北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第一临床医学院  > 肾脏内科  > 期刊论文
学科主题: 临床医学
题名:
Mortality and renal function decline among a community-based Chinese population with normal or mildly impaired renal function
作者: Wang, Fang1; Zhang, Luxia1; Zuo, Li1; Liu, Lisheng2; Wang, Haiyan1
关键词: Chinese ; chronic kidney disease ; epidemiology ; mortality ; progression
刊名: NEPHROLOGY DIALYSIS TRANSPLANTATION
发表日期: 2011-09-01
DOI: 10.1093/ndt/gfq816
卷: 26, 期:9, 页:2847-U1506
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Transplantation ; Urology & Nephrology
研究领域[WOS]: Transplantation ; Urology & Nephrology
关键词[WOS]: CHRONIC KIDNEY-DISEASE ; GLOMERULAR-FILTRATION-RATE ; URIC-ACID LEVEL ; CARDIOVASCULAR-DISEASE ; INCIDENT HYPERTENSION ; BLOOD-PRESSURE ; PROTEIN-INTAKE ; RISK-FACTORS ; PROGRESSION ; PREVALENCE
英文摘要:

Background. Longitudinal studies of the mortality and renal outcomes among the population with an estimated glomerular filtration rate (eGFR) > 30 mL/min/1.73m(2) and among the elderly are limited, especially in developing countries.

Methods. This prospective cohort study included 1563 residents aged 59.5 +/- 9.4 years from an urban district of Beijing, China. All participants had an eGFR > 30 mL/min/1.73m(2). Urinary albumin-to-creatinine ratio and eGFR were assessed at baseline, and their relation with mortality and renal function decline after a 4-year follow-up were analyzed.

Results. During 4 years (6142 person-years) of follow-up, 59 deaths occurred (9.6 per 1000 person-years). After adjusting for potential confounders, albuminuria was associated with increased risk of mortality, with an odds ratio (OR) of 3.09 [95% confidence interval (CI) 1.53-6.26]. Altogether 183 patients (12.3%) developed renal function decline, with a median change of eGFR of -20.0 mL/min/1.73m(2). Presence of albuminuria was significantly associated renal function decline, with an OR of 1.79 (95% CI 1.02-3.15). Plasma uric acid (OR 1.25/59 lmol/L increase, 95% CI 1.10-1.43) and age (OR 1.35/5 years increase, 95% CI 1.22-1.50) was also independently associated with renal function decline. Baseline eGFR was not significantly associated with either mortality or renal function decline in our analysis.

Conclusions. Compared with eGFR, albuminuria is a strong independent predictor for both mortality and renal function decline among a Chinese population with normal or mildly impaired renal function. Furthermore, plasma uric acid level and age are also independently associated with renal function decline and therefore may be used for identifying patients at higher risk of chronic kidney disease progression.

语种: 英语
项目资助者: China Health and Medical Development Foundation ; Beijing Municipal Science and Technology Commission ; International Society of Nephrology
WOS记录号: WOS:000295231600019
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53303
Appears in Collections:北京大学第一临床医学院_肾脏内科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Peking Univ, Hosp 1, Dept Med, Div Renal, Beijing 100871, Peoples R China
2.Beijing Hypertens League Inst, Beijing, Peoples R China

Recommended Citation:
Wang, Fang,Zhang, Luxia,Zuo, Li,et al. Mortality and renal function decline among a community-based Chinese population with normal or mildly impaired renal function[J]. NEPHROLOGY DIALYSIS TRANSPLANTATION,2011,26(9):2847-U1506.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Wang, Fang]'s Articles
[Zhang, Luxia]'s Articles
[Zuo, Li]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Wang, Fang]‘s Articles
[Zhang, Luxia]‘s Articles
[Zuo, Li]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace