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学科主题: 基础医学
题名:
Lipid Metabolism and Neuroinflammation in Alzheimer′s Disease: A Role for Liver X Receptors
作者: Kang, Jihong2,3; Rivest, Serge1
刊名: ENDOCRINE REVIEWS
发表日期: 2012-10-01
DOI: 10.1210/er.2011-1049
卷: 33, 期:5, 页:715-746
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Endocrinology & Metabolism
研究领域[WOS]: Endocrinology & Metabolism
关键词[WOS]: CENTRAL-NERVOUS-SYSTEM ; APOLIPOPROTEIN-E-GENE ; DENSITY-LIPOPROTEIN RECEPTOR ; TRANSGENIC MOUSE MODEL ; AMYLOID-BETA-PEPTIDE ; TOLL-LIKE RECEPTORS ; BINDING CASSETTE TRANSPORTERS ; NECROSIS-FACTOR-ALPHA ; E MESSENGER-RNA ; NONSTEROIDAL ANTIINFLAMMATORY DRUGS
英文摘要:

Liver X receptors (LXR) are nuclear receptors that have emerged as key regulators of lipid metabolism. In addition to their functions as cholesterol sensors, LXR have also been found to regulate inflammatory responses in macrophages. Alzheimer′s disease (AD) is a neurodegenerative disease characterized by a progressive cognitive decline associated with inflammation. Evidence indicates that the initiation and progression of AD is linked to aberrant cholesterol metabolism and inflammation. Activation of LXR can regulate neuroinflammation and decrease amyloid-beta peptide accumulation. Here, we highlight the role of LXR in orchestrating lipid homeostasis and neuroinflammation in the brain. In addition, diabetes mellitus is also briefly discussed as a significant risk factor for AD because of the appearing beneficial effects of LXR on glucose homeostasis. The ability of LXR to attenuate AD pathology makes them potential therapeutic targets for this neurodegenerative disease. (Endocrine Reviews 33: 715-746, 2012)

语种: 英语
所属项目编号: 81100398
项目资助者: National Natural Science Foundation of China ; The Canadian Institutes for Health Research
WOS记录号: WOS:000309654300002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53341
Appears in Collections:基础医学院_心血管所_期刊论文

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作者单位: 1.Univ Laval, Ctr Hosp Univ Quebec, Dept Mol Med, Lab Endocrinol & Genom,Ctr Rech, Quebec City, PQ G1V 4G2, Canada
2.Peking Univ, Hlth Sci Ctr, State Educ Minist, Dept Physiol & Pathophysiol, Beijing 100191, Peoples R China
3.Peking Univ, Hlth Sci Ctr, State Educ Minist, Key Lab Mol Cardiovasc Sci, Beijing 100191, Peoples R China

Recommended Citation:
Kang, Jihong,Rivest, Serge. Lipid Metabolism and Neuroinflammation in Alzheimer′s Disease: A Role for Liver X Receptors[J]. ENDOCRINE REVIEWS,2012,33(5):715-746.
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