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学科主题: 基础医学
题名:
Acute dichlorvos poisoning induces hemorheological abnormalities in rabbits via oxidative stress
作者: Zhang, Xiaolan1; Yao, Weijuan1; Chen, Dan1; Jia, Binbin2; Sun, Dagong1; Ka, Weibo1; He, Dongqi1; Wang, Xifu3; Wen, Zongyao1
关键词: Dichlorvos poisoning ; oxidative stress ; hemorheology ; hematocrit adjusted viscosity
刊名: CLINICAL HEMORHEOLOGY AND MICROCIRCULATION
发表日期: 2010
DOI: 10.3233/CH-2010-1264
卷: 44, 期:3, 页:207-216
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Hematology ; Peripheral Vascular Disease
研究领域[WOS]: Hematology ; Cardiovascular System & Cardiology
关键词[WOS]: RED-BLOOD-CELLS ; LIPID-PEROXIDATION ; ORGANOPHOSPHORUS PESTICIDES ; VITAMIN-E ; RATS ; PARAMETERS ; TOXICITY ; ERYTHROCYTES ; POLARIZATION ; BIOCHEMISTRY
英文摘要:

Dichlorvos is an important insecticide used largely. Some studies have demonstrated that organophosphate pesticide has effects on erythrocyte membrane structures, which is critical to erythrocyte function and hemorheology. The aim of the present study was to explore the effect of oxidative stress on hemorheological changes during dichlorvos poisoning in rabbits. Data indicated that after dichlorvos exposure the hematocrit adjusted viscosity at high shear rate increased and erythrocyte membrane fluidity decreased. Data obtained from plasma showed that lipid peroxidative substance-malonaldehyde was elevated and superoxide dismutase was reduced. In summary, oxidative stress does occur in dichlorvos poisoning and may lead to hemorheological alterations. The changes of hemorheology may be responsible for the pathophysiology of the dichlorvos poisoning.

语种: 英语
所属项目编号: 10572007 ; 30770532 ; 1102032
项目资助者: National Science Foundation in China ; Beijing Natural Science Foundation in China
WOS记录号: WOS:000276442500006
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53304
Appears in Collections:基础医学院_生物物理学系_期刊论文

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作者单位: 1.Peking Univ, Hlth Sci Ctr, Dept Biophys, Hemorheol Ctr, Beijing 100191, Peoples R China
2.Chengde Med Coll, Chengde, Hebei Province, Peoples R China
3.Peking Univ, Shougang Hosp, Dept Cardiol, Beijing 100144, Peoples R China

Recommended Citation:
Zhang, Xiaolan,Yao, Weijuan,Chen, Dan,et al. Acute dichlorvos poisoning induces hemorheological abnormalities in rabbits via oxidative stress[J]. CLINICAL HEMORHEOLOGY AND MICROCIRCULATION,2010,44(3):207-216.
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