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Study of a possible role of the monoamine oxidase A (MAOA) gene in paranoid schizophrenia among a Chinese population
Sun, Yuhui1,2; Zhang, Jiexu1,2; Yuan, Yanbo3; Yu, Xin3; Shen, Yan1,2; Xu, Qi1,2
关键词Maoa Gene Paranoid Schizophrenia Haplotype Mrna Expression
刊名AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
2012
DOI10.1002/ajmg.b.32009
159B期:1页:104-111
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Genetics & Heredity ; Psychiatry
资助者National Basic Research Program of China ; National Natural Science Foundation of China ; Beijing Natural Science Foundation ; Fok Ying Tong Education Foundation ; National Basic Research Program of China ; National Natural Science Foundation of China ; Beijing Natural Science Foundation ; Fok Ying Tong Education Foundation
研究领域[WOS]Genetics & Heredity ; Psychiatry
关键词[WOS]DOPAMINE-SEROTONIN HYPOTHESIS ; A GENE ; ASSOCIATION ANALYSIS ; ALLELIC VARIATION ; PANIC DISORDER ; PROMOTER ; POLYMORPHISMS ; PATHOPHYSIOLOGY ; LOCALIZATION ; EXPRESSION
英文摘要

Monoamine oxidase A (MAOA) is the enzyme responsible for degradation of several monoamines, such as dopamine and serotonin that are considered as being two of the most important neurotransmitters involved in the pathophysiology of schizophrenia. To study a possible role of the MAOA gene in conferring susceptibility to schizophrenia, the present study genotyped the variable number of tandem repeat (VNTR) polymorphism and 41 SNPs across this gene among 555 unrelated patients with paranoid schizophrenia and 567 unrelated healthy controls. Quantitative real-time PCR analysis was employed to quantify expression of MAOA mRNA in 73 drug-free patients. While none of these genotyped DNA markers showed allelic association with paranoid schizophrenia, haplotypic association was found for the VNTR-rs6323, VNTR-rs1137070, and VNTR-rs6323-rs1137070 haplotypes in female subjects. Nevertheless, no significant change of the expression of MAOA mRNA was detected in either female or male patients with paranoid schizophrenia. Our study suggests that the interaction between genetic variants within the MAOA gene may contribute to an increased risk of paranoid schizophrenia, but the precise mechanism needs further investigation. (C) 2011 Wiley Periodicals, Inc.

语种英语
所属项目编号2010CB529603 ; 2012CB517902 ; 30971001 ; 31021091 ; 7102109 ; 121024
资助者National Basic Research Program of China ; National Natural Science Foundation of China ; Beijing Natural Science Foundation ; Fok Ying Tong Education Foundation ; National Basic Research Program of China ; National Natural Science Foundation of China ; Beijing Natural Science Foundation ; Fok Ying Tong Education Foundation
WOS记录号WOS:000298536800014
Citation statistics
Cited Times:9[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53326
Collection北京大学精神卫生研究所
作者单位1.Peking Univ, Inst Mental Hlth, Beijing 100871, Peoples R China
2.Tsinghua Univ, Natl Lab Med Mol Biol, Inst Basic Med Sci, Chinese Acad Med Sci,Sch Basic Med, Beijing 100005, Peoples R China
3.Tsinghua Univ, Peking Union Med Coll, Beijing 100005, Peoples R China
Recommended Citation
GB/T 7714
Sun, Yuhui,Zhang, Jiexu,Yuan, Yanbo,et al. Study of a possible role of the monoamine oxidase A (MAOA) gene in paranoid schizophrenia among a Chinese population[J]. AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS,2012,159B(1):104-111.
APA Sun, Yuhui,Zhang, Jiexu,Yuan, Yanbo,Yu, Xin,Shen, Yan,&Xu, Qi.(2012).Study of a possible role of the monoamine oxidase A (MAOA) gene in paranoid schizophrenia among a Chinese population.AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS,159B(1),104-111.
MLA Sun, Yuhui,et al."Study of a possible role of the monoamine oxidase A (MAOA) gene in paranoid schizophrenia among a Chinese population".AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS 159B.1(2012):104-111.
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