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学科主题: 临床医学
题名:
Is serum cystatin C an early predictor for acute kidney injury following cardiopulmonary bypass surgery in infants and young children?
作者: Zheng, Jian-Yong1; Xiao, Yan-Yan1; Yao, Yong2; Han, Ling1
关键词: Acute kidney injury ; Cardiopulmonary bypass surgery ; Cystatin C ; Infants and young children
刊名: KAOHSIUNG JOURNAL OF MEDICAL SCIENCES
发表日期: 2013-09-01
DOI: 10.1016/j.kjms.2013.01.004
卷: 29, 期:9, 页:494-499
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, Research & Experimental
研究领域[WOS]: Research & Experimental Medicine
关键词[WOS]: CONGENITAL HEART-DISEASE ; ACUTE-RENAL-FAILURE ; CARDIAC-SURGERY ; RISK ; BIOMARKER ; DIALYSIS
英文摘要:

Acute kidney injury (AKI) is a potential complication following cardiopulmonary bypass (CPB) surgery in infants and young children with congenital heart disease (CHD). The current pilot study evaluates the predictive value of serum cystatin C (CysC) for AKI after pediatric CPB surgery. We prospectively enrolled 43 children with CHD (30 males and 13 females) who underwent CPB surgery. They were aged 3 years or younger. Serum CysC was measured at baseline and at 6 hours, 12 hours, 24 hours, and 48 hours after initiating CBP. Twenty-one (48.8%) patients developed AKI after cardiac surgery. Children who developed AKI had more complex cardiac surgical procedures (based on the Risk Adjustment for Congenital Heart Surgery 1 [RACHS-1] category), a longer CPB duration, and a longer aortic clamping time (ACT). Serum concentrations of CysC postoperatively demonstrated an initial decline at 6 hours, a subsequent increase at 12 hours, and stabilized at 24-48 hours. The best predictive performance was achieved 6 hours after CPB with an area under receiver operating characteristic curve (AUC) value of 0.69. The optimal cut-off value was 0.47 mg/L (sensitivity, 85.7%; specificity, 50%). By contrast, the RACHS-1 category, CPB duration, and ACT had higher AUC values at 0.735, 0.791, and 0.731, respectively. In conclusion, serum CysC had limited predictive capacity and was not superior to clinical risk factors for the early detection of AKI after CPB surgery in this pilot study, which focused on infants and young children. Copyright (C) 2013, Kaohsiung Medical University. Published by Elsevier Taiwan LLC. All rights reserved.

语种: 英语
WOS记录号: WOS:000324305900005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53333
Appears in Collections:北京大学第一临床医学院_期刊论文

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作者单位: 1.Capital Med Univ, Beijing Anzhen Hosp, Dept Pediat Cardiol & Cardiac Surg, Beijing, Peoples R China
2.Peking Univ, Hosp 1, Dept Pediat Nephrol, Beijing 100871, Peoples R China

Recommended Citation:
Zheng, Jian-Yong,Xiao, Yan-Yan,Yao, Yong,et al. Is serum cystatin C an early predictor for acute kidney injury following cardiopulmonary bypass surgery in infants and young children?[J]. KAOHSIUNG JOURNAL OF MEDICAL SCIENCES,2013,29(9):494-499.
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