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Studies on the kinetics of cobalt(III) complexes with various charge and chirality crossing human erythrocyte membrane
Wu, G; Li, RC; Qiao, XW; Wang, JC
关键词Cobalt Human Erythrocytes Kinetics
刊名CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE
2001-07-01
22期:7页:1077-1080
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Multidisciplinary
研究领域[WOS]Chemistry
关键词[WOS]CARRIER LIGAND ; TRANSPORT ; SELECTIVITY
英文摘要

The kinetics that four complexes with various charge and chirality crossed human erythrocyte membrane was studied, and their rate constants(k) of first-order kinetics were determined. The experimental results showed that the [Co(C2O4)(3)](3-) has an obviously higher rate of cross-membrane than [Co(en)(3)](3+), [Co(en)(2)(C2O4)](+) and [Co(en)(C2O4)(2)](-), and the k values of the latter three kinds of complexes increased gradually with the decreasing of their positive charge, their mechanism of transmembrane transport are simple passive diffusion. The rate of transmembrane transport of [Co(C2O4)(3)](3-) was obviously inhibited by DIDS, an anion channel inhibitor, the inhibition rate is 51.95%, its mechanism of transmembrane transport has been considered involving anion channel transport and passive diffusion. The uptake rate of L-[Co(C2O4)(3)](3-) is larger than that of D-[Co(C2O4)(3)](3-) by human erythrocytes, this exhibited that there was chiral selectivity when erythrocytes took up the optical isomers.

语种中文
WOS记录号WOS:000170457300001
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53344
专题北京大学药学院_化学生物学系
北京大学第二临床医学院_麻醉科
作者单位Beijing Univ, Dept Biol Chem, Sch Pharmaceut Sci, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Wu, G,Li, RC,Qiao, XW,et al. Studies on the kinetics of cobalt(III) complexes with various charge and chirality crossing human erythrocyte membrane[J]. CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,2001,22(7):1077-1080.
APA Wu, G,Li, RC,Qiao, XW,&Wang, JC.(2001).Studies on the kinetics of cobalt(III) complexes with various charge and chirality crossing human erythrocyte membrane.CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,22(7),1077-1080.
MLA Wu, G,et al."Studies on the kinetics of cobalt(III) complexes with various charge and chirality crossing human erythrocyte membrane".CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE 22.7(2001):1077-1080.
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