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IR@PKUHSC  > 北京大学第三临床医学院  > 生殖医学中心  > 期刊论文
学科主题: 临床医学
题名:
Mesenchymal Stem Cells Enhance Angiogenesis and Follicle Survival in Human Cryopreserved Ovarian Cortex Transplantation
作者: Xia, Xi1,2,3; Yin, Tailang1,4; Yan, Jie1,4; Yan, Liying1,4; Jin, Chao5; Lu, Cuilin1,4; Wang, Tianren1,4; Zhu, Xiaohui1,3,4; Zhi, Xu1,3,4; Wang, Jijun1,4,6; Tian, Lei1,4,6; Liu, Jing5; Li, Rong1,3,4; Qiao, Jie1,3,4
关键词: Ovarian cortex transplantation ; Mesenchymal stem cells (MSCs) ; Fertility preservation ; Ovarian cryopreservation ; Follicle survival
刊名: CELL TRANSPLANTATION
发表日期: 2015
DOI: 10.3727/096368914X685267
卷: 24, 期:10, 页:1999-2010
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cell & Tissue Engineering ; Medicine, Research & Experimental ; Transplantation
研究领域[WOS]: Cell Biology ; Research & Experimental Medicine ; Transplantation
关键词[WOS]: FIBROBLAST-GROWTH-FACTOR ; FERTILITY PRESERVATION ; IN-VIVO ; STROMAL CELLS ; LIVE BIRTH ; TISSUE ; CANCER ; PREGNANCY ; DISEASE ; MICE
英文摘要:

Transplantation of cryopreserved ovarian tissue is a novel technique to restore endocrine function and fertility especially for cancer patients. However, the main obstacle of the technique is massive follicle loss as a result of ischemia in the process of transplantation. Mesenchymal stem cells (MSCs) have been acknowledged to play an important role in supporting angiogenesis and stabilizing long-lasting blood vessel networks through release of angiogenic factors and differentiation into pericytes and endothelial cells. This study is aimed to investigate whether MSCs could be applied to overcome the above obstacle to support the ovarian tissue survival in the transplantation. Here we show that human MSCs could enhance the expression level of VEGF, FGF2, and especially the level of angiogenin, significantly stimulate neovascularization, and increase blood perfusion of the grafts in the cryopreserved ovarian tissue transplantation. Further studies reveal that MSCs could notably reduce the apoptotic rates of primordial follicles and decrease follicle loss in the grafted ovarian tissues. In summary, our findings demonstrate a previously unrecognized function of MSCs in improving human ovarian tissue transplantation and provide a useful strategy to optimize fertility preservation and restoration.

语种: 英语
所属项目编号: 2011CB944500 ; 81471508 ; 31230047 ; 81000275 ; 81101971 ; 81200470 ; 81370759 ; 81070493 ; 81300456 ; 2013M540027 ; A2014665
项目资助者: 973 Program of China ; National Science Foundation ; Postdoctoral Foundation of China ; Guangdong Medical Scientific Foundation
WOS记录号: WOS:000362861200007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53346
Appears in Collections:北京大学第三临床医学院_生殖医学中心_期刊论文

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作者单位: 1.Peking Univ, Hosp 3, Ctr Reprod Med, Dept Obstet & Gynecol, Beijing 100191, Peoples R China
2.Peking Univ, Shenzhen Hosp, Dept Reprod Med, Shenzhen, Peoples R China
3.Minist Educ, Key Lab Assisted Reprod, Beijing, Peoples R China
4.Beijing Key Lab Reprod Endocrinol & Assisted Repr, Beijing, Peoples R China
5.Tsinghua Univ, Sch Med, Dept Biomed Engn, Beijing 100084, Peoples R China
6.Peking Univ, Hosp 3, Dept Hematol, Beijing 100871, Peoples R China

Recommended Citation:
Xia, Xi,Yin, Tailang,Yan, Jie,et al. Mesenchymal Stem Cells Enhance Angiogenesis and Follicle Survival in Human Cryopreserved Ovarian Cortex Transplantation[J]. CELL TRANSPLANTATION,2015,24(10):1999-2010.
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