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Prevention of retinoic acid-induced early craniofacial abnormalities by folinic acid and expression of endothelin-1/dHAND in the branchial arches in mouse
Zhang, Zhaofeng; Xu, Yajun; Li, Li; Han, Jing; Zheng, Liping; Liu, Peng; Li, Yong
关键词Branchial Arch Dhand Endothelin-1 Folinic Acid Whole Embryo Culture
刊名BRITISH JOURNAL OF NUTRITION
2006-09-01
DOI10.1079/BJN20061854
96期:3页:418-425
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Nutrition & Dietetics
研究领域[WOS]Nutrition & Dietetics
关键词[WOS]NEURAL-TUBE DEFECTS ; CASCADE INVOLVING ENDOTHELIN-1 ; GENE-EXPRESSION ; EMBRYO CULTURE ; CHICK-EMBRYO ; CREST CELLS ; A RECEPTOR ; INNER-EAR ; VITAMIN-A ; MICE
英文摘要

Prevention of retinoic acid-induced craniofacial abnormalities by folinic acid, and endothelin-1 (ET-1)/dHAND protein and mRNA expression were investigated in mouse embryos using the whole embryo culture, streptavidin-biotin peroxidase complex method, and whole-mount in situ hybridization. In the whole embryo culture, 1.0 and 0.1 mM-folinic acid dose dependently prevented branchial region malformations and decreased defects by 93 % and 77 %, respectively. Folinic acid at concentrations of 1.0 and 0.1 mm significantly increased ET-1 and dHAND protein expression levels compared to retinoic acid-exposed values in embryonic branchial areas. Folinic acid also increased ET-1 and dHAND mRNA levels in the same region. The present results suggest that folinic acid may prevent retinoic acid-induced craniofacial abnormalities via increasing ET-1 and dHAND levels in the branchial region during the organogenic period.

语种英语
WOS记录号WOS:000239971800002
引用统计
被引频次:10[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53324
专题北京大学公共卫生学院
北京大学公共卫生学院_营养与食品卫生学系
作者单位Peking Univ, Sch Publ Hlth, Lab Mol Toxicol & Dev Mol Biol, Dept Nutr & Food Hyg, Beijing 100083, Peoples R China
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GB/T 7714
Zhang, Zhaofeng,Xu, Yajun,Li, Li,et al. Prevention of retinoic acid-induced early craniofacial abnormalities by folinic acid and expression of endothelin-1/dHAND in the branchial arches in mouse[J]. BRITISH JOURNAL OF NUTRITION,2006,96(3):418-425.
APA Zhang, Zhaofeng.,Xu, Yajun.,Li, Li.,Han, Jing.,Zheng, Liping.,...&Li, Yong.(2006).Prevention of retinoic acid-induced early craniofacial abnormalities by folinic acid and expression of endothelin-1/dHAND in the branchial arches in mouse.BRITISH JOURNAL OF NUTRITION,96(3),418-425.
MLA Zhang, Zhaofeng,et al."Prevention of retinoic acid-induced early craniofacial abnormalities by folinic acid and expression of endothelin-1/dHAND in the branchial arches in mouse".BRITISH JOURNAL OF NUTRITION 96.3(2006):418-425.
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