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Characterization of Chemical Constituents in Guan Xin II Decoction by Liquid Chromatography Coupled with Electrospray Ionization-Mass Spectrometry
Qiao, Xue; Han, Jian; Xu, Man; Zhang, Zi-chuan; Sun, Shi-feng; Li, Hui-feng; Wang, Bao-rong; Ye, Min; Guo, De-an
关键词Chemical Analysis Chinese Medicine Guan Xin Ii Decoction Hplc-dad-esi-ms(n)
刊名PLANTA MEDICA
2008-11-01
DOI10.1055/s-0028-1088312
74期:14页:1720-1729
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]Plant Sciences ; Pharmacology & Pharmacy
关键词[WOS]FINGERPRINT ANALYSIS ; SALVIA-MILTIORRHIZA ; PEONY ROOT ; HPLC-MS ; ACID-B ; IDENTIFICATION ; PAEONIFLORIN ; METABOLITES ; LC
英文摘要

Guan Xin II decoction (GX II) is a widely used traditional Chinese medicine (TCM) formula for the treatment of coronary heart diseases. However, the comprehensive chemical analysis of the formulated GX II is not clarified yet. An HPLC-DAD-ESI-MS(n) method was established to analyze GX II and its five component herbs, respectively. A total of 57 compounds, including phenolic acids, glycosides, flavonoids, and alkaloids were identified or tentatively characterized on the basis of their mass spectra or by comparison with reference standards. This is the first time that the chemical composition of GX II was elucidated by LC/MS. The established method will be used for quality control and pharmacokinetic studies of GX II.

语种英语
WOS记录号WOS:000261573500008
项目编号985-2-063-112 ; 104 218
资助机构Changjiang Scholars and Innovation Team in University ; Ministry of Education of China
引用统计
被引频次:10[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53338
专题北京大学药学院
北京大学药学院_天然药物学系
作者单位Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Qiao, Xue,Han, Jian,Xu, Man,et al. Characterization of Chemical Constituents in Guan Xin II Decoction by Liquid Chromatography Coupled with Electrospray Ionization-Mass Spectrometry[J]. PLANTA MEDICA,2008,74(14):1720-1729.
APA Qiao, Xue.,Han, Jian.,Xu, Man.,Zhang, Zi-chuan.,Sun, Shi-feng.,...&Guo, De-an.(2008).Characterization of Chemical Constituents in Guan Xin II Decoction by Liquid Chromatography Coupled with Electrospray Ionization-Mass Spectrometry.PLANTA MEDICA,74(14),1720-1729.
MLA Qiao, Xue,et al."Characterization of Chemical Constituents in Guan Xin II Decoction by Liquid Chromatography Coupled with Electrospray Ionization-Mass Spectrometry".PLANTA MEDICA 74.14(2008):1720-1729.
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