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学科主题: 公共卫生
题名:
Milk inhibits the regression of 7,12-dimethylbenz(a)anthracene-induced mammary tumors in ovariectomized rats
作者: Qin, Li-Qiang1,2; Xu, Jia-Ying1; Tezuka, Hideo3; Wang, Pei-Yu4; Hoshi, Kazuhiko2
刊名: NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
发表日期: 2008-07-01
DOI: 10.1080/01635580801927452
卷: 60, 期:4, 页:505-510
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology ; Nutrition & Dietetics
研究领域[WOS]: Oncology ; Nutrition & Dietetics
关键词[WOS]: GROWTH-FACTOR-I ; BREAST EPITHELIAL-CELLS ; CANCER RISK ; IGF-I ; CALCIUM ; SERUM ; CONSUMPTION ; ESTROGENS ; PRODUCTS ; HORMONES
英文摘要:

Epidemiological studies have yielded inconsistent results regarding the relation between the milk consumption and breast cancer risk. In this study, rats were induced mammary tumors by 7,12-dimethylbenz(a)anthracene. When tumors developed to acceptable levels, rats were placed into I of 3 treatment groups. Those in the negative control group and the milk group were ovariectomized, whereas those in the positive control group were sham operated. After grouping, tumor incidence remained 100%, and tumor number and volume increased in the positive control group. However, tumors in the 2 ovariectomized groups regressed. Compared with the negative control group, tumor incidence and tumor number and volume per rat in the milk group became significantly higher from Week 6 and Week 4, respectively. Insulin-like growth factor-I levels were borderline significantly higher in the milk group than in the negative control group at autopsy. Although plasma 17 beta-estradiol levels did not differ significantly, estrogenicity was found in the milk group because uterine weight was significantly heavier in the milk group than in the negative control group. In conclusion, commercial milk inhibited the regression of carcinogen-induced mammary tumors in ovariectomized rats.

语种: 英语
WOS记录号: WOS:000257988700009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53329
Appears in Collections:北京大学公共卫生学院_期刊论文

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作者单位: 1.Univ Yamanashi, Ctr Life Sci Res, Yamanashi, Japan
2.Soochow Univ, Sch Radiat Med & Publ Hlth, Suzhou 215123, Peoples R China
3.Univ Yamanashi, Sch Med, Dept Obstet & Gynecol, Yamanashi, Japan
4.Peking Univ, Sch Publ Hlth, Dept Social Med & Hlth Educ, Beijing, Peoples R China

Recommended Citation:
Qin, Li-Qiang,Xu, Jia-Ying,Tezuka, Hideo,et al. Milk inhibits the regression of 7,12-dimethylbenz(a)anthracene-induced mammary tumors in ovariectomized rats[J]. NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL,2008,60(4):505-510.
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