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学科主题: 基础医学
题名:
The measurement of shear modulus and membrane surface viscosity of RBC membrane with Ektacytometry: A new technique
作者: Lu, Xiao1; Tang, Zhi-yu1; Zeng, Zhu1; Chen, Xi1; Yao, Wei-juan1; Yan, Zong-yi1; Shi, Yan1; Shan, Hui-xian1; Sun, Da-gong1; He, Dong-qi1; Wen, Zong-yao1
关键词: RBC membrane ; shear modulus ; membrane surface viscosity ; ektacytometry ; flow chamber
刊名: MATHEMATICAL BIOSCIENCES
发表日期: 2007-09-01
DOI: 10.1016/j.mbs.2006.09.026
卷: 209, 期:1, 页:190-204
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biology ; Mathematical & Computational Biology
研究领域[WOS]: Life Sciences & Biomedicine - Other Topics ; Mathematical & Computational Biology
关键词[WOS]: RED-BLOOD-CELL ; FLOW FIELD ; HUMAN ERYTHROCYTE ; ORIENTATION ; DEFORMATION ; DEFORMABILITY ; ELASTICITY
英文摘要:

A new technique is proposed to estimate the shear modulus (p) and membrane surface viscosity (eta(m)) of red blood cell (RBC). Theoretical formulae for finding these two parameters are first derived based on the force balance on a RBC in a flow field of low viscosity. Different types of Ektacytometry are then used to measure relevant quantities. The obtained values (mu = 6.1 x 10(-6) N/m, eta(m) = 8.8 X 10(-7) N s/m for normal RBC) are consistent with those previously found by micropipette technique and in AC electric field. The present technique is, however, much easier to operate and more advantageous in reflecting the average properties of a large quantity of RBCs, and it is much cheaper to be applied in clinical practice than any other method of measuring the two parameters. The sensitivity of the technique is demonstrated by

语种: 英语
WOS记录号: WOS:000249511300010
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53342
Appears in Collections:基础医学院_生物物理学系_期刊论文

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作者单位: 1.Chengde Med Coll, Dept Math, Chengde 067000, Peoples R China
2.Beijing Univ, Dept Math, Beijing 100083, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Dept Biophys, Beijing 100083, Peoples R China
4.Peking Univ, Dept Mech & Engn Sci, Beijing 100871, Peoples R China
5.Peking Univ, Hlth Sci Ctr, Dept Appl Sci, Beijing 100083, Peoples R China

Recommended Citation:
Lu, Xiao,Tang, Zhi-yu,Zeng, Zhu,et al. The measurement of shear modulus and membrane surface viscosity of RBC membrane with Ektacytometry: A new technique[J]. MATHEMATICAL BIOSCIENCES,2007,209(1):190-204.
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