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学科主题: 临床医学
题名:
Drug-Path: a database for drug-induced pathways
作者: Zeng, Hui1; Qiu, Chengxiang2; Cui, Qinghua2
刊名: DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION
发表日期: 2015-06-30
DOI: 10.1093/database/bav061
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Mathematical & Computational Biology
研究领域[WOS]: Mathematical & Computational Biology
关键词[WOS]: KYOTO ENCYCLOPEDIA ; GENES ; DISCOVERY ; DISEASE ; GENOMES ; SMPDB ; KEGG
英文摘要:

Some databases for drug-associated pathways have been built and are publicly available. However, the pathways curated in most of these databases are drug-action or drug-metabolism pathways. In recent years, high-throughput technologies such as microarray and RNA-sequencing have produced lots of drug-induced gene expression profiles. Interestingly, drug-induced gene expression profile frequently show distinct patterns, indicating that drugs normally induce the activation or repression of distinct pathways. Therefore, these pathways contribute to study the mechanisms of drugs and drug-repurposing. Here, we present Drug-Path, a database of drug-induced pathways, which was generated by KEGG pathway enrichment analysis for drug-induced upregulated genes and downregulated genes based on drug-induced gene expression datasets in Connectivity Map. Drug-Path provides user-friendly interfaces to retrieve, visualize and download the drug-induced pathway data in the database. In addition, the genes deregulated by a given drug are highlighted in the pathways. All data were organized using SQLite. The web site was implemented using Django, a Python web framework. Finally, we believe that this database will be useful for related researches.

语种: 英语
所属项目编号: 91339106
项目资助者: Natural Science Foundation of China
WOS记录号: WOS:000361053000002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53298
Appears in Collections:北京大学第三临床医学院_心血管内科_期刊论文

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作者单位: 1.Peking Univ, Hosp 3, Dept Cardiol, Beijing 100191, Peoples R China
2.Peking Univ, Sch Basic Med Sci, MOE Key Lab Cardiovasc Sci, Dept Biomed Informat, Beijing 100191, Peoples R China

Recommended Citation:
Zeng, Hui,Qiu, Chengxiang,Cui, Qinghua. Drug-Path: a database for drug-induced pathways[J]. DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION,2015.
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