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学科主题: 药学
题名:
Studies on the kinetics of cobalt(III) complexes with various charge and chirality crossing human erythrocyte membrane
作者: Wu, G; Li, RC; Qiao, XW; Wang, JC
关键词: cobalt ; human erythrocytes ; kinetics
刊名: CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE
发表日期: 2001-07-01
卷: 22, 期:7, 页:1077-1080
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Multidisciplinary
研究领域[WOS]: Chemistry
关键词[WOS]: CARRIER LIGAND ; TRANSPORT ; SELECTIVITY
英文摘要:

The kinetics that four complexes with various charge and chirality crossed human erythrocyte membrane was studied, and their rate constants(k) of first-order kinetics were determined. The experimental results showed that the [Co(C2O4)(3)](3-) has an obviously higher rate of cross-membrane than [Co(en)(3)](3+), [Co(en)(2)(C2O4)](+) and [Co(en)(C2O4)(2)](-), and the k values of the latter three kinds of complexes increased gradually with the decreasing of their positive charge, their mechanism of transmembrane transport are simple passive diffusion. The rate of transmembrane transport of [Co(C2O4)(3)](3-) was obviously inhibited by DIDS, an anion channel inhibitor, the inhibition rate is 51.95%, its mechanism of transmembrane transport has been considered involving anion channel transport and passive diffusion. The uptake rate of L-[Co(C2O4)(3)](3-) is larger than that of D-[Co(C2O4)(3)](3-) by human erythrocytes, this exhibited that there was chiral selectivity when erythrocytes took up the optical isomers.

语种: 中文
WOS记录号: WOS:000170457300001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53344
Appears in Collections:北京大学药学院_化学生物学系_期刊论文

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作者单位: Beijing Univ, Dept Biol Chem, Sch Pharmaceut Sci, Beijing 100083, Peoples R China

Recommended Citation:
Wu, G,Li, RC,Qiao, XW,et al. Studies on the kinetics of cobalt(III) complexes with various charge and chirality crossing human erythrocyte membrane[J]. CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,2001,22(7):1077-1080.
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