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学科主题: 公共卫生
题名:
Prevention of retinoic acid-induced early craniofacial abnormalities by folinic acid and expression of endothelin-1/dHAND in the branchial arches in mouse
作者: Zhang, Zhaofeng; Xu, Yajun; Li, Li; Han, Jing; Zheng, Liping; Liu, Peng; Li, Yong
关键词: branchial arch ; dHAND ; endothelin-1 ; folinic acid ; whole embryo culture
刊名: BRITISH JOURNAL OF NUTRITION
发表日期: 2006-09-01
DOI: 10.1079/BJN20061854
卷: 96, 期:3, 页:418-425
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Nutrition & Dietetics
研究领域[WOS]: Nutrition & Dietetics
关键词[WOS]: NEURAL-TUBE DEFECTS ; CASCADE INVOLVING ENDOTHELIN-1 ; GENE-EXPRESSION ; EMBRYO CULTURE ; CHICK-EMBRYO ; CREST CELLS ; A RECEPTOR ; INNER-EAR ; VITAMIN-A ; MICE
英文摘要:

Prevention of retinoic acid-induced craniofacial abnormalities by folinic acid, and endothelin-1 (ET-1)/dHAND protein and mRNA expression were investigated in mouse embryos using the whole embryo culture, streptavidin-biotin peroxidase complex method, and whole-mount in situ hybridization. In the whole embryo culture, 1.0 and 0.1 mM-folinic acid dose dependently prevented branchial region malformations and decreased defects by 93 % and 77 %, respectively. Folinic acid at concentrations of 1.0 and 0.1 mm significantly increased ET-1 and dHAND protein expression levels compared to retinoic acid-exposed values in embryonic branchial areas. Folinic acid also increased ET-1 and dHAND mRNA levels in the same region. The present results suggest that folinic acid may prevent retinoic acid-induced craniofacial abnormalities via increasing ET-1 and dHAND levels in the branchial region during the organogenic period.

语种: 英语
WOS记录号: WOS:000239971800002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53324
Appears in Collections:北京大学公共卫生学院_期刊论文

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作者单位: Peking Univ, Sch Publ Hlth, Lab Mol Toxicol & Dev Mol Biol, Dept Nutr & Food Hyg, Beijing 100083, Peoples R China

Recommended Citation:
Zhang, Zhaofeng,Xu, Yajun,Li, Li,et al. Prevention of retinoic acid-induced early craniofacial abnormalities by folinic acid and expression of endothelin-1/dHAND in the branchial arches in mouse[J]. BRITISH JOURNAL OF NUTRITION,2006,96(3):418-425.
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