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Is serum cystatin C an early predictor for acute kidney injury following cardiopulmonary bypass surgery in infants and young children?
Zheng, Jian-Yong1; Xiao, Yan-Yan1; Yao, Yong2; Han, Ling1
关键词Acute Kidney Injury Cardiopulmonary Bypass Surgery Cystatin c Infants And Young Children
刊名KAOHSIUNG JOURNAL OF MEDICAL SCIENCES
2013-09-01
DOI10.1016/j.kjms.2013.01.004
29期:9页:494-499
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, Research & Experimental
研究领域[WOS]Research & Experimental Medicine
关键词[WOS]CONGENITAL HEART-DISEASE ; ACUTE-RENAL-FAILURE ; CARDIAC-SURGERY ; RISK ; BIOMARKER ; DIALYSIS
英文摘要

Acute kidney injury (AKI) is a potential complication following cardiopulmonary bypass (CPB) surgery in infants and young children with congenital heart disease (CHD). The current pilot study evaluates the predictive value of serum cystatin C (CysC) for AKI after pediatric CPB surgery. We prospectively enrolled 43 children with CHD (30 males and 13 females) who underwent CPB surgery. They were aged 3 years or younger. Serum CysC was measured at baseline and at 6 hours, 12 hours, 24 hours, and 48 hours after initiating CBP. Twenty-one (48.8%) patients developed AKI after cardiac surgery. Children who developed AKI had more complex cardiac surgical procedures (based on the Risk Adjustment for Congenital Heart Surgery 1 [RACHS-1] category), a longer CPB duration, and a longer aortic clamping time (ACT). Serum concentrations of CysC postoperatively demonstrated an initial decline at 6 hours, a subsequent increase at 12 hours, and stabilized at 24-48 hours. The best predictive performance was achieved 6 hours after CPB with an area under receiver operating characteristic curve (AUC) value of 0.69. The optimal cut-off value was 0.47 mg/L (sensitivity, 85.7%; specificity, 50%). By contrast, the RACHS-1 category, CPB duration, and ACT had higher AUC values at 0.735, 0.791, and 0.731, respectively. In conclusion, serum CysC had limited predictive capacity and was not superior to clinical risk factors for the early detection of AKI after CPB surgery in this pilot study, which focused on infants and young children. Copyright (C) 2013, Kaohsiung Medical University. Published by Elsevier Taiwan LLC. All rights reserved.

语种英语
WOS记录号WOS:000324305900005
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53333
专题北京大学第一临床医学院
北京大学第一临床医学院_儿科
作者单位1.Capital Med Univ, Beijing Anzhen Hosp, Dept Pediat Cardiol & Cardiac Surg, Beijing, Peoples R China
2.Peking Univ, Hosp 1, Dept Pediat Nephrol, Beijing 100871, Peoples R China
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GB/T 7714
Zheng, Jian-Yong,Xiao, Yan-Yan,Yao, Yong,et al. Is serum cystatin C an early predictor for acute kidney injury following cardiopulmonary bypass surgery in infants and young children?[J]. KAOHSIUNG JOURNAL OF MEDICAL SCIENCES,2013,29(9):494-499.
APA Zheng, Jian-Yong,Xiao, Yan-Yan,Yao, Yong,&Han, Ling.(2013).Is serum cystatin C an early predictor for acute kidney injury following cardiopulmonary bypass surgery in infants and young children?.KAOHSIUNG JOURNAL OF MEDICAL SCIENCES,29(9),494-499.
MLA Zheng, Jian-Yong,et al."Is serum cystatin C an early predictor for acute kidney injury following cardiopulmonary bypass surgery in infants and young children?".KAOHSIUNG JOURNAL OF MEDICAL SCIENCES 29.9(2013):494-499.
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