IR@PKUHSC  > 北京大学公共卫生学院
学科主题公共卫生
Milk inhibits the regression of 7,12-dimethylbenz(a)anthracene-induced mammary tumors in ovariectomized rats
Qin, Li-Qiang1,2; Xu, Jia-Ying1; Tezuka, Hideo3; Wang, Pei-Yu4; Hoshi, Kazuhiko2
刊名NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
2008-07-01
DOI10.1080/01635580801927452
60期:4页:505-510
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology ; Nutrition & Dietetics
研究领域[WOS]Oncology ; Nutrition & Dietetics
关键词[WOS]GROWTH-FACTOR-I ; BREAST EPITHELIAL-CELLS ; CANCER RISK ; IGF-I ; CALCIUM ; SERUM ; CONSUMPTION ; ESTROGENS ; PRODUCTS ; HORMONES
英文摘要

Epidemiological studies have yielded inconsistent results regarding the relation between the milk consumption and breast cancer risk. In this study, rats were induced mammary tumors by 7,12-dimethylbenz(a)anthracene. When tumors developed to acceptable levels, rats were placed into I of 3 treatment groups. Those in the negative control group and the milk group were ovariectomized, whereas those in the positive control group were sham operated. After grouping, tumor incidence remained 100%, and tumor number and volume increased in the positive control group. However, tumors in the 2 ovariectomized groups regressed. Compared with the negative control group, tumor incidence and tumor number and volume per rat in the milk group became significantly higher from Week 6 and Week 4, respectively. Insulin-like growth factor-I levels were borderline significantly higher in the milk group than in the negative control group at autopsy. Although plasma 17 beta-estradiol levels did not differ significantly, estrogenicity was found in the milk group because uterine weight was significantly heavier in the milk group than in the negative control group. In conclusion, commercial milk inhibited the regression of carcinogen-induced mammary tumors in ovariectomized rats.

语种英语
WOS记录号WOS:000257988700009
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53329
专题北京大学公共卫生学院
北京大学药学院_药剂学系
作者单位1.Univ Yamanashi, Ctr Life Sci Res, Yamanashi, Japan
2.Soochow Univ, Sch Radiat Med & Publ Hlth, Suzhou 215123, Peoples R China
3.Univ Yamanashi, Sch Med, Dept Obstet & Gynecol, Yamanashi, Japan
4.Peking Univ, Sch Publ Hlth, Dept Social Med & Hlth Educ, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Qin, Li-Qiang,Xu, Jia-Ying,Tezuka, Hideo,et al. Milk inhibits the regression of 7,12-dimethylbenz(a)anthracene-induced mammary tumors in ovariectomized rats[J]. NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL,2008,60(4):505-510.
APA Qin, Li-Qiang,Xu, Jia-Ying,Tezuka, Hideo,Wang, Pei-Yu,&Hoshi, Kazuhiko.(2008).Milk inhibits the regression of 7,12-dimethylbenz(a)anthracene-induced mammary tumors in ovariectomized rats.NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL,60(4),505-510.
MLA Qin, Li-Qiang,et al."Milk inhibits the regression of 7,12-dimethylbenz(a)anthracene-induced mammary tumors in ovariectomized rats".NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL 60.4(2008):505-510.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Qin, Li-Qiang]的文章
[Xu, Jia-Ying]的文章
[Tezuka, Hideo]的文章
百度学术
百度学术中相似的文章
[Qin, Li-Qiang]的文章
[Xu, Jia-Ying]的文章
[Tezuka, Hideo]的文章
必应学术
必应学术中相似的文章
[Qin, Li-Qiang]的文章
[Xu, Jia-Ying]的文章
[Tezuka, Hideo]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。