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学科主题: 基础医学
题名:
Effects of cardiotonic pill on RBC rheologic abnormalities in HFD-induced mice and LPL deficient mice
作者: Wang, Xian-Wei1; Guo, Jun1; Wang, Xi-Fu2; Chen, Xiao-Peng1; Wen, Zong-Yao1
关键词: Cardiotonic pill ; hypertriglyceridemia ; LPL deficient mice ; rheologic property
刊名: CLINICAL HEMORHEOLOGY AND MICROCIRCULATION
发表日期: 2008
DOI: 10.3233/CH-2008-1138
卷: 40, 期:4, 页:281-288
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Hematology ; Peripheral Vascular Disease
研究领域[WOS]: Hematology ; Cardiovascular System & Cardiology
关键词[WOS]: RED-BLOOD-CELLS ; SHEAR-FLOW FIELD ; HIGH-FAT DIET ; SALVIA-MILTIORRHIZA ; SEVERE HYPERTRIGLYCERIDEMIA ; HEMORHEOLOGICAL PARAMETERS ; ERYTHROCYTE DEFORMABILITY ; LOW-VISCOSITY ; ATHEROSCLEROSIS ; PLASMA
英文摘要:

The lipoprotein lipase deficient (LPL-/-) mice and high fat-diet (HFD) induced hypertriglyceridemic mice were used to investigate the effects of cardiotonic pill (CP) on RBC rheologic abnormalities. Mice were randomly divided into the following five groups: the control group; the untreated HFD group; the untreated LPL-/- group; the treated HFD group; and the treated LPL-/- group, and the treated HFD and LPL-/- mice were administered with CP twice a day (400 mg/kg/day) orally for four weeks. Then, plasma triglyceride (TG), RBC deformation index (DI), orientation index (DI) or and RBC electrophoretic time (EPT) were measured. Compared with the untreated HFD mice, TG level and EPT reduced and DI and (DI) or increased markedly in the treated HFD mice (P < 0.05). However, compared with the untreated LPL-/- mice, these parameters in the treated LPL-/- mice had no statistically significant changes (P > 0.05). Our data show that CP can lower plasma TG level and ameliorate RBC rheologic abnormalities in the HFD-induced hypertriglyceridemic mice, but it losses its capacity in the LPL deficient animals. The results indicate that LPL may be one of the important targets for CP regulating lipometabolism and rheologic abnormalities.

语种: 英语
所属项目编号: 10572007 ; 30770532
项目资助者: National Natural Science Foundations of China
WOS记录号: WOS:000262875500004
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53332
Appears in Collections:基础医学院_生物物理学系_期刊论文

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作者单位: 1.Peking Univ, Dept Biophys, Hlth Sci Ctr, Beijing 100083, Peoples R China
2.Peking Univ, Res Ctr Occut Med, Hosp 3, Beijing 100083, Peoples R China

Recommended Citation:
Wang, Xian-Wei,Guo, Jun,Wang, Xi-Fu,et al. Effects of cardiotonic pill on RBC rheologic abnormalities in HFD-induced mice and LPL deficient mice[J]. CLINICAL HEMORHEOLOGY AND MICROCIRCULATION,2008,40(4):281-288.
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