; PHYTOESTROGENS ; ANTIOXIDANT ; GENISTEIN
英文摘要:

Studies have yet to determine whether or not equol can explain the chemopreventive effect of soy. In the present study, a single oral dose of 5 mg 7,12-dimethylbenz(a)anthracene (DMBA) was administered to 120 rats. After ovariectomy, these rats were divided into eight different treatment groups: control group (CG); high isoflavone (HI); middle isoflavone (MI); low isoflavone (Li); high equol (HE); middle equol (ME); low equol (LE); and oestrogen group (EG). At week 24 after DMBA was administered, tumour incidences were 60% (9/15) in CG, 13.3% (2/15) in the MI group, 13.3% (2/15) in the Li group, 6.7% (1/15) in the LE group, and 73.3% (11/15) in EG. Isoflavone/equol groups exhibited significantly lower incidences of tumour and longer mean latent period compared with CG and EG. Thiobarbituric acid reactive substances were significantly decreased in the plasma of the rats in HI and MI groups as well as in equol treatment groups compared with CG. Moreover, RT-PCR and western blotting show that the mRNA and protein expression levels of ER alpha and ER beta were significantly higher in isoflavone/equol treatment groups than in CG. In conclusion, isoflavone/equol intake can significantly inhibit the development of post-menopausal mammary tumours by antioxidant activities and oestrogenic activities. (C) 2014 Elsevier Ltd. All rights reserved.

语种: 英语
所属项目编号: 81172653 ; 30872115 ; 30872114 ; 81202193 ; 7122103
项目资助者: National Natural Science Foundation of China ; Beijing Natural Science Foundation
WOS记录号: WOS:000335203500059
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内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53293
Appears in Collections:北京大学公共卫生学院_期刊论文

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作者单位: 1.Peking Univ, Hlth Sci Ctr, Sch Publ Hlth, Dept Social Med & Hlth Educ, Beijing 100191, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Sch Publ Hlth, Dept Nutr & Food Hyg, Beijing 100191, Peoples R China

Recommended Citation:
Ma, Defu,Zhang, Yumei,Xue, Yong,et al. Isoflavone and its metabolite equol inhibit the development of 7,12-dimethylbenz(a)anthracene (DMBA)-induced mammary tumours in ovariectomised rats[J]. JOURNAL OF FUNCTIONAL FOODS,2014,7:580-589.
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