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学科主题基础医学
The NO/sGC/PKG Signaling Pathway in the NAc Shell Is Necessary for the Acquisition of Morphine-Induced Place Preference
Shen, Fang1,2,3; Wang, Na1,2,3; Qi, Chong1,2,3; Li, Yi-Jing1,2,3; Cui, Cai-Lian1,2,3
关键词nitric oxide signaling pathway morphine conditioned place preference nucleus accumbens
刊名BEHAVIORAL NEUROSCIENCE
2014-08-01
DOI10.1037/a0036964
128期:4页:446-459
收录类别SCI ; SSCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Behavioral Sciences ; Neurosciences
研究领域[WOS]Behavioral Sciences ; Neurosciences & Neurology
关键词[WOS]NITRIC-OXIDE SYNTHASE ; LONG-TERM POTENTIATION ; NUCLEUS-ACCUMBENS CORE ; GUANYLATE-CYCLASE ; SYNAPTIC PLASTICITY ; VENTRAL STRIATUM ; S-NITROSYLATION ; FEAR MEMORY ; RAT ; 7-NITROINDAZOLE
英文摘要

There is evidence that the nitric oxide (NO)/soluble guanylyl cyclase (sGC)/cGMP-dependent protein kinase (PKG) signaling pathway in the basal lateral amygdala and hippocampus plays a key role in memory processing, but it is not known if this NO signaling pathway in the nucleus accumbens (Gomes et al., 2006), a known pivotal region in reward memory, is essential for drug-associated reward memory. We therefore investigated the effect of the NO/sGC/PKG signaling pathway in the nucleus accumbens (NAc) on morphine-induced conditioned place preference (CPP). Results showed that a preconditioning microinjection of the NO synthase (NOS) inhibitor N-omega-nitro-L-arginine methyl ester (L-NAME) into the NAc shell, but not into the core, significantly blocked the acquisition of morphine CPP. The blockage effect of L-NAME on the acquisition of CPP was imitated by the neuronal NOS inhibitor 7-nitroindazole, 3-bromo-, sodium salt (7-NI), the sGC inhibitor 1H-[1,2,4] oxadiazolo-[4,3-a]quinoxalin-1-one (ODQ), and the PKG inhibitor Rp-8Br-PET-cGMPS. The 7-NI-or ODQ-induced effect was reversed by premicroinjection of the sGC activator YC-1 or the PKG activator 8-Br-cGMP in the NAc shell. However, microinfusion of 7-NI, ODQ, or Rp-8Br-PET-cGMPS into the NAc shell or the core had no effect on the expression of morphine CPP. These findings indicate that the NO/sGC/PKG signaling pathway in the NAc shell is critical for the acquisition of morphine-induced place preference, whereas the same signaling pathway in the NAc shell or core is not involved in the retrieval of morphine-induced place preference.

语种英语
WOS记录号WOS:000349169300004
项目编号31271163 ; 81221002
资助机构National Natural Science Foundation ; National Natural Science Foundation of China
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53302
专题北京大学基础医学院_神经生物学系
北京大学基础医学院
北京大学第三临床医学院_儿科
作者单位1.Peking Univ, Neurosci Res Inst, Beijing 100191, Peoples R China
2.Peking Univ, Dept Neurobiol, Beijing 100191, Peoples R China
3.Minist Educ, Key Lab Neurosci, Beijing, Peoples R China
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Shen, Fang,Wang, Na,Qi, Chong,et al. The NO/sGC/PKG Signaling Pathway in the NAc Shell Is Necessary for the Acquisition of Morphine-Induced Place Preference[J]. BEHAVIORAL NEUROSCIENCE,2014,128(4):446-459.
APA Shen, Fang,Wang, Na,Qi, Chong,Li, Yi-Jing,&Cui, Cai-Lian.(2014).The NO/sGC/PKG Signaling Pathway in the NAc Shell Is Necessary for the Acquisition of Morphine-Induced Place Preference.BEHAVIORAL NEUROSCIENCE,128(4),446-459.
MLA Shen, Fang,et al."The NO/sGC/PKG Signaling Pathway in the NAc Shell Is Necessary for the Acquisition of Morphine-Induced Place Preference".BEHAVIORAL NEUROSCIENCE 128.4(2014):446-459.
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