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IR@PKUHSC  > 北京大学第二临床医学院  > 血液科  > 期刊论文
学科主题: 临床医学
题名:
Presence of CD34(+)CD38(-)CD58(-) leukemia-propagating cells at diagnosis identifies patients at high risk of relapse with Ph chromosome-positive ALL after allo-hematopoietic SCT
作者: Kong, Y.1; Xu, L-P1; Liu, Y-R1; Qin, Y-Z1; Sun, Y-Q1; Wang, Y.1; Jiang, H.1; Jiang, Q.1; Chen, H.1; Chang, Y-J1; Huang, X-J1,2
刊名: BONE MARROW TRANSPLANTATION
发表日期: 2015-03-01
DOI: 10.1038/bmt.2014.274
卷: 50, 期:3, 页:348-353
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biophysics ; Oncology ; Hematology ; Immunology ; Transplantation
研究领域[WOS]: Biophysics ; Oncology ; Hematology ; Immunology ; Transplantation
关键词[WOS]: ACUTE LYMPHOBLASTIC-LEUKEMIA ; ACUTE MYELOID-LEUKEMIA ; MINIMAL RESIDUAL DISEASE ; MULTICOLOR FLOW-CYTOMETRY ; POLYMERASE-CHAIN-REACTION ; TRANSCRIPT LEVELS ; CANCER PROGRAM ; IMATINIB ; TRANSPLANTATION ; SURVIVAL
英文摘要:

Relapse of Ph chromosome-positive ALL (Ph(+)ALL) results from the persistence of leukemia-propagating cells (LPCs). In Ph(+)ALL, a xenograft assay recently determined that LPCs are enriched in the CD34(+)CD38(-)CD58(-) fraction. Therefore, the prognostic significance of LPCs in Ph+ALL subjects after allogeneic hematopoietic SCT (allo-HSCT) was investigated. A total of 80 consecutive adults with Ph+ALL who underwent allo-HSCT were eligible. A multi-parameter flow cytometry analysis examining CD58-FITC/CD10-PE/CD19-APC-Cy7/CD34-PerCP/CD45-Vioblue/CD38-APC on gated leukemia BM blasts was performed at diagnosis. Based on the original blast phenotypes, subjects were stratified into the CD34(+)CD38(-)CD58(-) group (N = 15) and other phenotype group (N = 65). During minimal residual disease monitoring, significantly higher levels of BCR/ABL transcripts were detected in subjects in the CD34(+)CD38(-)CD58(-) group than in other phenotype group, especially at 3 months post HSCT. In addition, CD34(+)CD38(-)CD58(-) LPCs are directly correlated with a higher 3-year cumulative incidence of relapse (CIR) and worse leukemia-free survival (LFS) and OS. Multivariate analyses indicated that presence of CD34(+)CD38(-)CD58(-) LPCs at diagnosis, and BCR-ABL reduction at 3 months post HSCT were independent risk factors for relapse, LFS and OS. Our data suggest that presence of CD34(+)CD38(-)CD58(-) LPCs at diagnosis allows rapid identification of high-risk patients for relapse after allo-HSCT.

语种: 英语
所属项目编号: 81370638 ; 81230013 ; RDB2012-23
项目资助者: National Natural Science Foundation of China ; Beijing Municipal Science and Technology Program ; National Clinical Priority Specialty ; Peking University People&prime ; s Hospital Research and Development Funds
WOS记录号: WOS:000351632000005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53316
Appears in Collections:北京大学第二临床医学院_血液科_期刊论文

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作者单位: 1.Peking Univ, Peoples Hosp, Inst Hematol, Beijing Key Lab Hematopoiet Stem Cell Transplanta, Beijing 100044, Peoples R China
2.Peking Univ, Peking Tsinghua Ctr Life Sci, Beijing 100044, Peoples R China

Recommended Citation:
Kong, Y.,Xu, L-P,Liu, Y-R,et al. Presence of CD34(+)CD38(-)CD58(-) leukemia-propagating cells at diagnosis identifies patients at high risk of relapse with Ph chromosome-positive ALL after allo-hematopoietic SCT[J]. BONE MARROW TRANSPLANTATION,2015,50(3):348-353.
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