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学科主题基础医学
Acute dichlorvos poisoning induces hemorheological abnormalities in rabbits via oxidative stress
Zhang, Xiaolan1; Yao, Weijuan1; Chen, Dan1; Jia, Binbin2; Sun, Dagong1; Ka, Weibo1; He, Dongqi1; Wang, Xifu3; Wen, Zongyao1
关键词Dichlorvos poisoning oxidative stress hemorheology hematocrit adjusted viscosity
刊名CLINICAL HEMORHEOLOGY AND MICROCIRCULATION
2010
DOI10.3233/CH-2010-1264
44期:3页:207-216
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Hematology ; Peripheral Vascular Disease
研究领域[WOS]Hematology ; Cardiovascular System & Cardiology
关键词[WOS]RED-BLOOD-CELLS ; LIPID-PEROXIDATION ; ORGANOPHOSPHORUS PESTICIDES ; VITAMIN-E ; RATS ; PARAMETERS ; TOXICITY ; ERYTHROCYTES ; POLARIZATION ; BIOCHEMISTRY
英文摘要

Dichlorvos is an important insecticide used largely. Some studies have demonstrated that organophosphate pesticide has effects on erythrocyte membrane structures, which is critical to erythrocyte function and hemorheology. The aim of the present study was to explore the effect of oxidative stress on hemorheological changes during dichlorvos poisoning in rabbits. Data indicated that after dichlorvos exposure the hematocrit adjusted viscosity at high shear rate increased and erythrocyte membrane fluidity decreased. Data obtained from plasma showed that lipid peroxidative substance-malonaldehyde was elevated and superoxide dismutase was reduced. In summary, oxidative stress does occur in dichlorvos poisoning and may lead to hemorheological alterations. The changes of hemorheology may be responsible for the pathophysiology of the dichlorvos poisoning.

语种英语
WOS记录号WOS:000276442500006
引用统计
被引频次:10[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53304
专题北京大学基础医学院_生物物理学系
北京大学基础医学院
医学人文研究院/公共教学部_哲学与社会科学系
作者单位1.Peking Univ, Hlth Sci Ctr, Dept Biophys, Hemorheol Ctr, Beijing 100191, Peoples R China
2.Chengde Med Coll, Chengde, Hebei Province, Peoples R China
3.Peking Univ, Shougang Hosp, Dept Cardiol, Beijing 100144, Peoples R China
推荐引用方式
GB/T 7714
Zhang, Xiaolan,Yao, Weijuan,Chen, Dan,et al. Acute dichlorvos poisoning induces hemorheological abnormalities in rabbits via oxidative stress[J]. CLINICAL HEMORHEOLOGY AND MICROCIRCULATION,2010,44(3):207-216.
APA Zhang, Xiaolan.,Yao, Weijuan.,Chen, Dan.,Jia, Binbin.,Sun, Dagong.,...&Wen, Zongyao.(2010).Acute dichlorvos poisoning induces hemorheological abnormalities in rabbits via oxidative stress.CLINICAL HEMORHEOLOGY AND MICROCIRCULATION,44(3),207-216.
MLA Zhang, Xiaolan,et al."Acute dichlorvos poisoning induces hemorheological abnormalities in rabbits via oxidative stress".CLINICAL HEMORHEOLOGY AND MICROCIRCULATION 44.3(2010):207-216.
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