|Association of genetic predisposition to obesity with type 2 diabetes risk in Han Chinese individuals|
|Zhu, Jingwen1; Zong, Geng1; Lu, Ling1; Gan, Wei1; Ji, Linong2; Hu, Renming3; Ye, Xingwang1; Sun, Liang1; Loos, Ruth J. F.4; Li, Huaixing1; Lin, Xu1|
|关键词||Bmi Chinese Genetic Risk Score Homa-b Type 2 Diabetes|
|WOS标题词||Science & Technology|
|类目[WOS]||Endocrinology & Metabolism|
|研究领域[WOS]||Endocrinology & Metabolism|
|关键词[WOS]||BODY-MASS INDEX ; COMMON VARIANTS ; LOCI|
Aims/hypothesis Obesity is a major risk factor for type 2 diabetes, but little is known about the contribution of BMI-associated loci to type 2 diabetes risk in East Asian populations.
Methods In this study, 30 known BMI-associated variants and a genetic risk score (GRS) calculated by summing the BMI-increasing alleles of these variants were tested for associations with type 2 diabetes and related glycaemic traits in 1,873 cases of type 2 diabetes and 1,839 controls in Han Chinese individuals. Logistic and linear regression analyses were performed to determine the association with type 2 diabetes risk or related glycaemic traits, respectively, under an additive model with or without adjustment for BMI.
Results The GRS was significantly associated with increased BMI (beta [SE] 0.070 [0.016]; p = 1.33 x 10(-5)) in the overall population. Each additional BMI-increasing allele in the GRS increased type 2 diabetes risk by 1.029-fold (95% CI 1.008, 1.050; p = 0.0056) without adjustment for BMI, and the association was slightly attenuated after adjustment for BMI (OR 1.022; 95% CI 1.002, 1.043; p = 0.035). In non-diabetic controls, the GRS was also associated with HOMA of beta cell function (HOMA-B) with adjustment for BMI (beta [SE] -0.876 [0.345]; p = 0.011). Notably, the association of GRS with type 2 diabetes was abolished after adjusting for HOMA-B (OR 1.012; 95% CI 0.986, 1.039; p = 0.380).
Conclusions/interpretation Our results suggested that genetic predisposition to obesity leads to increased risk of type 2 diabetes, independent of BMI and partly through impaired beta cell function.
|项目编号||2012CB524900 ; 30930081 ; 81321062 ; 81170734 ; 81200581 ; 2013KIP107|
|资助机构||Ministry of Science and Technology of China (973 Program) ; National Natural Science Foundation of China ; Knowledge Innovation Program of Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences ; SA-SIBS Scholarship Program|
|作者单位||1.Univ Chinese Acad Sci, Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutrit Sci,Key Lab Nutr & Metab, Shanghai 200031, Peoples R China|
2.Peking Univ, Peoples Hosp, Dept Endocrinol & Metab, Beijing 100871, Peoples R China
3.Fudan Univ, Shanghai Med Coll, Huashan Hosp, Inst Endocrinol & Diabetol, Shanghai, Peoples R China
4.Mt Sinai Sch Med, Inst Child Hlth & Dev, Charles Bronfman Inst Personalized Med, Dept Prevent Med,Genet Obesity & Related Traits P, York, NY USA
|Zhu, Jingwen,Zong, Geng,Lu, Ling,et al. Association of genetic predisposition to obesity with type 2 diabetes risk in Han Chinese individuals[J]. DIABETOLOGIA,2014,57(9):1830-1833.|
|APA||Zhu, Jingwen.,Zong, Geng.,Lu, Ling.,Gan, Wei.,Ji, Linong.,...&Lin, Xu.(2014).Association of genetic predisposition to obesity with type 2 diabetes risk in Han Chinese individuals.DIABETOLOGIA,57(9),1830-1833.|
|MLA||Zhu, Jingwen,et al."Association of genetic predisposition to obesity with type 2 diabetes risk in Han Chinese individuals".DIABETOLOGIA 57.9(2014):1830-1833.|