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学科主题基础医学
Effects of cardiotonic pill on RBC rheologic abnormalities in HFD-induced mice and LPL deficient mice
Wang, Xian-Wei1; Guo, Jun1; Wang, Xi-Fu2; Chen, Xiao-Peng1; Wen, Zong-Yao1
关键词Cardiotonic pill hypertriglyceridemia LPL deficient mice rheologic property
刊名CLINICAL HEMORHEOLOGY AND MICROCIRCULATION
2008
DOI10.3233/CH-2008-1138
40期:4页:281-288
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Hematology ; Peripheral Vascular Disease
研究领域[WOS]Hematology ; Cardiovascular System & Cardiology
关键词[WOS]RED-BLOOD-CELLS ; SHEAR-FLOW FIELD ; HIGH-FAT DIET ; SALVIA-MILTIORRHIZA ; SEVERE HYPERTRIGLYCERIDEMIA ; HEMORHEOLOGICAL PARAMETERS ; ERYTHROCYTE DEFORMABILITY ; LOW-VISCOSITY ; ATHEROSCLEROSIS ; PLASMA
英文摘要

The lipoprotein lipase deficient (LPL-/-) mice and high fat-diet (HFD) induced hypertriglyceridemic mice were used to investigate the effects of cardiotonic pill (CP) on RBC rheologic abnormalities. Mice were randomly divided into the following five groups: the control group; the untreated HFD group; the untreated LPL-/- group; the treated HFD group; and the treated LPL-/- group, and the treated HFD and LPL-/- mice were administered with CP twice a day (400 mg/kg/day) orally for four weeks. Then, plasma triglyceride (TG), RBC deformation index (DI), orientation index (DI) or and RBC electrophoretic time (EPT) were measured. Compared with the untreated HFD mice, TG level and EPT reduced and DI and (DI) or increased markedly in the treated HFD mice (P < 0.05). However, compared with the untreated LPL-/- mice, these parameters in the treated LPL-/- mice had no statistically significant changes (P > 0.05). Our data show that CP can lower plasma TG level and ameliorate RBC rheologic abnormalities in the HFD-induced hypertriglyceridemic mice, but it losses its capacity in the LPL deficient animals. The results indicate that LPL may be one of the important targets for CP regulating lipometabolism and rheologic abnormalities.

语种英语
WOS记录号WOS:000262875500004
项目编号10572007 ; 30770532
资助机构National Natural Science Foundations of China
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53332
专题北京大学基础医学院_生物物理学系
北京大学临床肿瘤学院_肾癌黑色素瘤内科
作者单位1.Peking Univ, Dept Biophys, Hlth Sci Ctr, Beijing 100083, Peoples R China
2.Peking Univ, Res Ctr Occut Med, Hosp 3, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Wang, Xian-Wei,Guo, Jun,Wang, Xi-Fu,et al. Effects of cardiotonic pill on RBC rheologic abnormalities in HFD-induced mice and LPL deficient mice[J]. CLINICAL HEMORHEOLOGY AND MICROCIRCULATION,2008,40(4):281-288.
APA Wang, Xian-Wei,Guo, Jun,Wang, Xi-Fu,Chen, Xiao-Peng,&Wen, Zong-Yao.(2008).Effects of cardiotonic pill on RBC rheologic abnormalities in HFD-induced mice and LPL deficient mice.CLINICAL HEMORHEOLOGY AND MICROCIRCULATION,40(4),281-288.
MLA Wang, Xian-Wei,et al."Effects of cardiotonic pill on RBC rheologic abnormalities in HFD-induced mice and LPL deficient mice".CLINICAL HEMORHEOLOGY AND MICROCIRCULATION 40.4(2008):281-288.
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