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A pilot trial on the molecular pathophysiology of traumatic temporomandibular joint bony ankylosis in a sheep model. Part II: The differential gene expression among fibrous ankylosis, bony ankylosis and condylar fracture
Yan, Ying-Bin1,4; Li, Jiang-Ming1; Xiao, E.1; An, Jin-Gang1; Gan, Ye-Hua2,3; Zhang, Yi1
关键词Temporomandibular Joint Ankylosis Trauma Animal Model Gene Expression Sheep
刊名JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY
2014-03-01
DOI10.1016/j.jcms.2013.04.008
42期:2页:E23-E28
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Dentistry, Oral Surgery & Medicine ; Surgery
研究领域[WOS]Dentistry, Oral Surgery & Medicine ; Surgery
关键词[WOS]REDUCES OSTEOCYTE EXPRESSION ; MECHANICAL STIMULATION ; 2003 UPDATE ; NONUNION
英文摘要

Objective: The purpose of the study was to preliminarily explore the differential expressions of a series of genes regulating bone formation in temporomandibular joint (TMJ) fibrous ankylosis, bony ankylosis and condylar fracture healing.

Methods: The cDNA from either the bony ankylosed callus or fracture callus of the 6 sheep, as described in the part I, were both used in the study. The differences of gene expressions between bony ankylosis and condylar fracture at 1, 3, and 6 months postoperatively were measured by real-time PCR, with 2 samples at each time point. In addition, another 2 sheep were added to have fibrous ankylosis induced on the right TMJ, and 1 sheep was sacrificed at 3 and 6 months after surgery, respectively. The differences of gene expressions between fibrous and bony ankylosis at 3 and 6 months postoperatively were measured by real-time PCR.

Results: Bony ankylosis showed higher mRNA expression trends in Wnt2b, Wnt5a, beta-Catenin, Lef1, CyclinD1, Runx2, Osterix, Sox9, Col10a1, Alp, Ocn, Bmp2, and Bmp7 compared to fibrous ankylosis, although no statistical analysis was performed due to the very small sample size. Whereas bony ankylosis showed a significant lower expression of Wnt5a, beta-Catenin, Lef1, Runx2, Osterix, Sox9, Col10a1, Alp, Ocn and Bmp4 compared to condylar fracture at several time points (P < 0.05).

Conclusion: Our data provided a preliminary molecular evidence for the hypothesis that the development of traumatic TMJ bony ankylosis was the course of delayed bone healing or hypertrophic nonunion, and deserved to be further studied. (C) 2013 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000346971700002
项目编号81070808 ; 81170936
资助机构National Natural Science Foundation of China
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53337
专题北京大学口腔医学院
北京大学口腔医学院_外科
北京大学口腔医学院_中心实验室
作者单位1.Peking Univ Sch & Hosp Stomatol, Dept Oral & Maxillofacial Surg, Beijing 100081, Peoples R China
2.Peking Univ Sch & Hosp Stomatol, Mol Biol Lab, Beijing 100081, Peoples R China
3.Peking Univ Sch & Hosp Stomatol, Ctr Temporomandibular Disorders & Orofacial Pain, Beijing 100081, Peoples R China
4.Tianjin Stomatol Hosp, Dept Oral & Maxillofacial Surg, Tianjin 300041, Peoples R China
推荐引用方式
GB/T 7714
Yan, Ying-Bin,Li, Jiang-Ming,Xiao, E.,et al. A pilot trial on the molecular pathophysiology of traumatic temporomandibular joint bony ankylosis in a sheep model. Part II: The differential gene expression among fibrous ankylosis, bony ankylosis and condylar fracture[J]. JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY,2014,42(2):E23-E28.
APA Yan, Ying-Bin,Li, Jiang-Ming,Xiao, E.,An, Jin-Gang,Gan, Ye-Hua,&Zhang, Yi.(2014).A pilot trial on the molecular pathophysiology of traumatic temporomandibular joint bony ankylosis in a sheep model. Part II: The differential gene expression among fibrous ankylosis, bony ankylosis and condylar fracture.JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY,42(2),E23-E28.
MLA Yan, Ying-Bin,et al."A pilot trial on the molecular pathophysiology of traumatic temporomandibular joint bony ankylosis in a sheep model. Part II: The differential gene expression among fibrous ankylosis, bony ankylosis and condylar fracture".JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY 42.2(2014):E23-E28.
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