IR@PKUHSC  > 北京大学精神卫生研究所
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Use of Anticholinergic Drugs in Patients with Schizophrenia in Asia from 2001 to 2009
Xiang, Y. -T.1,2; Wang, C. -Y.2; Si, T. -M.3; Lee, E. H. M.1; He, Y. -L.4; Ungvari, G. S.5; Chiu, H. F. K.1; Yang, S-Y6; Chong, M. -Y.7,8; Tan, C. -H.9; Kua, E. -H.9; Fujii, S.10; Sim, K.11; Yong, K. H.11; Trivedi, J. K.12; Chung, E. -K.13; Udomratn, P.14; Chee, K. -Y.15; Sartorius, N.16; Shinfuku, N.17
刊名PHARMACOPSYCHIATRY
2011-05-01
DOI10.1055/s-0031-1275658
44期:3页:114-118
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pharmacology & Pharmacy ; Psychiatry
研究领域[WOS]Pharmacology & Pharmacy ; Psychiatry
关键词[WOS]CHINESE PATIENTS ; EAST-ASIA ; TARDIVE-DYSKINESIA ; ANTIPSYCHOTIC POLYPHARMACY ; SOCIAL DETERMINANTS ; PRESCRIPTION ; HALOPERIDOL ; MEDICATIONS ; IMPAIRMENT ; WITHDRAWAL
英文摘要

Objective: The aim of this study was to survey the use of anticholinergic medication (ACM) in Asia between 2001 and 2009 and examine its demographic and clinical correlates.

Method: A total of 6761 hospitalized schizophrenia patients in 9 Asian countries and territories were examined between 2001 and 2009. The patients′ socio-demographic and clinical characteristics and the prescriptions of psychotropic drugs were recorded using a standardized protocol and data collection procedure.

Results: The frequency of ACM prescription decreased from 66.3% in 2001, to 52.8% in 2004 and 54.6% in 2009, with wide inter-country variations at each time period. Multiple logistic regression analysis of the whole sample showed that patients taking ACM presented with more severe positive, negative, and extrapyramidal symptoms. They were also more likely to receive first-generation and depot antipsychotics and antipsychotic polypharmacy, and less likely to receive second-generation ones.

Conclusions: The wide variation in ACM prescription across Asia suggests that a combination of clinical, social, economic and cultural factors play a role in determining the use of these drugs. Regular reviews of ACM use are desirable to reveal the discrepancy between treatment guidelines and clinical practice.

语种英语
WOS记录号WOS:000291367000005
项目编号30800367 ; 30770776 ; 2008B59 ; 2041454 ; CRC 249/2008 ; DOH92-NH-1025 ; CMRPG83043 ; 97001-62-010
资助机构National Science Foundation ; Beijing Municipal Science and Technology Commission in China ; Chinese University of Hong Kong in Hongkong ; Institute of Mental Health Research in Singapore ; Taiwan Bureau of National Health Insurance ; Chang Gung Memorial Hospital ; Taipei City Government in Taiwan
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53339
专题北京大学精神卫生研究所
作者单位1.CSM Med Univ, Dept Psychiat, Lucknow, Uttar Pradesh, India
2.Natl Seoul Hosp, Seoul, South Korea
3.Songkla Univ, Songkhla, Thailand
4.Univ Geneva, Geneva, Switzerland
5.Seinan Gakuin Univ Fukuoka, Sch Human Sci, Fukuoka, Japan
6.Chinese Univ Hong Kong, Dept Psychiat, Hong Kong, Hong Kong, Peoples R China
7.Capital Med Univ, Beijing Anding Hosp, Beijing, Peoples R China
8.Peking Univ, Inst Mental Hlth, Beijing 100871, Peoples R China
9.Shanghai Mental Hlth Ctr, Shanghai, Peoples R China
10.Univ Notre Dame Australia, Marian Ctr, Perth, WA, Australia
11.Taipei City Hosp, Taipei, Taiwan
12.Chang Gung Univ, Sch Med, Guishan, Taiwan
13.Natl Univ Singapore, Singapore 117548, Singapore
14.HITS, Kobe, Hyogo, Japan
15.Inst Mental Hlth, Buangkok View, Singapore
16.Chang Gung Univ, Kaohsiung Chang Gung Mem Hosp, Guishan, Taiwan
17.Kuala Lumpur Hosp, Dept Psychiat & Mental Hlth, Tunku Abdul Rahman Inst Neurosci, Kuala Lumpur, Malaysia
推荐引用方式
GB/T 7714
Xiang, Y. -T.,Wang, C. -Y.,Si, T. -M.,et al. Use of Anticholinergic Drugs in Patients with Schizophrenia in Asia from 2001 to 2009[J]. PHARMACOPSYCHIATRY,2011,44(3):114-118.
APA Xiang, Y. -T..,Wang, C. -Y..,Si, T. -M..,Lee, E. H. M..,He, Y. -L..,...&Shinfuku, N..(2011).Use of Anticholinergic Drugs in Patients with Schizophrenia in Asia from 2001 to 2009.PHARMACOPSYCHIATRY,44(3),114-118.
MLA Xiang, Y. -T.,et al."Use of Anticholinergic Drugs in Patients with Schizophrenia in Asia from 2001 to 2009".PHARMACOPSYCHIATRY 44.3(2011):114-118.
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