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学科主题药学
Effect of TM208 an QGY-7703 xenograft tumor growth
Zhang, Ning1; Guo, Wei1; Wang, Li1; Huang, Wei1; Xu, Bo1; Ge, Zemei2; Li, Min1; Li, Run Tao2; Cui, Jing Rong1
关键词Cell Cycle Arrest Dithiocarbamate Extracellular Signal-regulated Kinase-1/2 Signal Pathway P38 Signal Pathway Qgy-7703
刊名ANTI-CANCER DRUGS
2008-07-01
19期:6页:593-598
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology ; Pharmacology & Pharmacy
研究领域[WOS]Oncology ; Pharmacology & Pharmacy
关键词[WOS]PROTEIN-KINASE-C ; CELL-CYCLE ; SIGNALING PATHWAY ; GENE-EXPRESSION ; RAS ; ACTIVATION ; TPA ; INHIBITION ; DITHIOCARBAMATE ; DERIVATIVES
英文摘要

A newly synthesized dithiocarbamate derivative, 4-methylpiperazine-1-carbodithioc-acid-3-cyano-3, 3-diphenylpropyl ester hydrochloride (TM208), has demonstrated anticancer effects with low toxicity in earlier studies; however, the mechanism has yet to be identified. We explored antitumor effects of TM208 and the possible mechanisms by which it inhibited the growth of human hepatocellular carcinoma cell line QGY-7703 xenograft tumors. Cell proliferation was evaluated with the sulforhodamine B assay in vitro. The results suggested that TM208 had slightly antiproliferative activity on QGY-7703 cells. The antitumor effect of TM208 was assessed in nude mice xenografted with QGY-7703 tumors. We found that TM208 significantly inhibited tumor growth but did not cause loss of body weight or leukocytopenia. Western blotting was used to detect the expression of protein kinase C alpha, mitogen-activated protein kinase signal pathways, and cell cycle-related proteins. The results showed that TM208 decreased the expression of protein kinase C alpha, phospho-extracellular signal-regulated kinase-1/2, phospho-p38, cyclin B1, cell division cycle 2 (cdc2), and phospho-cdc2 (Thr(161)) and increased the expression of phospho-cdc2 (Tyr(15)). Taken together, our data show that TM208 has little anti proliferative effect on QGY-7703 cells in vitro, whereas it significantly inhibits the growth of QGY-7703 xenograft tumors with low toxicity in vivo. The inhibition of mitogen-activated protein kinase signal pathways and the regulation of the G(2)/M phase may be responsible for its antitumor effects.

语种英语
WOS记录号WOS:000256721300005
引用统计
被引频次:11[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53320
专题北京大学临床肿瘤学院_肿瘤放疗科
北京大学药学院_天然药物与仿生药物国家重点实验室
北京大学药学院_化学生物学系
作者单位1.Peking Univ, Hlth Sci Ctr, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Dept Biol Chem, Sch Pharmaceut Sci, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Zhang, Ning,Guo, Wei,Wang, Li,et al. Effect of TM208 an QGY-7703 xenograft tumor growth[J]. ANTI-CANCER DRUGS,2008,19(6):593-598.
APA Zhang, Ning.,Guo, Wei.,Wang, Li.,Huang, Wei.,Xu, Bo.,...&Cui, Jing Rong.(2008).Effect of TM208 an QGY-7703 xenograft tumor growth.ANTI-CANCER DRUGS,19(6),593-598.
MLA Zhang, Ning,et al."Effect of TM208 an QGY-7703 xenograft tumor growth".ANTI-CANCER DRUGS 19.6(2008):593-598.
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