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学科主题: 基础医学
题名:
MALT lymphoma with t(14;18)(q32;q21)/IGH-MALT1 is characterized by strong cytoplasmic MALT1 and BCL10 expression
作者: Ye, HT1; Gong, LP1; Liu, HX1; Hamoudi, RA1; Shirali, S1; Ho, L1; Chott, A1; Streubel, B1; Siebert, R1; Gesk, S1; Martin-Subero, JI1; Radford, JA1; Banerjee, S1; Nicholson, AG1; Ranaldi, R1; Remstein, ED1; Gao, ZF1; Zheng, J1; Isaacson, PG1; Dogan, A1; Du, MQ1
关键词: MALT lymphoma ; MALT1 ; Bcl10 ; translocation ; molecular cytogenetics
刊名: JOURNAL OF PATHOLOGY
发表日期: 2005-02-01
DOI: 10.1002/path.1715
卷: 205, 期:3, 页:293-301
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology ; Pathology
研究领域[WOS]: Oncology ; Pathology
关键词[WOS]: NF-KAPPA-B ; HELICOBACTER-PYLORI ERADICATION ; TISSUE LYMPHOMAS ; CELL LYMPHOMA ; CHROMOSOMAL TRANSLOCATION ; API2-MLT FUSION ; MARGINAL ZONE ; NUCLEAR BCL10 ; T(11/18)(Q21,Q21) ; GENE
英文摘要:

Mucosa-associated lymphoid tissue (MALT) lymphoma is specifically associated with t(11:18)(q21;q21), t(1;14)(p22;q32) and t(14;18)(q32;q21). t(11;18)(q21;q21) fuses the N-terminus of the AP12 gene to the C-terminus of the MALT1 gene and generates a API2-MALT1 product. t(1;14)(p22;q32) and t(14;18)(q32;q21) bring the BCL10 genes respectively to the IGH locus and deregulate their expression. The oncology activity of the three chromosomal translocations is linked by the physiological role of BCL10 and MALT1 in antigen receptor-mediated NFkappaB activation. In this study, MALT1 and BCL10 expression was examined in normal lymphoid tissues and 423 cases of MALT lymphoma from eight sites, and their expression was correlated with the above translocations, which were detected by molecular and molecular cytogenetic methods. In normal B-cell follicles, both MALT1 and BCL10 were expressed predominantly in the cytoplasm, high in centroblasts, moderate in centrocytes and weak/negative in mantle zone B-cells. In MALT lymphoma, MALT1 and BCL10 expression varied among cases with different chromosomal translocations. In 9/9 MALT lymphomas with t(14;18)(q32;q21), tumour cells showed strong homogeneous cytoplasmic expression of both MALT1 and BCL10. In 12/12 cases with evidence of t(1;14)(p22;q32) or variants, tumour cells expressed MALT1 weakly in the cytoplasm but BCL10 strongly in the nuclei. In all 67 MALT lymphomas with t(11;18)(q21;q21), tumour cells expressed weak cytoplasmic MALT1 and moderate nuclear BCL10. In MALT lymphomas without the above translocations, both MALT1 and BCL10, in general, were expressed weakly in the cytoplasm. Real-time quantitative RT-PCR showed a good correlation between MALT1 and BCL10 mRNA expression and underlining genetic changes, with t(14;18)(q32;q21)- and t(1;14)(p22;q32)-positive cases displaying the highest MALT1 and BCL10 mRNA expression respectively. These results show that MALT1 expression pattern is identical to that of BCL10 in normal lymphoid tissues but varies in MALT lymphomas, with high cytoplasmic expression of both MALT1 and BCL10 characterizing those with t(14;18)(q32;q21). Copyright (C) 2005 Pathological Society of Great Britain and Ireland. Published by John Wiley Sons, Ltd.

语种: 英语
WOS记录号: WOS:000226912400001
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53307
Appears in Collections:基础医学院_病理学系_期刊论文

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作者单位: 1.Mayo Clin & Mayo Fdn, Div Anat Pathol, Rochester, MN 55905 USA
2.Mayo Clin & Mayo Fdn, Div Hematopathol, Rochester, MN 55905 USA
3.Univ Cambridge, Addenbrookes Hosp, Dept Pathol, Div Mol Histopathol, Cambridge CB2 2QQ, England
4.Beijing Univ, Dept Pathol, Hlth Sci Ctr, Beijing 100871, Peoples R China
5.CMU, Dept Clin Pathol, Geneva, Switzerland
6.Univ Vienna, Dept Clin Pathol, A-1010 Vienna, Austria
7.Univ Hosp Schleswig Holstein, Inst Human Genet, Kiel, Germany
8.Christie Hosp, Dept Med Oncol, Canc Res UK, Manchester, Lancs, England
9.Christie Hosp, Dept Pathol, Manchester, Lancs, England
10.Royal Brompton Hosp, Dept Histopathol, London SW3 6LY, England
11.Inst Pathol Anat & Histopathol, Dept Pathol, Ancona, Italy
12.Univ London Kings Coll, Dept Histopathol, London WC2R 2LS, England

Recommended Citation:
Ye, HT,Gong, LP,Liu, HX,et al. MALT lymphoma with t(14;18)(q32;q21)/IGH-MALT1 is characterized by strong cytoplasmic MALT1 and BCL10 expression[J]. JOURNAL OF PATHOLOGY,2005,205(3):293-301.
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