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学科主题: 临床医学
题名:
Measuring depressive symptoms using the Patient Health Questionnaire-9 in Hong Kong Chinese subjects with type 2 diabetes
作者: Zhang, Yuying1; Ting, Rose1; Lam, Marco2; Lam, Joyce2; Nan, Hairong3; Yeung, Roseanne1,4; Yang, Wenying5; Ji, Linong6; Weng, Jianping7; Wing, Yun-Kwok2; Sartorius, Norman8; Chan, Juliana C. N.1,3
关键词: Depression ; Type 2 diabetes ; Chinese ; Patient Health Questionnaire-9 ; Glycemic control ; Somatization
刊名: JOURNAL OF AFFECTIVE DISORDERS
发表日期: 2013-11-01
DOI: 10.1016/j.jad.2013.07.014
卷: 151, 期:2, 页:660-666
收录类别: SCI ; SSCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Clinical Neurology ; Psychiatry
研究领域[WOS]: Neurosciences & Neurology ; Psychiatry
关键词[WOS]: INTERNATIONAL NEUROPSYCHIATRIC INTERVIEW ; GLYCEMIC VARIABILITY ; MAJOR DEPRESSION ; RISK-FACTORS ; DSM-IV ; METAANALYSIS ; ASSOCIATION ; PREVALENCE ; IMPACT ; LIFE
英文摘要:

Background: Depression is common in type 2 diabetes although the prevalence in Chinese patients remains unclear. We validated the Patient Health Questionnaire(PHQ-9), a popular depression screening tool, in Chinese with type 2 diabetes, and documented the prevalence, demographic,and clinical characteristics associated with depression.

Methods: A consecutive cohort of 586 Hong Kong Chinese outpatients completed the PHQ-9 during comprehensive diabetes complication assessment. Within 2-4 weeks, 40 patients were retested via telephone survey. Ninety-nine randomly selected patients were interviewed by psychiatrists using the Mini Internarional Neuropsychiatric Interview as a golden standard. Receiver operating characteristic curve was used to assess performance of the PHQ-9.

Results: The internal consistency of the PHQ-9 was 0.86 and test-rerest reliability was 0.70. The 3 somatic items explained 53.6% of the PHQ-9 score. The optimal cutoff value was 7 with 82.6% sensitivity and 73.7% specificity, giving a depression prevalence of 18.3% (n=107). Of these, 18.7% had been previously diagnosed with depression. Depression was more prevalent in women than men. After controlling for confounders, patients with depression had higher HbA1c [7.80 +/- 1.86% versus 7.43 +/- 1.29%, 161.7 +/- 20.4 versus 57.8 +/- 14.1 mmol/mol], P < 0.05), reduced likelihood of achieving HbA1c target of <7.0% (33.6% versus 41.8%, P<0.05), and were more likely to have self-reported hypoglycemia in the previous 3 months (18.7% versus 6.7%, P < 0.01).

Limitation: A small sample was used in the criterion validation and the cross-sectional design precludes causal inference.

Conclusions: PHQ-9 is a validated tool for screening for depression, which is common and frequently undiagnosed in Chinese type 2 diabetic patients and is associated with suboptimal glycemic control, hypoglycemia, and somatization. (C) 2013 Elsevier B.V. All rights reserved

语种: 英语
项目资助者: European Foundation for Study of Diabetes ; Chinese Diabetes Society ; Lilly Foundation ; Asia Diabetes Foundation ; Liao Wun Yuk Diabetes Memorial Fund ; Chinese University of Hong Kong
WOS记录号: WOS:000325432900034
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53299
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: 1.Chinese Univ Hong Kong, Prince Wales Hosp, Dept Med & Therapeut, Shatin, Hong Kong, Peoples R China
2.Chinese Univ Hong Kong, Prince Wales Hosp, Dept Psychiat, Shatin, Hong Kong, Peoples R China
3.Chinese Univ Hong Kong, Prince Wales Hosp, Hong Kong Inst Diabet & Obes, Shatin, Hong Kong, Peoples R China
4.Univ British Columbia, Div Endocrinol, Vancouver, BC V5Z 1M9, Canada
5.China Japan Friendship Hosp, Dept Endocrinol, Beijing, Peoples R China
6.Peking Univ, Peoples Hosp, Dept Endocrinol & Metab, Beijing 100871, Peoples R China
7.Sun Yat Sen Univ, Affiliated Hosp 3, Dept Endocrinol, Guangzhou 510275, Guangdong, Peoples R China
8.Assoc Improvement Mental Hlth Programmes, Geneva, Switzerland

Recommended Citation:
Zhang, Yuying,Ting, Rose,Lam, Marco,et al. Measuring depressive symptoms using the Patient Health Questionnaire-9 in Hong Kong Chinese subjects with type 2 diabetes[J]. JOURNAL OF AFFECTIVE DISORDERS,2013,151(2):660-666.
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