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学科主题临床医学
Drug-Path: a database for drug-induced pathways
Zeng, Hui1; Qiu, Chengxiang2; Cui, Qinghua2
刊名DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION
2015-06-30
DOI10.1093/database/bav061
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Mathematical & Computational Biology
研究领域[WOS]Mathematical & Computational Biology
关键词[WOS]KYOTO ENCYCLOPEDIA ; GENES ; DISCOVERY ; DISEASE ; GENOMES ; SMPDB ; KEGG
英文摘要

Some databases for drug-associated pathways have been built and are publicly available. However, the pathways curated in most of these databases are drug-action or drug-metabolism pathways. In recent years, high-throughput technologies such as microarray and RNA-sequencing have produced lots of drug-induced gene expression profiles. Interestingly, drug-induced gene expression profile frequently show distinct patterns, indicating that drugs normally induce the activation or repression of distinct pathways. Therefore, these pathways contribute to study the mechanisms of drugs and drug-repurposing. Here, we present Drug-Path, a database of drug-induced pathways, which was generated by KEGG pathway enrichment analysis for drug-induced upregulated genes and downregulated genes based on drug-induced gene expression datasets in Connectivity Map. Drug-Path provides user-friendly interfaces to retrieve, visualize and download the drug-induced pathway data in the database. In addition, the genes deregulated by a given drug are highlighted in the pathways. All data were organized using SQLite. The web site was implemented using Django, a Python web framework. Finally, we believe that this database will be useful for related researches.

语种英语
WOS记录号WOS:000361053000002
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53298
专题北京大学第三临床医学院_心血管内科
北京大学基础医学院
作者单位1.Peking Univ, Hosp 3, Dept Cardiol, Beijing 100191, Peoples R China
2.Peking Univ, Sch Basic Med Sci, MOE Key Lab Cardiovasc Sci, Dept Biomed Informat, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Zeng, Hui,Qiu, Chengxiang,Cui, Qinghua. Drug-Path: a database for drug-induced pathways[J]. DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION,2015.
APA Zeng, Hui,Qiu, Chengxiang,&Cui, Qinghua.(2015).Drug-Path: a database for drug-induced pathways.DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION.
MLA Zeng, Hui,et al."Drug-Path: a database for drug-induced pathways".DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION (2015).
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