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学科主题: 临床医学
题名:
Role of C9orf140 in the promotion of colorectal cancer progression and mechanisms of its upregulation via activation of STAT5, beta-catenin and EZH2
作者: Weng, Yu-Rong1; Yu, Ya-Nan1; Ren, Lin-Lin1,2; Cui, Yun1; Lu, You-Yong3; Chen, Hao-Yan1; Ma, Xiong1; Qin, Wen-Xin4; Cao, Weibiao5,6; Hong, Jie1; Fang, Jing-Yuan1
刊名: CARCINOGENESIS
发表日期: 2014-06-01
DOI: 10.1093/carcin/bgu057
卷: 35, 期:6, 页:1389-1398
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: EPITHELIAL-MESENCHYMAL TRANSITION ; CELL-ADHESION MOLECULES ; COLON-CANCER ; HEPATOCELLULAR-CARCINOMA ; TUMOR PROGRESSION ; GASTRIC-CANCER ; EXPRESSION ; METASTASIS ; CADHERINS ; CONTRIBUTES
英文摘要:

C9orf140 is a newly identified and characterized gene which is associated with cell proliferation and tumorigenicity. Expression of C9orf140 is upregulated in human gastric cancer and colorectal cancer (CRC); however, little is known about its role in CRC progression. We have investigated the clinical significance, biological effects and mechanisms of C9orf140 signaling. We found that the expression of C9orf140 is dramatically increased in a subset of CRC and correlates significantly with vascular invasion and lymph node metastasis. Our finding showed that knockdown of C9orf140 significantly reduced cell proliferation and invasion in vitro and dramatically increased overall survival and decreased lung metastasis in vivo. Conversely, overexpression of C9orf140 significantly increased lung metastasis and shortened overall survival when compared with control tumors. C9orf140-induced CRC cell invasion may depend on promoting the epithelial-mesenchymal transition progression. STAT5 may directly interact with the enhancer of zeste homolog 2 (EZH2) and beta-catenin to enhance C9orf140 gene transactivation. Furthermore, C9orf140 may participate in cell invasion which is induced by STAT5, EZH2 or beta-catenin activation. We describe the role of C9orf140 in CRC progression and find that C9orf140 overexpression may be regulated by STAT5, EZH2 and beta-catenin interaction.

语种: 英语
所属项目编号: 81320108024 ; 91129724 ; 31271366 ; 20120073110078 ; 12QA1402000 ; 201268
项目资助者: National Natural Science Foundation ; Ministry of Education ; Shanghai Rising-Star Program ; Program for Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning
WOS记录号: WOS:000338647400021
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53318
Appears in Collections:北京大学临床肿瘤学院_分子肿瘤学研究室_期刊论文

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作者单位: 1.Shanghai Jiao Tong Univ, Sch Med, Shanghai Inst Digest Dis, Dept Gastroenterol & Hepatol,Renji Hosp, Shanghai 200030, Peoples R China
2.Minist Hlth, Key Lab Gastroenterol & Hepatol, Shanghai, Peoples R China
3.Rhode Isl Hosp, Providence, RI 02903 USA
4.Peking Univ, Sch Oncol, Beijing Inst Canc Res, Lab Mol Oncol, Beijing 100871, Peoples R China
5.Shanghai Jiao Tong Univ, Sch Med, State Key Lab Oncogenes & Related Genes, Shanghai Canc Inst,Renji Hosp, Shanghai 200030, Peoples R China
6.Brown Univ, Warren Alpert Med Sch, Dept Pathol & Med, Providence, RI 02903 USA

Recommended Citation:
Weng, Yu-Rong,Yu, Ya-Nan,Ren, Lin-Lin,et al. Role of C9orf140 in the promotion of colorectal cancer progression and mechanisms of its upregulation via activation of STAT5, beta-catenin and EZH2[J]. CARCINOGENESIS,2014,35(6):1389-1398.
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