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学科主题: 基础医学
题名:
The NO/sGC/PKG Signaling Pathway in the NAc Shell Is Necessary for the Acquisition of Morphine-Induced Place Preference
作者: Shen, Fang1,2,3; Wang, Na1,2,3; Qi, Chong1,2,3; Li, Yi-Jing1,2,3; Cui, Cai-Lian1,2,3
关键词: nitric oxide signaling pathway ; morphine ; conditioned place preference ; nucleus accumbens
刊名: BEHAVIORAL NEUROSCIENCE
发表日期: 2014-08-01
DOI: 10.1037/a0036964
卷: 128, 期:4, 页:446-459
收录类别: SCI ; SSCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Behavioral Sciences ; Neurosciences
研究领域[WOS]: Behavioral Sciences ; Neurosciences & Neurology
关键词[WOS]: NITRIC-OXIDE SYNTHASE ; LONG-TERM POTENTIATION ; NUCLEUS-ACCUMBENS CORE ; GUANYLATE-CYCLASE ; SYNAPTIC PLASTICITY ; VENTRAL STRIATUM ; S-NITROSYLATION ; FEAR MEMORY ; RAT ; 7-NITROINDAZOLE
英文摘要:

There is evidence that the nitric oxide (NO)/soluble guanylyl cyclase (sGC)/cGMP-dependent protein kinase (PKG) signaling pathway in the basal lateral amygdala and hippocampus plays a key role in memory processing, but it is not known if this NO signaling pathway in the nucleus accumbens (Gomes et al., 2006), a known pivotal region in reward memory, is essential for drug-associated reward memory. We therefore investigated the effect of the NO/sGC/PKG signaling pathway in the nucleus accumbens (NAc) on morphine-induced conditioned place preference (CPP). Results showed that a preconditioning microinjection of the NO synthase (NOS) inhibitor N-omega-nitro-L-arginine methyl ester (L-NAME) into the NAc shell, but not into the core, significantly blocked the acquisition of morphine CPP. The blockage effect of L-NAME on the acquisition of CPP was imitated by the neuronal NOS inhibitor 7-nitroindazole, 3-bromo-, sodium salt (7-NI), the sGC inhibitor 1H-[1,2,4] oxadiazolo-[4,3-a]quinoxalin-1-one (ODQ), and the PKG inhibitor Rp-8Br-PET-cGMPS. The 7-NI-or ODQ-induced effect was reversed by premicroinjection of the sGC activator YC-1 or the PKG activator 8-Br-cGMP in the NAc shell. However, microinfusion of 7-NI, ODQ, or Rp-8Br-PET-cGMPS into the NAc shell or the core had no effect on the expression of morphine CPP. These findings indicate that the NO/sGC/PKG signaling pathway in the NAc shell is critical for the acquisition of morphine-induced place preference, whereas the same signaling pathway in the NAc shell or core is not involved in the retrieval of morphine-induced place preference.

语种: 英语
所属项目编号: 31271163 ; 81221002
项目资助者: National Natural Science Foundation ; National Natural Science Foundation of China
WOS记录号: WOS:000349169300004
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53302
Appears in Collections:基础医学院_神经生物学系_期刊论文

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作者单位: 1.Peking Univ, Neurosci Res Inst, Beijing 100191, Peoples R China
2.Peking Univ, Dept Neurobiol, Beijing 100191, Peoples R China
3.Minist Educ, Key Lab Neurosci, Beijing, Peoples R China

Recommended Citation:
Shen, Fang,Wang, Na,Qi, Chong,et al. The NO/sGC/PKG Signaling Pathway in the NAc Shell Is Necessary for the Acquisition of Morphine-Induced Place Preference[J]. BEHAVIORAL NEUROSCIENCE,2014,128(4):446-459.
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