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Isoflavone intake inhibits the development of 7,12-dimethylbenz(a)anthracene(DMBA)-induced mammary tumors in normal and ovariectomized rats
Ma, Defu1; Zhang, Yumei2; Yang, Titi1; Xue, Yong1; Wang, Peiyu1
关键词Isoflavones Mammary Tumors Ovariectomized Rats Estrogen Receptor
刊名JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION
2014
DOI10.3164/jcbn.13-33
54期:1页:31-38
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Nutrition & Dietetics
研究领域[WOS]Nutrition & Dietetics
关键词[WOS]BREAST-CANCER RISK ; SPRAGUE-DAWLEY RATS ; SOY INTAKE ; PHYTOESTROGENS ; ESTROGEN ; GENISTEIN ; TUMORIGENESIS ; ANTIOXIDANT ; EXPRESSION ; HEALTH
英文摘要

To determine the associations between isoflavone (49.72% genistin, 5.32% daidzin, 34.54% glycitin) and breast cancer risk, 150 rats were given 5 mg 7,12-dimethylbenz(a)anthracene and half of them were ovariectomized. Then normal rats and ovariectomized rats were divided Into 5 groups: control group, isoflavone high (HI), middle (MI), or low (LI) dose group consuming 100, 500, or 1000 mg isoflavones/kg diet, estrogen group (2.5 mg stilboestrol/kg diet). After 24 weeks, tumor incidences were 73% in control group, 7% In HI, 7% In MI, 27% in U. and 80% in estrogen group for normal rats; 60% in control group, 13% in HI, 7% in MI, 13% in U, and 73% in estrogen group for ovariettomized rats. Isoflavone treatment decreased tumor incidence and mean tumor number per rat and increased mean latent period compared with those in control group and estrogen group group significantly (p<0.05). The mRNA and protein expression of estrogen receptor p were significantly higher in isoflavone treatment groups than those in control group group. Moreover, isoflavone treatment significantly decreased 8-hydroxydeoxyguanosine content and Increased superoxide dismutase level in normal rats and decreased malondialdehyde concentrations in ovariectomized rats compared with control group. In conclusions, isoflavone intake significantly inhibited the development of premenopausal and postmenopausal mammary tumors.

语种英语
WOS记录号WOS:000342736600007
项目编号81172653 ; 30872115 ; 30872114 ; 81202193 ; 7122103
资助机构National Natural Science Foundation of China ; Beijing Natural Science Foundation
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53347
专题北京大学公共卫生学院
北京大学药学院_药剂学系
北京大学公共卫生学院_营养与食品卫生学系
北京大学公共卫生学院_公共卫生学院
作者单位1.Peking Univ, Hlth Sci Ctr, Sch Publ Hlth, Dept Social Med & Hlth Educ, Beijing 100191, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Sch Publ Hlth, Dept Nutr & Food Hyg, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Ma, Defu,Zhang, Yumei,Yang, Titi,et al. Isoflavone intake inhibits the development of 7,12-dimethylbenz(a)anthracene(DMBA)-induced mammary tumors in normal and ovariectomized rats[J]. JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION,2014,54(1):31-38.
APA Ma, Defu,Zhang, Yumei,Yang, Titi,Xue, Yong,&Wang, Peiyu.(2014).Isoflavone intake inhibits the development of 7,12-dimethylbenz(a)anthracene(DMBA)-induced mammary tumors in normal and ovariectomized rats.JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION,54(1),31-38.
MLA Ma, Defu,et al."Isoflavone intake inhibits the development of 7,12-dimethylbenz(a)anthracene(DMBA)-induced mammary tumors in normal and ovariectomized rats".JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION 54.1(2014):31-38.
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