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学科主题: 药学
题名:
Effect of TM208 an QGY-7703 xenograft tumor growth
作者: Zhang, Ning1; Guo, Wei1; Wang, Li1; Huang, Wei1; Xu, Bo1; Ge, Zemei2; Li, Min1; Li, Run Tao2; Cui, Jing Rong1
关键词: cell cycle arrest ; dithiocarbamate ; extracellular signal-regulated kinase-1/2 signal pathway ; p38 signal pathway ; QGY-7703
刊名: ANTI-CANCER DRUGS
发表日期: 2008-07-01
卷: 19, 期:6, 页:593-598
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology ; Pharmacology & Pharmacy
研究领域[WOS]: Oncology ; Pharmacology & Pharmacy
关键词[WOS]: PROTEIN-KINASE-C ; CELL-CYCLE ; SIGNALING PATHWAY ; GENE-EXPRESSION ; RAS ; ACTIVATION ; TPA ; INHIBITION ; DITHIOCARBAMATE ; DERIVATIVES
英文摘要:

A newly synthesized dithiocarbamate derivative, 4-methylpiperazine-1-carbodithioc-acid-3-cyano-3, 3-diphenylpropyl ester hydrochloride (TM208), has demonstrated anticancer effects with low toxicity in earlier studies; however, the mechanism has yet to be identified. We explored antitumor effects of TM208 and the possible mechanisms by which it inhibited the growth of human hepatocellular carcinoma cell line QGY-7703 xenograft tumors. Cell proliferation was evaluated with the sulforhodamine B assay in vitro. The results suggested that TM208 had slightly antiproliferative activity on QGY-7703 cells. The antitumor effect of TM208 was assessed in nude mice xenografted with QGY-7703 tumors. We found that TM208 significantly inhibited tumor growth but did not cause loss of body weight or leukocytopenia. Western blotting was used to detect the expression of protein kinase C alpha, mitogen-activated protein kinase signal pathways, and cell cycle-related proteins. The results showed that TM208 decreased the expression of protein kinase C alpha, phospho-extracellular signal-regulated kinase-1/2, phospho-p38, cyclin B1, cell division cycle 2 (cdc2), and phospho-cdc2 (Thr(161)) and increased the expression of phospho-cdc2 (Tyr(15)). Taken together, our data show that TM208 has little anti proliferative effect on QGY-7703 cells in vitro, whereas it significantly inhibits the growth of QGY-7703 xenograft tumors with low toxicity in vivo. The inhibition of mitogen-activated protein kinase signal pathways and the regulation of the G(2)/M phase may be responsible for its antitumor effects.

语种: 英语
WOS记录号: WOS:000256721300005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53320
Appears in Collections:北京大学药学院_化学生物学系_期刊论文

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作者单位: 1.Peking Univ, Hlth Sci Ctr, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Dept Biol Chem, Sch Pharmaceut Sci, Beijing 100083, Peoples R China

Recommended Citation:
Zhang, Ning,Guo, Wei,Wang, Li,et al. Effect of TM208 an QGY-7703 xenograft tumor growth[J]. ANTI-CANCER DRUGS,2008,19(6):593-598.
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