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学科主题: 精神卫生
题名:
Use of Anticholinergic Drugs in Patients with Schizophrenia in Asia from 2001 to 2009
作者: Xiang, Y. -T.1,2; Wang, C. -Y.2; Si, T. -M.3; Lee, E. H. M.1; He, Y. -L.4; Ungvari, G. S.5; Chiu, H. F. K.1; Yang, S-Y6; Chong, M. -Y.7,8; Tan, C. -H.9; Kua, E. -H.9; Fujii, S.10; Sim, K.11; Yong, K. H.11; Trivedi, J. K.12; Chung, E. -K.13; Udomratn, P.14; Chee, K. -Y.15; Sartorius, N.16; Shinfuku, N.17
刊名: PHARMACOPSYCHIATRY
发表日期: 2011-05-01
DOI: 10.1055/s-0031-1275658
卷: 44, 期:3, 页:114-118
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy ; Psychiatry
研究领域[WOS]: Pharmacology & Pharmacy ; Psychiatry
关键词[WOS]: CHINESE PATIENTS ; EAST-ASIA ; TARDIVE-DYSKINESIA ; ANTIPSYCHOTIC POLYPHARMACY ; SOCIAL DETERMINANTS ; PRESCRIPTION ; HALOPERIDOL ; MEDICATIONS ; IMPAIRMENT ; WITHDRAWAL
英文摘要:

Objective: The aim of this study was to survey the use of anticholinergic medication (ACM) in Asia between 2001 and 2009 and examine its demographic and clinical correlates.

Method: A total of 6761 hospitalized schizophrenia patients in 9 Asian countries and territories were examined between 2001 and 2009. The patients′ socio-demographic and clinical characteristics and the prescriptions of psychotropic drugs were recorded using a standardized protocol and data collection procedure.

Results: The frequency of ACM prescription decreased from 66.3% in 2001, to 52.8% in 2004 and 54.6% in 2009, with wide inter-country variations at each time period. Multiple logistic regression analysis of the whole sample showed that patients taking ACM presented with more severe positive, negative, and extrapyramidal symptoms. They were also more likely to receive first-generation and depot antipsychotics and antipsychotic polypharmacy, and less likely to receive second-generation ones.

Conclusions: The wide variation in ACM prescription across Asia suggests that a combination of clinical, social, economic and cultural factors play a role in determining the use of these drugs. Regular reviews of ACM use are desirable to reveal the discrepancy between treatment guidelines and clinical practice.

语种: 英语
所属项目编号: 30800367 ; 30770776 ; 2008B59 ; 2041454 ; CRC 249/2008 ; DOH92-NH-1025 ; CMRPG83043 ; 97001-62-010
项目资助者: National Science Foundation ; Beijing Municipal Science and Technology Commission in China ; Chinese University of Hong Kong in Hongkong ; Institute of Mental Health Research in Singapore ; Taiwan Bureau of National Health Insurance ; Chang Gung Memorial Hospital ; Taipei City Government in Taiwan
WOS记录号: WOS:000291367000005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53339
Appears in Collections:北京大学精神卫生研究所_期刊论文

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作者单位: 1.CSM Med Univ, Dept Psychiat, Lucknow, Uttar Pradesh, India
2.Natl Seoul Hosp, Seoul, South Korea
3.Songkla Univ, Songkhla, Thailand
4.Univ Geneva, Geneva, Switzerland
5.Seinan Gakuin Univ Fukuoka, Sch Human Sci, Fukuoka, Japan
6.Chinese Univ Hong Kong, Dept Psychiat, Hong Kong, Hong Kong, Peoples R China
7.Capital Med Univ, Beijing Anding Hosp, Beijing, Peoples R China
8.Peking Univ, Inst Mental Hlth, Beijing 100871, Peoples R China
9.Shanghai Mental Hlth Ctr, Shanghai, Peoples R China
10.Univ Notre Dame Australia, Marian Ctr, Perth, WA, Australia
11.Taipei City Hosp, Taipei, Taiwan
12.Chang Gung Univ, Sch Med, Guishan, Taiwan
13.Natl Univ Singapore, Singapore 117548, Singapore
14.HITS, Kobe, Hyogo, Japan
15.Inst Mental Hlth, Buangkok View, Singapore
16.Chang Gung Univ, Kaohsiung Chang Gung Mem Hosp, Guishan, Taiwan
17.Kuala Lumpur Hosp, Dept Psychiat & Mental Hlth, Tunku Abdul Rahman Inst Neurosci, Kuala Lumpur, Malaysia

Recommended Citation:
Xiang, Y. -T.,Wang, C. -Y.,Si, T. -M.,et al. Use of Anticholinergic Drugs in Patients with Schizophrenia in Asia from 2001 to 2009[J]. PHARMACOPSYCHIATRY,2011,44(3):114-118.
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