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学科主题: 药学
题名:
Characterization of Chemical Constituents in Guan Xin II Decoction by Liquid Chromatography Coupled with Electrospray Ionization-Mass Spectrometry
作者: Qiao, Xue; Han, Jian; Xu, Man; Zhang, Zi-chuan; Sun, Shi-feng; Li, Hui-feng; Wang, Bao-rong; Ye, Min; Guo, De-an
关键词: chemical analysis ; Chinese medicine ; Guan Xin II decoction ; HPLC-DAD-ESI-MS(n)
刊名: PLANTA MEDICA
发表日期: 2008-11-01
DOI: 10.1055/s-0028-1088312
卷: 74, 期:14, 页:1720-1729
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]: Plant Sciences ; Pharmacology & Pharmacy
关键词[WOS]: FINGERPRINT ANALYSIS ; SALVIA-MILTIORRHIZA ; PEONY ROOT ; HPLC-MS ; ACID-B ; IDENTIFICATION ; PAEONIFLORIN ; METABOLITES ; LC
英文摘要:

Guan Xin II decoction (GX II) is a widely used traditional Chinese medicine (TCM) formula for the treatment of coronary heart diseases. However, the comprehensive chemical analysis of the formulated GX II is not clarified yet. An HPLC-DAD-ESI-MS(n) method was established to analyze GX II and its five component herbs, respectively. A total of 57 compounds, including phenolic acids, glycosides, flavonoids, and alkaloids were identified or tentatively characterized on the basis of their mass spectra or by comparison with reference standards. This is the first time that the chemical composition of GX II was elucidated by LC/MS. The established method will be used for quality control and pharmacokinetic studies of GX II.

语种: 英语
所属项目编号: 985-2-063-112 ; 104 218
项目资助者: Changjiang Scholars and Innovation Team in University ; Ministry of Education of China
WOS记录号: WOS:000261573500008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53338
Appears in Collections:北京大学药学院_期刊论文

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作者单位: Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China

Recommended Citation:
Qiao, Xue,Han, Jian,Xu, Man,et al. Characterization of Chemical Constituents in Guan Xin II Decoction by Liquid Chromatography Coupled with Electrospray Ionization-Mass Spectrometry[J]. PLANTA MEDICA,2008,74(14):1720-1729.
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